Amount of Epithelioid Differentiation Is a Predictor of Survival in Malignant Pleural Mesothelioma

Vigneswaran, Wickii T.; Kircheva, Diana Y.; Ananthanarayanan, Viju; Watson, Sydeaka; Arif, Qudsia; Celauro, Amy D.; Kindler, Hedy L.; Husain, Aliya N.

doi:10.1016/j.athoracsur.2016.08.063

Cited by 45 publications

(36 citation statements)

References 19 publications

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“…Multiple observational studies have reported prognostic factors in mesothelioma, although many were susceptible to selection bias, having been undertaken in selected populations [164][165][166][167][168][169][170][171]. The forthcoming ERS task force statement on mesothelioma contains information on prognostication, and therefore a full summary of the literature is not replicated here.…”

Section: Prognostication In Mesotheliomamentioning

confidence: 99%

“…In brief, certain factors are consistently associated with survival in mesothelioma, i.e. sex, age, epithelioid differentiation, PS and tumour stage [117,157,[164][165][166][167][168][169][170][172][173][174][175][176][177][178][179][180][181]. However, for other factors, including presenting symptoms or quantification of asbestos exposure, the relationship with survival is less clear [163,165,168,173,[182][183][184].…”

Section: Prognostication In Mesotheliomamentioning

confidence: 99%

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ERS/EACTS statement on the management of malignant pleural effusions

et al. 2018

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Malignant pleural effusions (MPE) are a common pathology, treated by respiratory physicians and thoracic surgeons alike. In recent years, several well-designed randomised clinical trials have been published that have changed the landscape of MPE management. The European Respiratory Society (ERS) and the European Association for Cardio-Thoracic Surgery (EACTS) established a multidisciplinary collaboration of clinicians with expertise in the management of MPE with the aim of producing a comprehensive review of the scientific literature.Six areas of interest were identified, including the optimum management of symptomatic MPE, management of trapped lung in MPE, management of loculated MPE, prognostic factors in MPE, whether there is a role for oncological therapies prior to intervention for MPE and whether a histological diagnosis is always required in MPE.The literature revealed that talc pleurodesis and indwelling pleural catheters effectively manage the symptoms of MPE. There was limited evidence regarding the management of trapped lung or loculated MPE. The LENT score was identified as a validated tool for predicting survival in MPE, with Brims' prognostic score demonstrating utility in mesothelioma prognostication. There was no evidence to support the use of oncological therapies as an alternative to MPE drainage, and the literature supported the use of tissue biopsy as the gold standard for diagnosis and treatment planning.

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Section: Prognostication In Mesotheliomamentioning

confidence: 99%

Section: Prognostication In Mesotheliomamentioning

confidence: 99%

ERS/EACTS statement on the management of malignant pleural effusions

et al. 2018

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“…Some data addressing this question has previously been reported in previous studies. For patients undergoing surgery, superior survival has been reported for those with increased epithelioid component (12).…”

Section: The Who Classification Of Biphasic Mesothelioma Includes Allmentioning

confidence: 99%

Differential Survival Characteristics of Sarcomatoid Subtype in Biphasic Pleural Mesothelioma

Harling

Kolokotroni

Nair

et al. 2019

The Annals of Thoracic Surgery

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“…Recently, the clinical and prognostic significance of many of these patterns has been demonstrated (35)(36)(37). Moreover, Kadota and collaborators proposed a nuclear grading system for epithelioid MPM with a prognostic value independent from histologic patterns (38).…”

Section: Histologic Patterns Of Mpmmentioning

confidence: 99%

The pathological and molecular diagnosis of malignant pleural mesothelioma: a literature review

Alì¹,

Bruno²,

Fontanini³

2018

J. Thorac. Dis.

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on the application of a panel including positive (mesothelial-related) and negative markers with greater than 80% sensitivity and specificity, which need to be selected based on morphology and clinical information.Moreover, in challenging cases, fluorescent in situ hybridization (FISH) testing for the p16 deletion and IHC to evaluate the loss of BRCA1-associated protein 1 (BAP1) expression could be useful in distinguishing benign from malignant pleural proliferations.

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Amount of Epithelioid Differentiation Is a Predictor of Survival in Malignant Pleural Mesothelioma

Abstract: The percentage of epithelioid differentiation is an independent predictor of survival in MPM and should be taken into careful consideration when recommending surgical treatment for patients with biphasic MPM.

Cited by 45 publications

References 19 publications

ERS/EACTS statement on the management of malignant pleural effusions

ERS/EACTS statement on the management of malignant pleural effusions

Differential Survival Characteristics of Sarcomatoid Subtype in Biphasic Pleural Mesothelioma

The pathological and molecular diagnosis of malignant pleural mesothelioma: a literature review

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