Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial

Griffiths, Gareth; Ayob, Rasidah; Guerrero, Adrián; Nibali, Luigi; Suvan, Jean; Moles, David R; Tonetti, Maurizio S.

doi:10.1111/j.1600-051x.2010.01632.x

Cited by 95 publications

(138 citation statements)

References 23 publications

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“…A systematic review in 2008 trying to assess the relative benefit of prescribing antibiotics either during the non-surgical or the surgical phase of therapy remained inconclusive [60]. However, two studies, not included in this review, showed better clinical outcomes for subjects with generalized aggressive periodontitis if patients were given amoxicillin and metronidazole immediately after initial scaling and root planing rather than after re-treatment of persisting pathology [61,62]. In 51 patients diagnosed with chronic periodontitis, systemic metronidazole and amoxicillin significantly improved the 6-month clinical outcomes of extensive fullmouth non-surgical periodontal debridement provided in 48 h, thereby significantly reducing the need for additional therapy [49,63].…”

Section: Which Is the Optimal Time Point For Administering Antibiotics?mentioning

confidence: 97%

Antimicrobial Advances in Treating Periodontal Diseases

Mombelli¹

2011

Frontiers of Oral Biology

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Antibiotics are generally an efficient means of treating bacterial infections, and therefore are an obvious candidate in the treatment of periodontal diseases. Systemically and locally administered antimicrobial agents of all kinds have been evaluated in multiple clinical trials. The vast majority of studies have tested antibiotics as adjuncts to non-surgical debridement. No regime has demonstrated superiority over systemically administered amoxicillin and metronidazole in the treatment of any clinically or microbiologically defined variant of periodontal disease. The frequency and consequences of adverse effects of antibiotics have always to be balanced against the potential consequences of not rapidly suppressing a periodontal infection. Proposed strategies to reduce the risk of bacterial antimicrobial resistance include: prescribing two drugs with a synergistic or complementary effect, the administration of antibiotics at a high dose for a short period, a combined approach with mechanical debridement to disrupt biofilms, and the focus on therapeutic rather than prophylactic use. Derivatives of existing antibiotic classes and new compounds that act on unique targets are the subject of preclinical investigations with a focus on action against antibiotic-resistant medical pathogens. In light of the excellent results of a combination therapy with well-established drugs that are cheap and efficient, clinical trials should compare newly proposed protocols for periodontal therapy to a positive control. Future studies should focus not only on the action against the microorganisms directly involved in periodontal diseases, but also on those relevant to other medical concerns.

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Section: Which Is the Optimal Time Point For Administering Antibiotics?mentioning

confidence: 97%

Antimicrobial Advances in Treating Periodontal Diseases

Mombelli¹

2011

Frontiers of Oral Biology

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“…[7] The combined use of amoxicillin (AMX) and metronidazole (MTZ) has been proposed to exhibit increased bactericidal, and spectral efficacy compared with monotherapy with either drug. [8,9] The combination of MTZ and AMX in the treatment of aggressive periodontitis has gained recognition mostly due to its effectiveness against Aggregatibacter actinomycetemcomitans, a periodontal pathogen closely associated with the etiology of this infection. [10,11] In addition to A. actinomycetemcomitans, this combination is active against Treponema denticola, Tannerella forsythia, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia.…”

Section: Introductionmentioning

confidence: 99%

Effects of azithromycin versus metronidazole-amoxicillin combination as an adjunct to nonsurgical periodontal therapy of generalized aggressive periodontitis

2015

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“…The preferred combination antibiotic therapy at present for treatment of generalized aggressive periodontitis is 250 mg of amoxicillin thrice daily alone with metronidazole 250 mg twice daily for 8 days 58,62 . It is one of the most evaluated drug combinations in generalized aggressive periodontitis that significantly improves the result and should be preferred over the antibiotic regimens as the first line treatment [63][64][65][66][67][68] . Antibiotics that are bacteriostatic (e.g.…”

Section: Serial and Combination Therapymentioning

confidence: 99%

Management of Rapidly Progressing Periodontitis: An Overview

Sadat¹,

Chowdhury

Baten³

2017

Med. Today

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History of periodontal diseases recognition and treatment is ancient for at least 5000 years. There are different presentations of periodontal diseases. Rapidly progression periodontitis or aggressive periodontitis causes rapid destruction of the periodontium which leads to early tooth loss. It may be generalized or localized. Periodontitis may be treated surgically or non-surgically but patients with rapidly progressing periodontitis do not respond predictably to conventional therapy due to its multi factorial etiology. Successful management of the disease is difficult if not diagnosed early and treated appropriately. Regenerative therapy, tissue engineering and genetic technologies are the new hope for the treatment of rapidly progressing periodontitis.Medicine Today 2016 Vol.28(1): 32-38

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Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial

Abstract: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re-treatment.

Cited by 95 publications

References 23 publications

Antimicrobial Advances in Treating Periodontal Diseases

Antimicrobial Advances in Treating Periodontal Diseases

Effects of azithromycin versus metronidazole-amoxicillin combination as an adjunct to nonsurgical periodontal therapy of generalized aggressive periodontitis

Management of Rapidly Progressing Periodontitis: An Overview

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