Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

Fahmy, Maha A.; Farghaly, Ayman A.; Omara, Enayat A.; Hassan, Zeinab M.; Aly, Fawzia A. E.; Donya, Souria M.; Ibrahim, Aziza A. E.; Bayoumy, Elsayed M.

doi:10.1016/j.apjtb.2017.08.002

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Experimental study of Fahmy et al. (2017) revealed that a 2‐week treatment with amoxicillin‐clavulanic acid at human equivalent dose led to abnormal sperm morphology. Histological examination of cut sections of the testes also revealed decline in the number of spermatozoa, pyknotic cells and congestion of blood vessels.…”

Section: Drug Abusementioning

confidence: 99%

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ajayi

Akhigbe

2020

Andrologia

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Infertility is the failure of a couple to achieve conception after 12 months of adequate unprotected sexual intercourse (Wiwanitkit, 2008). It is a major health challenge with social implications among couples, particularly in the tropics (Yeşilli et al., 2005). Although Mascarenhas, Cheung, Mathers, and Stevens (2012) suggested a dearth of data on the global prevalence of infertility, Boivin, Bunting, Collins, and Nygren (2007) documented that about 72.4 million couples experience fertility problems globally. This accounts for about 15% of couples (Dissanayake, Keerthirathna, & Peiris, 2019). Contrary to the popular misconception that infertility is attributable to female factor, it has been established that about 30%-50% cases of primary infertility is due to male factor (Ajayi &

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Section: Drug Abusementioning

confidence: 99%

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ajayi

Akhigbe

2020

Andrologia

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“…In our study, falling off time was decreased in test rats than control similar to other studies. 12 The β-lactam ring structure shares structural similarities with GABA. AMX interferes with GABA action and reduces GABA mediated inhibition of inward chloride current.…”

Section: Histopathological Changesmentioning

confidence: 99%

“…On administration of the drug for 10 to 14 days in high dose, these adverse effects are more prominent. 12 This study evaluates the neurotoxic adverse effects of amoxicillin like epilepsy and depression in albino rats. The histopathological changes in the organs after the administration of the drug were studied.…”

Section: Introductionmentioning

confidence: 99%

Amoxicillin Induced Behavioral Neurotoxicity and Histopathological Changes in Organs of Albino Rats

Paudel¹,

Aryal

Ranabhat³

2020

J Coll Med Sci-Nepal

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Background: There are various adverse drug reactions of penicillin. Neurotoxicity is attracting the attention of researchers all over the world. It also affects other organs like liver, kidney, heart and testes Methods: The study was conducted at pharmacy and pharmacology department of Gandaki Medical College (GMC) from January till April, 2018. Albino rats were divided six each in test and control group. Tests were administered amoxicillin 90mg/kg/d and control with distilled water for 10 days. After 10 days, rats were tested for neurotoxicity with rota-rod (RR) and modified forced swim test (MFST). They were then sacrificed under anesthesia, organs were dissected and sent for histopathological investigation. Results: The latency to fall from RR apparatus decreased significantly in test rats than control. (P value = 0.0001) In MFST, immobility time was significantly increased than control (P value = 0.0001). Swimming time(ST) was significantly decreased (P value = 0.001) and climbing time (CT) was not significantly altered in test rats than control (P value = 0.352). The liver enzyme, AST and ALT were significantly increased in the test rats (TR) as compared to controls. (P value 0.049 and 0.001 respectively) Brain of test rats (TR) showed shrunken neurons surrounded by perineuronal vacuolations, liver and kidney showed degenerative changes. Vacuolations and pyknotic cells were seen in spermatogonic cells. Conclusions: Neurotoxic effects were seen in test rats which recommends regulation of the administration of high dose of penicillin.

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“…The advantages of supplementing antibiotics to semen extenders as well as preparation, cryopreservation and IVF media have been questioned for a couple of years now. Despite the ability of antibiotics to prevent bacteriospermia, an increased number of reports have emerged emphasizing on the potentially toxic effects of traditional antibiotics on the sperm and embryo vitality [ 8 , 9 , 10 ]. These findings, coupled with a dramatically increasing bacterial resistance to antibiotics, have contributed to the need for finding appropriate alternatives to reduce their widespread use during semen handling.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa

Tvrdá

Lovíšek

Kyzek

et al. 2021

IJMS

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Significant antibacterial properties of non-thermal plasma (NTP) have converted this technology into a promising alternative to the widespread use of antibiotics in assisted reproduction. As substantial data available on the specific in vitro effects of NTP on male reproductive cells are currently missing, this study was designed to investigate selected quality parameters of human spermatozoa (n = 51) exposed to diffuse coplanar surface barrier discharge NTP for 0 s, 15 s, 30 s, 60 s and 90 s. Sperm motility characteristics, membrane integrity, mitochondrial activity, production of reactive oxygen species (ROS), DNA fragmentation and lipid peroxidation (LPO) were investigated immediately following exposure to NTP and 2 h post-NTP treatment. Exposure to NTP with a power input of 40 W for 15 s or 30 s was found to have no negative effects on the sperm structure or function. However, a prolonged NTP treatment impaired all the sperm quality markers in a time- and dose-dependent manner. The most likely mechanism of action of high NTP doses may be connected to ROS overproduction, leading to plasma membrane destabilization, LPO, mitochondrial failure and a subsequent loss of motility as well as DNA integrity. As such, our findings indicate that appropriate plasma exposure conditions need to be carefully selected in order to preserve the sperm vitality, should NTP be used in the practical management of bacteriospermia in the future.

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Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

Cited by 6 publications

References 28 publications

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Amoxicillin Induced Behavioral Neurotoxicity and Histopathological Changes in Organs of Albino Rats

The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa

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