Amoxicillin/Clavulanic Acid-Induced Symmetric Drug-Related Intertrigious and Flexural Exanthema

Abstract

β-Lactams, particularly penicillins, may cause several allergic reactions. We described symmetric drugrelated intertriginous and flexural exanthema (SDRIFE) illness in this case, a rare instance of systemic contact dermatitis caused by amoxicillin/clavulanic acid that needs to be considered in the differential diagnosis. A 65-year-old male patient was admitted to our Allergy Outpatient Clinic because of increased blue-purple pigmentation on the flexural surfaces of the hip, forearm, axilla, and posterior face of the neck. The patient was receiving a combination of angiotensin receptor blocker (ARB) and hydrochlorothiazide diuretic medication for hypertension. The patient used an antibiotic containing amoxicillin three months ago; As a result, there was localized redness, itching, and black spotting without any systemic symptoms. Similarly, the patient reported that when he used amoxicillin for an upper respiratory tract infection eight months ago, he experienced similar side effects within 20 days and recovered when he applied corticosteroid ointment.Due to the symmetrical site involvement following the consumption of penicillin group antibiotics with a five-month gap and subsequent comparable reactions in our patient, SDRIFE was taken into consideration. The results of the skin punch biopsy identified Baboon Syndrome (SDRIFE). Treatment with topical corticosteroids and antihistamines began. Clinically speaking, SDRIFE is distinguished by significant erythema of the gluteal/perianal area and/or V-shaped erythema of the inguinal/perigenital area, symmetric involvement of at least one other intertriginous or flexural area, and the absence of systemic signs or symptoms. The possibility that the medication may have contributed to the patient's erythematous eruption in the flexural regions should be taken into account, and the patient should be advised to stop taking the medication and not use it again.

Symmetrical cutaneous rash in two women

“…Doxorubicin and other anthracyclines are used to treat different hematologic malignancies and solid tumors, with relatively frequent reactions on the skin and the mucosae, including alopecia, mucosal ulcers, papular, and macular eruptions 9 . To our knowledge, this is the first reported case of SDRIFE during doxorubicin chemotherapy, while amoxicillin has been previously associated with SDRIFE and other cutaneous eruptions 8 …”

“…9 To our knowledge, this is the first reported case of SDRIFE during doxorubicin chemotherapy, while amoxicillin has been previously associated with SDRIFE and other cutaneous eruptions. 8 The diagnosis of SDRIFE is based solely on clinical findings, and histological confirmation is not mandatory.…”

“…However, more recent cases, including our two patients, suggest SDRIFE can occur without prior contact allergen sensitization, associated with systemic drug administration 5 . Several authors reported common causative drugs include certain antibiotics (e.g., beta‐lactams, sulphonamides, and macrolides), anticonvulsants (e.g., carbamazepine and phenytoin), and non‐steroidal anti‐inflammatory drugs 5,7,8 . Doxorubicin and other anthracyclines are used to treat different hematologic malignancies and solid tumors, with relatively frequent reactions on the skin and the mucosae, including alopecia, mucosal ulcers, papular, and macular eruptions 9 .…”

“…5 Several authors reported common causative drugs include certain antibiotics (e.g., beta‐lactams, sulphonamides, and macrolides), anticonvulsants (e.g., carbamazepine and phenytoin), and non‐steroidal anti‐inflammatory drugs. 5 , 7 , 8 Doxorubicin and other anthracyclines are used to treat different hematologic malignancies and solid tumors, with relatively frequent reactions on the skin and the mucosae, including alopecia, mucosal ulcers, papular, and macular eruptions. 9 To our knowledge, this is the first reported case of SDRIFE during doxorubicin chemotherapy, while amoxicillin has been previously associated with SDRIFE and other cutaneous eruptions.…”

“… 9 To our knowledge, this is the first reported case of SDRIFE during doxorubicin chemotherapy, while amoxicillin has been previously associated with SDRIFE and other cutaneous eruptions. 8 …”