Amoxicillin induced toxic epidermal necrolysis: a case report

Zachariah, Tittu George; Rao, Kavyarashmi; Noronha, Tonita Mariola; Acharya, Swathi; Pooja, M; J, Noble

doi:10.18203/2319-2003.ijbcp20161582

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Although TEN was rare with severe form of erythema it was important to recognize the clinical characteristics of eruptions at an early stage due to high mortality rate which ranges from 16-25%. 3 In this case report TEN was observed after the initiation of amoxicillin treatment. Then after the withdrawal of amoxicillin TEN symptoms were slowly normalised and improved Patient condition.…”

Section: Discussionmentioning

confidence: 73%

Amoxicillin induced toxic epidermal necrolysis

Narasimha¹,

Kalpana²

2020

Int J Basic Clin Pharmacol

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Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse drug reaction associated with mucocutaneous eruptions and peeling of skin (sloughing) mostly caused by drugs like sulphonamides, beta lactams, carbamazepine and non-steroidal anti-inflammatory drugs (NSAIDs). Amoxicillin is a broad spectrum, bactericidal, Beta-lactam antibiotic used in treatment of various infections. Here by we have reported the case of amoxicillin induced severe toxic epidermal necrolysis. A Patient admitted in the hospital with the symptoms of epidermal sloughing that resulted in bare dermis as he received Amoxicillin drug for his diagnosis of fever. After clear examination TEN was confirmed and suspected with the cause due to Amoxicillin. The drug was stopped and patient was treated with other drugs for symptomatic cure. The patient was recovered from his condition and improved significantly.

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Section: Discussionmentioning

confidence: 73%

Amoxicillin induced toxic epidermal necrolysis

Narasimha¹,

Kalpana²

2020

Int J Basic Clin Pharmacol

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“…Other techniques includes plasmapheresis and haemodialysis that aim to eradicate the causative agent, its metabolites andproinflammatory cytokines from the circulation in an effort to terminate progression of the disease. [7,8] Zacharia T G et al reported TEN following Amoxicillin in a 12 year old male successfullytreated with antibiotics, immunosuppressant and other supportive measures [10] . Patel JB et al describe a case of TEN rigorously managed with systemic corticosteroid and IVIG reporting improvement [8] .…”

Section: Discussion:-mentioning

confidence: 99%

A Case Report on Amoxicillin Induced Toxic Epidermal Necrolysis

Reddy¹,

India²,

Padmini³

et al. 2020

IJAR

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Toxic Epidermal Necrolysis, Amoxicillin, Adverse Drug Reactions Adverse drug reactions are unintended hazardous effects of drug that can occur with any class of medication;however studies have shown a high incidence with antibiotics. Amoxicillin is a broad spectrum beta lactam antibiotic, commonly used in treating infections, is known to cause cutaneous skin eruptions. Toxic epidermal necrolysis (TEN) is a rare but severe life threatening dermatological reaction most often triggered by medications. Here we describe a case of TEN in a 69 year old male following Amoxicillin therapy presenting with mucocutaneous lesions with super added multidrug resistant bacterial infection requiring 20 days of rigorous hospital care.

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Amoxicillin induced toxic epidermal necrolysis: a case report

Cited by 2 publications

References 16 publications

Amoxicillin induced toxic epidermal necrolysis

Amoxicillin induced toxic epidermal necrolysis

A Case Report on Amoxicillin Induced Toxic Epidermal Necrolysis

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