Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influence of PEG coating on the particle size, drug release rate and phagocytic uptake

Fontana, Giacomo; Licciardi, Mariano; Mansueto, Silvana; Schillaci, Domenico; Giammona, Gaetano

doi:10.1016/s0142-9612(01)00030-8

Cited by 186 publications

(91 citation statements)

References 22 publications

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“…The FTIR spectra of PLA homopolymers, shown in Figure 4, present the characteristic absorption bands of this polymer [51] groups, stretching bands at 875 and 789 cm -1 related to C-C groups and a stretching band at 704 cm -1 of the O-H group; these are all in agreement with those reported in the literature [10,52]. In turn, the synthesized PLA were characterized by 1 H-NMR and 13 C-NMR, shown in Figures 5 and 6, respectively. Figure 4 shows the 1 H-NMR spectra of the PLA homopolymers.…”

Section: Synthesis Of Plasupporting

confidence: 85%

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PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

Icart¹,

Santos²,

Pereira³

et al. 2016

Express Polym. Lett.

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Section: Synthesis Of Plasupporting

confidence: 85%

“…most important feature of PEG is its potential for biomasking [11][12][13]. The conjugation of PEG to DDS or drugs (e.g.…”

mentioning

confidence: 99%

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

Icart¹,

Santos²,

Pereira³

et al. 2016

Express Polym. Lett.

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“…First, the mucoadhesive polymer could interact with piperine by hydrogen bonding and is localized at the particle surface thereby being responsible for the initial burst release. Second, the water-soluble property of these polymers might further help the piperine leach out from the particle surface to the dissolution medium [22,23]. The initial burst release of PRE loaded NLCs could be considered as an advantage to provide a sufficient therapeutic dose for inhibiting bacterial growth in a timely manner.…”

Section: Discussionmentioning

confidence: 99%

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Srichaivatana

Ounaroon

Tiyaboonchai

2017

Int J Pharm Pharm Sci

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Objective: To develop and characterize Piper retrofractum extract loaded nanostructured lipid carriers (PRE loaded NLCs) for topical oral cavity administration to enhance bioavailability and stability of piperine.Methods: PRE loaded NLCs were prepared with a hot high-pressure homogenization technique followed by coating the particle surface with mucoadhesive polymers; polyethene glycol 400 (PEG) and polyvinyl alcohol (PVA). The physicochemical properties in terms of particle size, polydispersity index, zeta potential, drug entrapment efficiency, in vitro drug release profile and antimicrobial activities were examined. In vitro, mucoadhesion studies were assessed by the wash-off test. The physicochemical stabilities of mouth spray containing PRE loaded NLCs were investigated by kept at room temperature and 4 °C for 6 mo. Results:The PRE loaded NLCs showed spherical shape with a mean particle size of ~100-120 nm and zeta potential of ~-24 mV. Up to 90% drug entrapment efficiency was achieved. PEG-NLCs and PVA-NLCs showed a strong interaction with porcine buccal mucosa than uncoated-NLCs. All PRE loaded NLCs formulations revealed fast release characteristics and effective against Streptococcus mutans and S. sanguinis. The mouth spray containing PRE loaded NLCs showed good physical stability without particle aggregation. In addition, the chemical stability of piperine in NLCs was significantly improved during storage at both storage conditions compared to its solution form. Conclusion:The developed PRE loaded polymer coated-NLCs showed high potential to use as a local drug delivery system for reducing the bacterial growth in the oral cavity.

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“…Nanostructures were 80 and 230 nm in diameter, by DLS. 22 Moreover, Fontana et al 39 presented an interesting study using amoxicillinloaded polyethylcyanoacrylate nanoparticles with added polyethyleneglycol (PEG), measuring 220-320 nm. Turos et al 14 proposed penicillin-bonded polyacrylate nanoparticles with 25-40 nm.…”

Section: Morphological Characterization Of Nanoparticlesmentioning

confidence: 99%

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Saúde¹,

Ombredane²,

Silva³

et al. 2014

IJN

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Controlling human pathogenic bacteria is a worldwide problem due to increasing bacterial resistance. This has prompted a number of studies investigating peptides isolated from marine animals as a possible alternative for control of human pathogen infections. Clavanins are antimicrobial peptides isolated from the marine tunicate Styela clava , showing 23 amino acid residues in length, cationic properties, and also high bactericidal activity. In spite of clear benefits from the use of peptides, currently 95% of peptide properties have limited pharmaceutical applicability, such as low solubility and short half-life in the circulatory system. Here, nanobiotechnology was used to encapsulate clavanin A in order to develop nanoantibiotics against bacterial sepsis. Clavanin was nanostructured using EUDRAGIT ® L 100-55 and RS 30 D solution (3:1 w:w). Atomic force, scanning electron microscopy and dynamic light scattering showed nanoparticles ranging from 120 to 372 nm in diameter, with a zeta potential of -7.16 mV and a polydispersity index of 0.123. Encapsulation rate of 98% was assessed by reversed-phase chromatography. In vitro bioassays showed that the nanostructured clavanin was partially able to control development of Staphylococcus aureus , Klebsiella pneumoniae , and Pseudomonas aeruginosa . Furthermore, nanostructures did not show hemolytic activity. In vivo sepsis bioassays were performed using C57BL6 mice strain inoculated with a polymicrobial suspension. Assays led to 100% survival rate under sub-lethal sepsis assays and 40% under lethal sepsis assays in the presence of nanoformulated clavanin A until the seventh day of the experiment. Data here reported indicated that nanostructured clavanin A form shows improved antimicrobial activity and has the potential to be used to treat polymicrobial infections.

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Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influence of PEG coating on the particle size, drug release rate and phagocytic uptake

Cited by 186 publications

References 22 publications

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

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