AMOXYCILLIN PLUS TINIDAZOLE FOR CAMPYLOBACTER PYLORI GASTRITIS IN CHILDREN: ASSESSMENT BY SERUM IgG ANTIBODY, PEPSINOGEN I, AND GASTRIN LEVELS

Oderda, Giuseppina; Holton, John; Altare, Frédéric; Vaira, Dino; Ainley, Colin; Ansaldi, N

doi:10.1016/s0140-6736(89)92206-x

Cited by 148 publications

(58 citation statements)

References 10 publications

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“…There were no significant differences in the success rates between patients with nodular antral gastritis and those with nonnodular gastritis or duodenitis (10/11, 90.9% in both groups) or between Israeli-born patients and those born in the former Soviet Union (14/15, 93.3% and 10/12, 83.3%, respectively; P ϭ not significant). Patient compliance, which was assessed by using a direct questionnaire 8.6%), and headache (1 patient, 2.9%). No major adverse effects requiring discontinuation of the study were recorded in any of the study patients.…”

Section: Resultsmentioning

confidence: 99%

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

Moshkowitz¹,

Reif

Brill³

et al. 1998

Pediatrics

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ABSTRACT. Background. Resolution of Helicobacter pylori infection is important in the management of peptic ulcer disease and reduces peptic ulcer recurrence in both adults and children. Various anti-H pylori treatment regimens have been proposed, reflecting the incomplete clinical success of each. A combination of omeprazole, clarithromycin, and tinidazole, given for 1 week, has been shown to be highly tolerable and effective, achieving a success rate of >90% in the adult population.Objective. The aim of this study was to evaluate this short-term regimen in pediatric and adolescent populations.Methods. The study group consisted of 35 children referred for evaluation of dyspeptic symptoms. They all underwent upper gastrointestinal endoscopy, in which H pylori infection was confirmed by rapid urease test and/or histologic staining. They were given omeprazole (20 mg twice daily), clarithromycin (250 mg twice daily), and tinidazole or metronidazole (500 mg twice daily) for 1 week. The patients were divided into two groups: those who received the first course of anti-H pylori therapy during this study (group 1) and those who had previously received standard metronidazole and bismuth combination therapies that failed to eradicate H pylori (group 2). Therapeutic efficacy was assessed by a 13 C-urea breath test performed 4 weeks after completion of treatment.Results. The 35 study patients had a mean age of 15.9 years (range, 10 to 19) and included 19 males and 16 females, of whom 22 were born in Israel and 13 were immigrants from the former USSR. There were 27 patients (77.1%) in group 1 and 8 patients (22.9%) in group 2. Endoscopic findings were nodular gastritis (14), gastritis (11), gastric ulcer (1), duodenal ulcer (5), and duodenitis (4). H pylori resolution was significantly higher in group 1 patients (24/27, 88.9%) than in group 2 patients (1/8, 12.5%). There was no difference between patients with nodular gastritis and those with nonnodular gastritis, and between Israeli-born patients and patients born in the former USSR. Compliance in both groups was equally good, and no major side effects were recorded.Conclusions. One-week omeprazole/clarithromycin/ tinidazole triple therapy is highly tolerable and effective for treating H pylori in the pediatric age group, but previous treatment failure diminishes the likelihood of success with this regimen. Pediatrics 1998;102(1). URL: http://www.pediatrics.org/cgi/content/full/102/1/e14; Helicobacter pylori, triple therapy, children, adolescents, omeprazole, clarithromycin.

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Section: Resultsmentioning

confidence: 99%

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

Moshkowitz¹,

Reif

Brill³

et al. 1998

Pediatrics

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“…29) Eradication of Hp resulted in a relative decrease in anti-Hp titers and serum gastrin concentrations in this study, in line with previous studies in humans showing that Hp resulted in a decrease in serum gastrin concentrations. 30,31) Earlier eradication of Hp was demonstrated to be effective in preventing gastric carcinogenesis in an in vivo experimental carcinogenesis model. Lasting chronic active inflammation with the infection of Hp, formation of gastric cell proliferation and enhancement of gastric cancers and biological mediators might have roles in gastric carcinogenesis, in addition to the direct action of various virulence factors of Hp.…”

Section: Discussionmentioning

confidence: 99%

Effect of early eradication on Helicobacter pylori‐related gastric carcinogenesis in Mongolian gerbils

et al. 2003

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“…To grade the degree of severity of antral inflammatory cells, Marshall's criteria were adopted.9 We also quantified the numbers of mononuclear and polymorphonuclear cells infiltrating surface and glandular epi- Inflammatory cells were counted by two observers (DDO and MF) who were unaware of the patient data, using the same microscope at an enlargement of 400 times on at least 10 fields on four to six haematoxylin and eosin stained sections 5 …”

Section: Methodsmentioning

confidence: 99%

Serum pepsinogen I and gastrin concentrations in children positive for Helicobacter pylori.

et al. 1990

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Similarly, the total inflammatory score and serum pepsinogen concentrations were significantly correlated. There was no such correlation in children negative for H pylori. After treatment the inflammatory score improved in those patients in whom H pylori had been eradicated. There was also a significant fall in serum pepsinogen I and serum gastrin concentration in those patients in whom H pylori had been eradicated. These results were similar to those found six months after treatment had been stopped.These findings suggest that the serum pepsinogen I concentration could be considered a useful marker for gastritis and can be used as an index of severity of gastritis in H pylori positive subjects. The measurement of serum gastrin concentrations does not give useful information.In adults a strong association is now recognised between the presence of Helicobacter pylori in gastric mucosa and histologically confirmed gastritis.' H pylori has also been specifically associated with primary antral gastritis in children, and as in adults the organism is present only in the gastric mucosa with concomitant gastric inflammation.23 Raised serum pepsinogen I concentrations are found in about two thirds of adults with peptic ulcer disease,4 and are thought to be a useful subclinical marker of genetic predisposition to ulceration. Serum pepsinogen I concentrations and a high titre of antibody to H pylori have been found to be raised in children with H pylori associated gastritis.2 Moreover, it has been shown that the concentrations of serum pepsinogen I, gastrin, and IgG antibody to H pylori significantly decreased after a six week course of amoxycillin and tinidazole.'

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AMOXYCILLIN PLUS TINIDAZOLE FOR CAMPYLOBACTER PYLORI GASTRITIS IN CHILDREN: ASSESSMENT BY SERUM IgG ANTIBODY, PEPSINOGEN I, AND GASTRIN LEVELS

Cited by 148 publications

References 10 publications

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

Effect of early eradication on Helicobacter pylori‐related gastric carcinogenesis in Mongolian gerbils

Serum pepsinogen I and gastrin concentrations in children positive for Helicobacter pylori.

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