α₂HS-Glycoprotein Phenotype and Allele Distribution in Continental Italy and Sardinia

Abstract

The genetic polymorphism of α₂HS-glycoprotein (A2HS) was studied in continental Italy (Rome and L’Aquila) and in Sardinia (Cagliari). The two continental populations did not differ significantly in the A2HS gene distribution, whereas the Sardinian population showed an A2HS*1 frequency significantly higher than in continental Italy.

Genetic Polymorphism of Alpha-2-HS-Glycoprotein in a Spanish Population

“…The numbers observed were in agreement with those expected calculated on the basis of the Hardy-Weinberg equi librium. The AllSG* 1 and AHSG*2 allele frequencies observed in Spain are very similar to those previously reported in France 113) and continental Italy [14], while they show an insignificant difference but somewhat higher AHSG*1 and lower A11SG*2 frequencies when compared with the AHSG population data from Norway [15], England [16] and Germany [17]. Therefore, the Spanish population data arc also in agreement with the suggested north-to-south AHSG gcnocline [II].…”

Alpha-2-HS-Glycoprotein Phenotype Frequencies in Cook Islanders

“…Furthermore the Rarotongan population has a higher degree of admix ture with non-Polynesians (13%) than the Mangaian one (5%). The European popu lations have A2HS*2 frequencies in a range of 0.36-0.21 [5,6,10,11], Thomas [7] reported the A2HS*1 frequency to be 0.358 in Brisbane, Australia. It is sug gested, therefore, that admixture with Eu ropean or Australian immigrants may be the reason for the somewhat lower A2HS*2 frequency in the Rarotongans.…”

Distribution of ORM1, C6, C7 and APO C-ll Allele Frequencies in Populations from Mainland Italy and Sardinia

“…We have considered the two populations separately because, in addition to the welldocumented high frequency of thalassemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency [211, they have been shown to differ for gene frequencies in many genetic systems [22][23][24][25].…”