2017
DOI: 10.2147/dddt.s130088
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&beta;<sub>3</sub>-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells

Abstract: ObjectiveThe aim of this study was to explore the effects of β3-adrenoceptor (β3-AR) activation on HepG2 cells and its influence on cholesterol efflux from macrophage foam cells.Materials and methodsHepG2 cells were cultured and treated with the β3-AR agonist, BRL37344, and antagonist, SR52390A, and the expression of apolipoprotein (Apo) A-I, ApoA-II, ApoB, and β3-AR in the supernatants and cells was determined. The expression of peroxisome proliferator-activated receptor (PPAR) γ and PPARα in the HepG2 cells … Show more

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Cited by 4 publications
(2 citation statements)
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“…However, treatment with linoleic acid and fenofibrate in the non-hypercholesterolemic rats did not show any significant difference compared with the control non-hypercholesterolemic rats. Evidence shows that the activation of the PPARα pathway in the liver is responsible for the lipid-lowering action [ 62 ]. PPARα is a ligand-activated transcription factor that controls a comprehensive set of genes involved in most aspects of lipid catabolism.…”
Section: Discussionmentioning
confidence: 99%
“…However, treatment with linoleic acid and fenofibrate in the non-hypercholesterolemic rats did not show any significant difference compared with the control non-hypercholesterolemic rats. Evidence shows that the activation of the PPARα pathway in the liver is responsible for the lipid-lowering action [ 62 ]. PPARα is a ligand-activated transcription factor that controls a comprehensive set of genes involved in most aspects of lipid catabolism.…”
Section: Discussionmentioning
confidence: 99%
“…It might be involved in lipid raft associated neuron function and inflammatory response in IRI ( Paciullo et al, 2017 ). Adrb3 encodes β3-AR, mainly expressed in white adipose tissue, but also in the heart, brain, lungs, and liver ( Gao et al, 2017 ). Those genes and function therefore are novel targets of interests for further investigation.…”
Section: Discussionmentioning
confidence: 99%