<em>In vitro</em> evaluation and <em>in vivo</em> efficacy of nitroimidazole-sulfanyl ethyl derivatives against <em>Leismania</em> (<em>V.</em>) <em>braziliensis</em> and <em>Leishmania</em> (<em>L.</em>) <em>mexicana</em>

Abstract

In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leismania (V.) braziliensis and Leishmania (L.) mexicana 2 Metronidazole: Drug Repositioning Optimization against Leishmania spp. L. (V) braziliensis DL50 21 ug/mL L. (L) mexicana DL50 18 ug/mL Mice infected with Leishmania species: • Reduced toxicity • Less size of lesions • Longer survival time