&amp;lt;i&amp;gt;Burkholderia&amp;lt;/i&amp;gt; Cepacia Causing Nosocomial Urinary Tract Infection in Children

Lee, Ki Wuk; Lee, Sang Taek; Cho, Heeyeon

doi:10.3339/chikd.2015.19.2.143

Cited by 6 publications

(4 citation statements)

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“…[19,20] According to antibiotic susceptibility in our study, most sensitive antimicrobial agents were Piperacillin/tazobactam 98%, Meropenem 98%, Minocycline 85% and Cefotaxime 80% and resistant agents were resistivity of Amikacin 99%, Ampicillin 99%, Cefixime 95% and Aztreonam 90%. Our results were comparable to the studies conducted in past [21][22][23] Due to their innate resistance to the majority of antibiotics, including antibiotics, polymyxins B, and colistin, BCC infections present a challenge for appropriate antimicrobial therapy [24]. Ceftazidime, meropenem, and co-trimoxazole, either separately or in combination, have been identified as prefered medications [25].…”

Section: Discussionsupporting

confidence: 84%

Burkholderia Cepacia, an Emerging Nosocomial Pathogen in Neonates

Shaikh,

Khan

et al. 2023

PJMHS

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Aim: To determine the prevalence of burkholderia cepacia infection at neonatal intensive care unit at Liaquat University Hospital Hyderabad/ Jamshoro. Study Design: Retrospective study Place and Duration: Department of Pathology Diagnostic and Research Laboratory LUMHS, Hyderabad. August 2017-September 2018. Methods: Total 140 neonates were presented in this study. Each case's blood sample was extracted and prepared for five days of incubation on the BACT ALERT 3D at 37 degrees Celsius. Blood culture-verified BCC infections were examined in this investigation within the first 72 hours of admission. Analysis has been done on the nosocomial B. cepacia pattern's antibiotic susceptibility. All data was analysed using SPSS 23.0. Results: There were 85 (60.7%) females and 55 (39.3%) males among all cases. Neonates mean age was 9.25±4.31 days. Most of the neonates had normal mode of delivery 90 (64.3%) and C-section was in 50 (35.7%) cases. According to antibiotic susceptibility in our study, most sensitive antimicrobial agents were Piperacillin/tazobactam 98%, Meropenem 98%, Minocycline 85% and Cefotaxime 80% and resistant agents were resistivity of Amikacin 99%, Ampicillin 99%, Cefixime 95% and Aztreonam 90%. Conclusion: This study revealed the high prevalence of Burkholderia cepacia infection in neonatal intensive care unit patients, and urgent need for an effective Intervention to control this outbreak. Keywords: Burkholderia cepacia, Neonates, Antibiotic susceptibility, Nosocomial infection

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Section: Discussionsupporting

confidence: 84%

Burkholderia Cepacia, an Emerging Nosocomial Pathogen in Neonates

Shaikh,

Khan

et al. 2023

PJMHS

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“…1 Affect any age group in whom various predisposing factors are present. 2 But in this study, among the 3 isolation of B.cepacia complex there were two patients who had no history of any such urinary catheterization or any predisposing conditions leading to a nosocomial cause.…”

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confidence: 78%

Urinary Tract Infection in Tertiary Care Hospital in Kerala and Burkholderia Cepacia in Uncomplicated Uti

Mundangalam¹

2018

jebmh

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BACKGROUNDBurkholderia cepacia complex urinary infections are mostly reported in patients who had undergone procedures in hospital set up by contact with contaminated catheters or gel used for lubricating the catheter. Here with present isolation of Burkholderia cepacia complex in patients of uncomplicated UTI who did not have previous history of intervention in the urinary tract. MATERIALS AND METHODSFor reviewing the anti-microbial profile of the urinary pathogen, study was conducted on 1000 consecutive urine samples received in Clinical Microbiology laboratory. Samples were collected from the patients who presented to the outpatient department and from those who were admitted. Samples received included routine antenatal screening urine samples and samples collected from patients undergoing elective surgical procedures. Sterile wide mouthed urine containers used for collection of mid-stream urine. RESULTSOut of 1000 urine samples studied, 192 pure isolates satisfying significant urinary pathogen. Antibiotic susceptibility of all the isolates documented with Whonet 5.6. No pathogen could be separately isolated in 165 samples which yielded mixed growth due to probable contamination with perineal flora by improper collection of the urine sample.Bacterial isolates obtained included Escherichia coli, Klebsiella sp. Enterococci and Pseudomonas isolated commonly in the order. Fungi isolated were predominantly non-albicans Candida species. CONCLUSIONAntimicrobial surveillance plays a definite role in containment of resistant strains of bacteria causing urinary infections. Proper awareness among the health care providers regarding the spread of antibiotic resistance lead to rational prescription practices. Public awareness need to be emphasized through lay media about the unscrupulous self-medication which is contributing to resistance. The public needs to be re-assured about the nature of the condition that waiting for the antibiotic susceptibility study would not cause any excess signs and symptoms and damages.

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“…Burkholderia cepacia may be a causative pathogen for nosocomial UTI in pediatric patients with predisposing factors, and appropriate selection of antimicrobial therapy is necessary because of high levels of resistance to empirical therapy, including aminoglycosides. Over 14 years, 14 patients (male-tofemale ratio of 1:1) were diagnosed with B. cepacia UTI (urinary Tract Infection) (7). Outside the CF population, infection with B. cepacia complex is poorly understood apart from its presence in occasional point source outbreaks.…”

Section: Introductionmentioning

confidence: 99%

An Outbreak of Burkholderia Cepacia Septicemia in Neonatal Intensive Care Unit of a Tertiary Care Hospital, Peshawar

Abdullah

Khan

Amjad³

et al. 2021

Preprint

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Background: Burkholderia cepacia (formerly Pseudomonas) is a gram-negative bacillus that can remain viable in low-nutrient water and is typically found in soil and moist settings. It is one of the leading causes of sepsis in infants, and it is spread by human contact with contaminated medical devices and disinfectants. B. cepacia has emerged as a significant opportunistic pathogen in hospitalized and immunocompromised patients, colonizing the lungs of individuals with cystic fibrosis. Hospital outbreaks have been associated to infected faucets, nebulizers, disinfection solutions, multi-dose antibiotic vials, drinking water, distilled water, flowmeters, nasal sprays, and ultrasound gels. We describe our investigation and successful management of a nosocomial Burkholderia cepacia sepsis outbreak in a tertiary care hospital's newborn intensive care unit in Peshawar, Pakistan.Methodology: Blood samples from 50 newborns with sepsis were collected using a standardized approach and incubated using an automated blood culture system (BACT/Alert 3D and BACTEC 9050). Disk diffusion and the Minimum inhibitory concentration methods were used to test antimicrobial susceptibility. Gram staining was used to identify bacteria, and API (Analytical Profile Index) 20 NE was used to characterize them biochemically. Environmental and epidemiological investigations were also conduct to investigate the source and route of infection.Results: All of the 50 patients admitted in NICU (Neonatal Intensive Care Unit) were included in this study, and had lately-onset neonatal sepsis, with B. cepacia. During an epidemic in the NICU from 30th, April to 21st, June 2021, B. cepacia was isolated from over 45 blood samples. In total 45 neonates 17(35%) were female and 28 (65%) were male. Average age of neonates was 14.88 days. Antibiotic susceptibility testing was performed on Muller Hinton agar using Kirby Bauer's disc diffusion method and interpreted according to Clinical Laboratory Standard Institute (CLSI 2021) guidelines. As B. cepacia has intrinsic resistant to polymyxin class (colistin sulphate) of antibiotics, the susceptibility pattern of all isolates were almost similar i.e. showing resistance to tetracycline 100% (minocycline) and cephalosporin 3rd generation 100% (ceftazidime). The isolates were 100% sensitive to fluoroquinolones (levofloxacin), carbapenem 100% (meropenem), chloramphenicol 100% and sulfonamide 100% (co trimaxazole).Conclusion: In present study, the index case might have been exposed to infection due to an intravenous fluid utilized for fluid and electrolyte replacement for intravenous delivery were the source of the current nosocomial outbreak and physiological state of low immunity (preterm, low birth weight, and mechanical ventilation). The rest of the cases might have been exposed to this organism due to inadequate hand hygiene/improper cleaning and disinfection practices. Timely reporting and implementation of infection control measures can play a significant role in curtailing this outbreak.

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<i>Burkholderia</i> Cepacia Causing Nosocomial Urinary Tract Infection in Children

Cited by 6 publications

References 8 publications

Burkholderia Cepacia, an Emerging Nosocomial Pathogen in Neonates

Burkholderia Cepacia, an Emerging Nosocomial Pathogen in Neonates

Urinary Tract Infection in Tertiary Care Hospital in Kerala and Burkholderia Cepacia in Uncomplicated Uti

An Outbreak of Burkholderia Cepacia Septicemia in Neonatal Intensive Care Unit of a Tertiary Care Hospital, Peshawar

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