<i>Helicobacter Pylori</i> and Periodontal diseases: An update and proposal of a multidisciplinary clinical protocol

Abstract

Helicobacter Pylori has been closely linked to chronic gastritis, peptic ulcers and increased risk of gastric carcinoma. Oral cavity, in particular dental plaque in periodontal pockets, may be a possible reservoir harboring H. Pylori, and may therefore be involved in the gastric reinfection by the bacterium, even after triple therapy regimen. This report is an update of scientific data showing the potential localization of H. Pylori in the oral cavity of periodontitis patients. A multidisciplinary clinical protocol combining full-mouth disinfection and triple therapy is also suggested. This protocol could permit to enhance oral H. Pylori eradication.

Unconventional Causes of Conventional Oral Cancer

“…pylori as infectious agent and chronic inflammation as noninfectious agent, leading to gastric and pancreatic cancer [27] serve as the best examples of infection and inflammation leading to cancerous growth. Periodontal pocketing and inflammation helps in colonization of this species in urease rich sub-gingival biofilm which also serves as selective ecological niche for the urease producing bacteria helping it in recolonization and reinfection in gastric mucosa [28]. Activation of NF-κB mediates the expression of multiple genes involved in H. pylori-induced host responses, such as expression of interleukin (IL)-6, -8.…”