&amp;lt;i&amp;gt;In Vivo&amp;lt;/i&amp;gt; Sedative and Anxiolytic Activities of &amp;lt;i&amp;gt;Thunbergia erecta&amp;lt;/i&amp;gt; (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Begum, Anawara; Hossen, Abul; Moly, Ayasha Akter; Bhuiyan, Md. Mahbubur Rahman; Shahed-Al-Mahmud, Md.

doi:10.4236/pp.2019.104016

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…The extract showed significant reduction in sleep latency and increased thiopental sodium induced sleeping time, indicating sedative effect. Thiopental is known to enhance the inhibitory action of the GABA receptor that decreases neuronal activity (Begum et al, 2019). On the other hand, in hole cross test, the results showed dose dependent activity corroborating with the findings of thiopental sodium induced sleeping test.…”

supporting

confidence: 79%

Analgesic, anxiolytic and sedative-like activities of leaves of Alpinia calcarata Roscoe in mice

Ferdous¹,

Daula²,

Naznin³

et al. 2020

J. Med. Plants Res.

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The objectives of the study were to evaluate the analgesic, anxiolytic and sedative-like activities of methanol extract of leaves of Alpinia calcarata Roscoe in mice model. Analgesic activity was investigated using the acetic acid-induced writhing test and formalin-induced paw licking test. In vivo neuropharmacological effects, including anxiolytic and sedative effects were examined by open field, light-dark, elevated plus maze, thiopental sodium-induced sleeping time and hole cross tests behaviors in mice. The extract produced significant (p<0.001) reduction in writhing and licking response in acetic acid-induced writhing and formalin-induced paw licking tests, respectively. Administration at a dose of 400 mg/kg.bw of leaves extract significantly (p<0.001) attenuated anxiety-like behavior in mice by decreasing movement in open field, increasing the time spent and number of entries in the open arms of elevated plus maze, and a significant increase in the time spent in the illuminated compartment in the light box in the light-dark test. The extract significantly (p<0.01) potentiated thiopental sodium-induced sleep and reduced the number of sectional crossings relative to the control group, indicating sedative effects. Based on the results obtained from in vivo activities, the leaves of A. calcarata was found to be a potential source of new analgesic, anxiolytic and sedative compounds.

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supporting

confidence: 79%

Analgesic, anxiolytic and sedative-like activities of leaves of Alpinia calcarata Roscoe in mice

Ferdous¹,

Daula²,

Naznin³

et al. 2020

J. Med. Plants Res.

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“…When passed through humans at approximately 50 kg of body weight, the plants can be taken up to 2500-1 00 000 mg (2.5-100 g) to reach a moderate hazard according to the WHO [15] referring that doses of T. alata and T. erecta extracts under 2.5-100 g, should be saved for consumers. Concerning these data, usages of T. erecta reported [11][12][13]19] in cooking, eating as a vegetable and application of its leaves for a remedy of headache, should be carefully determined for the doses. However, it is not surprise that T. alata leaf extracts can have activity against Pseudomonas aeruginosa and have significant antibacterial activity against Salmonella typhi [20] , according to their biological activities including DNA damage in normal and poisoned PBMCs, which can be assumed to occur at plant concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…Bhuiyan et al [12] researched T. erecta, a medicinal plant with many reported phytochemicals and significant medicinal value and revealed that the methanol leaf extract has hypoglycemic effects in an animal model. The most recent research reported experimental results in swiss albino mice with T. erecta, which contained phytoconstituents, flavonoids, glycosides, tannins saponin, carbohydrates and alkaloids and possessed sedative and anxiolytic activity traditionally used in insomnia, depression and anxiety management [13] . Information on the two wellknown, representative species of Thunbergia mentioned above, T. laurifolia and T. grandiflora, is very important for natural methods for human health, which is a longlived concept.…”

mentioning

confidence: 99%

Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

Suwannakud¹,

Boonthai²,

Noikotr³

et al. 2021

ijps

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Saemram et al.: Efficiency Evaluation of Thunbergia alata and Thunbergia erectaThunbergia alata and Thunbergia erecta have been mostly used for ornamentation but have interesting other uses. However, toxicity and phytochemical studies of these plants are lacking. Therefore, phytochemicals of the two species were investigated by gas chromatography-mass spectrometry, cytotoxicity and genotoxicity were tested via 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide and comet assays in normal human peripheral blood mononuclear cells. Then, the extracts of the two species and their combination were applied to peripheral blood mononuclear cells poisoned with rice whisky and bathroom cleaner as toxic models in everyday life. The results showed that the major phytochemicals were 12.36 % and 24.90 % phytol in ethanol extracts of Thunbergia alata and Thunbergia erecta and 46.29 % and 43.47 % oleamide in hexane extracts of Thunbergia alata and Thunbergia erecta, respectively. Half-maximal inhibitory concentration values, which indicate toxicity in cells, were not detected for either species, but at the deoxyribonucleic acid level, the extracts induced significant deoxyribonucleic acid damage, shown by high Olive Tail Moment values in peripheral blood mononuclear cells (p<0.05). Biological activity of the extracts revealed by higher cell viability percentages and lower Olive Tail Moment values in the treatments (poisoned peripheral blood mononuclear cells treated with plant extracts) than the controls (poisoned peripheral blood mononuclear cells). Taking all the results together, Thunbergia alata and Thunbergia erecta extracts and their combination can be applied for many benefits in humans following properties that have been previously used and their phytochemicals but have limitations of doses.

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“…Medicinal plants are used to treat a lot of psychiatric disorders through their potential active phytochemicals [25] which have fewer side effects [26]. Since synthetic drugs reduce these disorders with a great number of side effects and sometimes they create addiction over these drugs which causes suicide [27]. To develop a potential neuropsychiatric drug with a tolerable number of side effects [28], we used several animal models for testing medicinal plants chemical constituents' efficacy by following phytochemical and pharmacological analysis [29].…”

Section: Discussionmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

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Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

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<i>In Vivo</i> Sedative and Anxiolytic Activities of <i>Thunbergia erecta</i> (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Cited by 11 publications

References 24 publications

Analgesic, anxiolytic and sedative-like activities of leaves of Alpinia calcarata Roscoe in mice

Analgesic, anxiolytic and sedative-like activities of leaves of Alpinia calcarata Roscoe in mice

Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

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