&amp;lt;i&amp;gt;Serratia marcescens&amp;lt;/i&amp;gt; as Opportunistic Pathogen and the Importance of Continuous Monitoring of Nosocomial Infection in Makah City, Saudi Arabia

Faidah, Hani; Ashgar, Sami S.; Barhameen, Abeer; El-Said, Hamdi M.; Elsawy, Abdelrahman

doi:10.4236/ojmm.2015.53013

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Though S. marcescens was previously viewed as an innocuous organism, later on, it has been reported as an etiological agent of hospital-associated infections including septicemia, meningitis, endocarditis, urinary tract, respiratory tract, bloodstream and wound infections 2 . Prevalence of S. marcescens in healthcare settings is increasing parallel with the emergence of multi-drug resistance 3 , 4 . Biofilm formation is one of the primary underlying mechanisms responsible for antibiotic resistance in S. marcescens .…”

Section: Introductionmentioning

confidence: 99%

Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins

Sethupathy

Sivagnanam

Selvaraj

et al. 2017

Sci Rep

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Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm potential of Actinidia deliciosa have been explored against S. marcescens clinical isolate (CI). A. deliciosa pulp extract significantly inhibited the virulence and biofilm production without any deleterious effect on the growth. Vanillic acid was identified as an active lead responsible for the QSI activity. Addition of vanillic acid to the growth medium significantly affected the QS regulated production of biofilm and virulence factors in a concentration dependent mode in S. marcescens CI, ATCC 14756 and MG1. Furthermore vanillic acid increased the survival of Caenorhabditis elegans upon S. marcescens infection. Proteomic analysis and mass spectrometric identification of differentially expressed proteins revealed the ability of vanillic acid to modulate the expression of proteins involved in S-layers, histidine, flagellin and fatty acid production. QSI potential of the vanillic acid observed in the current study paves the way for exploring it as a potential therapeutic candidate to treat S. marcescens infections.

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Section: Introductionmentioning

confidence: 99%

Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins

Sethupathy

Sivagnanam

Selvaraj

et al. 2017

Sci Rep

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“…Functional groups are metal adsorption sites including carboxylate (-COO − ), amide (-NH 2 ), phosphate (PO 4 ), thiols (-SH), and hydroxide (-OH) [9,14]. In some bioremediation studies, the presence of the S. marcescens bacterium has been related to the adsorption of heavy metals and radioactive elements because it produces different enzymes and other essential compounds that allow it to remove heavy metals from the environment [16]. S. marcescens is a facultatively anaerobic, Gram-negative, rod-shaped member of the Enterobacteriaceae family.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Study of the Effects of Temperature and pH on Lead Bioremoval Using Serratia marcescens

Lecca-Caballero,

Vega-Moreno,

Cabanillas-Chirinos

et al. 2023

Sustainability

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Heavy metal contamination of water is a widespread problem in Peru and represents a potential threat to the ecosystem. Bacteria are an ecological alternative to treating these effluents. This research aims to determine the influence of temperature and pH on the lead (Pb) bioremoval in surface water using Serratia marcescens under laboratory conditions. The sample was collected from a stream located in Santiago de Chuco City (Peru). Treatments (T) were carried out by combining pH (5 and 7) and temperature (25, 30, and 35 °C). The bacterial inoculum (S. marcescens) was 3 × 108 CFU/mL, which was constant in all treatments. The lead bioremoval evaluation was performed in an airlift bioreactor and the incubation time was 24 h. The total lead concentration was determined using atomic absorption spectrophotometry. The results show that treatment 6 (temperature: 35 °C, pH: 5, and inoculum: 3 × 108 UFC/mL) showed a better result than the other treatments, with a removal value of 63.94%. Furthermore, the total lead concentration decreased from an initial concentration of 0.268 mg Pb/L to a final value of 0.0964 mg Pb/L. These results are still above the allowed water value (15 µg/L) according to Peruvian standards. On the other hand, temperature and pH influenced lead removal from surface water when S. marcescens was used after a short incubation period (24 h). Although an attempt was made to improve lead bioremoval by varying two parameters, temperature and pH, future research is still needed to investigate the effect of different inoculum concentrations, the use of microbial consortia, and a broader range of physicochemical parameters.

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<i>Serratia marcescens</i> as Opportunistic Pathogen and the Importance of Continuous Monitoring of Nosocomial Infection in Makah City, Saudi Arabia

Abstract: The aim of this study was to the evaluation of frequency and distribution of Serratia marcescens in the hospital departments and determination of antimicrobial resistance of the isolated strains.

Cited by 2 publications

References 20 publications

Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins

Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins

An In Vitro Study of the Effects of Temperature and pH on Lead Bioremoval Using Serratia marcescens

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