<sup>99m</sup>Tc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar

Abstract

Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99m Tc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99m Tc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate.