AMPA and NMDA receptors mediate synaptic excitation in the rat’s inferior colliculus

Lei, Chun; Kelly, Jack B.; Wu, Shu Hui

doi:10.1016/s0378-5955(02)00370-2

Cited by 44 publications

(57 citation statements)

References 39 publications

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“…In the inferior colliculus (IC), studied here, in vitro and in vivo studies generally reinforce the view that AMPARs and NMDARs mediate early and late elements, respectively, of temporal response patterns (Faingold et al, 1989;Feldman and Knudsen, 1994;Zhang and Kelly, 2001;Ma et al, 2002;Wu et al, 2004). However, in vivo blockade of AMPARs in IC does not always eliminate early spikes as expected (Feldman and Knudsen, 1994;Zhang and Kelly, 2001), and in vitro studies of other systems reveal fast postsynaptic responses mediated by NMDARs (D'Angelo et al, 1990;Wolszon et al, 1997).…”

Section: Introductionsupporting

confidence: 69%

“…As in other systems (Sillito et al, 1990), previous work in IC has emphasized a strong linkage between onset components of sensory-evoked responses and AMPAR-mediated currents (Faingold et al, 1989;Feldman and Knudsen, 1994;Zhang and Kelly, 2001;Ma et al, 2002). Our results show that this linkage is weak in the mustached bat's IC: onset responses can be AMPAR mediated, NMDAR mediated, or both.…”

Section: Roles Of Ampars and Nmdars In Temporal Patterns Of Response supporting

confidence: 61%

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Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Sanchez¹,

Gans²,

Wenstrup³

2007

J. Neurosci.

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Section: Introductionsupporting

confidence: 69%

Section: Roles Of Ampars and Nmdars In Temporal Patterns Of Response supporting

confidence: 61%

Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Sanchez¹,

Gans²,

Wenstrup³

2007

J. Neurosci.

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“…We measured the ratio of peak NMDA current to peak AMPA current in the default model for a single excitatory input spike to be 0.0732 (NMDA/ AMPA; 5.00:68.28 pA). Ma et al (2002b) found that late (NMDA) and early (AMPA) currents in the rat IC had an average ratio of 0.58 (late/ early) with a range of ϳ0.08 -1.8. We predict that the NMDA-to-AMPA current ratio could be lower in bats, and thus more similar to our default model, due to the requirement for faster temporal processing.…”

Section: Inhibitory Inputs To the Model Dtnmentioning

confidence: 98%

Duration Tuning across Vertebrates

Aubie

Sayegh²,

Faure³

2012

J. Neurosci.

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Signal duration is important for identifying sound sources and determining signal meaning. Duration-tuned neurons (DTNs) respond preferentially to a range of stimulus durations and maximally to a best duration (BD). Duration-tuned neurons are found in the auditory midbrain of many vertebrates, although studied most extensively in bats. Studies of DTNs across vertebrates have identified cells with BDs and temporal response bandwidths that mirror the range of species-specific vocalizations. Neural tuning to stimulus duration appears to be universal among hearing vertebrates. Herein, we test the hypothesis that neural mechanisms underlying duration selectivity may be similar across vertebrates. We instantiated theoretical mechanisms of duration tuning in computational models to systematically explore the roles of excitatory and inhibitory receptor strengths, input latencies, and membrane time constant on duration tuning response profiles. We demonstrate that models of duration tuning with similar neural circuitry can be tuned with species-specific parameters to reproduce the responses of in vivo DTNs from the auditory midbrain. To relate and validate model output to in vivo responses, we collected electrophysiological data from the inferior colliculus of the awake big brown bat, Eptesicus fuscus, and present similar in vivo data from the published literature on DTNs in rats, mice, and frogs. Our results support the hypothesis that neural mechanisms of duration tuning may be shared across vertebrates despite species-specific differences in duration selectivity. Finally, we discuss how the underlying mechanisms of duration selectivity relate to other auditory feature detectors arising from the interaction of neural excitation and inhibition.

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“…Intracellular studies in rat, mouse, and gerbil brain slices have shown that excitatory and inhibitory postsynaptic responses can be elicited in the same ICC neuron by stimulation of the ascending afferent fiber tract, the lateral lemniscus (Wagner, 1996;Moore et al, 1998;Reetz and Ehret, 1999;Ma et al, 2002a). The excitatory response consists of two components.…”

Section: Introductionmentioning

confidence: 99%

Contribution of AMPA, NMDA, and GABA_AReceptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat

Lei²,

Kelly³

2004

J. Neurosci.

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The central nucleus of the inferior colliculus (ICC) is a major site of synaptic interaction in the central auditory system. To understand how ICC neurons integrate excitatory and inhibitory inputs for processing temporal information, we examined postsynaptic responses of ICC neurons to repetitive stimulation of the lateral lemniscus at 10 -100 Hz in rat brain slices. The excitatory synaptic currents mediated by AMPA and NMDA receptors and the inhibitory current mediated by GABA A receptors were pharmacologically isolated and recorded by whole-cell patch-clamp techniques. The response kinetics of AMPA receptor-mediated EPSCs and GABA A receptor-mediated IPSCs were similar and much faster than those of NMDA receptor-mediated EPSCs. AMPA EPSCs could follow each pulse of stimulation at a rate of 10 -100 Hz but showed response depression during the course of repetitive stimulation. GABA A IPSCs could also follow stimulus pulses over this frequency range but showed depression at low rates and facilitation at higher rates. NMDA EPSCs showed facilitation and temporal summation in response to repetitive stimulation, which was most pronounced at higher rates of stimulation. GABA A inhibition suppressed activation of NMDA receptors and reduced both the degree of AMPA EPSC depression and the extent of temporal summation of NMDA EPSCs. The results indicate that GABA A receptor-mediated inhibition plays a crucial role in maintaining the balance of excitation and inhibition and in allowing ICC neurons to process temporal information more precisely.

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AMPA and NMDA receptors mediate synaptic excitation in the rat’s inferior colliculus

Cited by 44 publications

References 39 publications

Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Duration Tuning across Vertebrates

Contribution of AMPA, NMDA, and GABA_AReceptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat

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AMPA and NMDA receptors mediate synaptic excitation in the rat’s inferior colliculus

Cited by 44 publications

References 39 publications

Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus

Duration Tuning across Vertebrates

Contribution of AMPA, NMDA, and GABAAReceptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat

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Contribution of AMPA, NMDA, and GABA_AReceptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat