Amperometric detection of bilirubin from a micro-sensing electrode with a synthetic bilirubin imprinted poly(MAA-co-EGDMA) film

Syu, Mei-Jywan; Chiu, Tz Cheng; Lai, Chune You; Chang, Yong Sheun

doi:10.1016/j.bios.2006.07.035

Cited by 44 publications

(13 citation statements)

References 24 publications

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“…MIP-based recognition elements were also prepared as layers or thin films by deposition or grafting onto the transducer platform [140,141]. The thickness of the film deposited on the transducer is important to obtain a good time response of the sensor.…”

Section: Mips’ Applicationsmentioning

confidence: 99%

Molecularly Imprinted Polymers: Present and Future Prospective

Vasapollo

Sole

Mergola

et al. 2011

IJMS

903

587

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Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.

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Section: Mips’ Applicationsmentioning

confidence: 99%

Molecularly Imprinted Polymers: Present and Future Prospective

Vasapollo

Sole

Mergola

et al. 2011

IJMS

903

587

View full text Add to dashboard Cite

show abstract

“…MIPs were used for several different applications, such as chromatographic stationary phases (Hishiya et al 2003), enantiomeric separation (Adbo et al 2001), solid-phase extraction (SPE) (Puoci et al 2008), and catalysis (Anderson et al 2005); MIPs were also used as receptors (Haupt et al 2003), antibodies (Svitel et al 2001), enzyme mimics (Nicholls et al 1996), and affinity and sensing materials (Syu et al 2006). In addition, in recent years, MIPs have been reported to be suitable as drug delivery systems (DDS) (Puoci et al 2007a), and as base excipients for controlled release devices of several drugs (Spivak 2005).…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers for α-Tocopherol Delivery

et al. 2008

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Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on α-tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for α-tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more α-tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.

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“…MIPs are stable polymers with molecular recognition abilities and resistant to a wide range of conditions (pH, organic solvents, temperature, pressure), and were used for several different applications, such as chromatographic stationary phases (Hishiya et al, 2003), enantiomeric separation (Adbo & Nicholls, 2001), solid-phase extraction (SPE) (El-Sheikh et al, 2010), and catalysis (Anderson et al, 2005); they were also used as receptors (Haupt, 2003), antibodies (Svitel et al, 2001), enzyme mimics (Nicholls et al, 1996), affinity and sensing materials (Syu et al, 2006), and, in recent years, pharmaceutical applications, such as drug discovery, drug purification, or drug delivery (Mosbach, 2006;Yu Y. et al, 2002;Caldorera-Moore & Peppas, 2009;Hilt & Byrne, 2004).…”

Section: Molecularly Imprinted Polymers (Mips): Highly Selective Matementioning

confidence: 99%