Amperometric enzymatic sensing of glucose using porous carbon nanotube films soaked with glucose oxidase

Rernglit, Waraporn; Teanphonkrang, Somjai; Suginta, Wipa; Schulte, Albert

doi:10.1007/s00604-019-3740-y

Cited by 25 publications

(12 citation statements)

References 29 publications

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“…The resulting sensors produced a glucose signal that was linear up to 40 mM, with a 50 µM detection limit. This glucose sensor proved to have a signal stability over 100 h of continuous operation [192]. Enzyme-based biosensors with CNTs were also designed for the detection of various other analytes, e.g., tyrosinase on polypyrrole-SWCNTs for dopamine detection [193], glutamate dehydrogenase-nicotinamide adenine dinucleotide on chitosan-MWCNTs for glutamate sensing [194], D-fructose dehydrogenase on 3,4-dihydroxybenzaldehyde on CNTs for fructose determination [195], anti-NS1antibodies on CNTs electrode for virus NS1 protein detection [196], and DNA probes on MWCNTs modified glass carbon electrode for miRNA sensing [197].…”

Section: Carbon Nanotubesmentioning

confidence: 97%

Functionalization of Carbon Nanomaterials for Biomedical Applications

Liu

Speranza

2019

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Over the past decade, carbon nanostructures (CNSs) have been widely used in a variety of biomedical applications. Examples are the use of CNSs for drug and protein delivery or in tools to locally dispense nucleic acids to fight tumor affections. CNSs were successfully utilized in diagnostics and in noninvasive and highly sensitive imaging devices thanks to their optical properties in the near infrared region. However, biomedical applications require a complete biocompatibility to avoid adverse reactions of the immune system and CNSs potentials for biodegradability. Water is one of the main constituents of the living matter. Unfortunately, one of the disadvantages of CNSs is their poor solubility. Surface functionalization of CNSs is commonly utilized as an efficient solution to both tune the surface wettability of CNSs and impart biocompatible properties. Grafting functional groups onto the CNSs surface consists in bonding the desired chemical species on the carbon nanoparticles via wet or dry processes leading to the formation of a stable interaction. This latter may be of different nature as the van Der Waals, the electrostatic or the covalent, the π-π interaction, the hydrogen bond etc. depending on the process and on the functional molecule at play. Grafting is utilized for multiple purposes including bonding mimetic agents such as polyethylene glycol, drug/protein adsorption, attaching nanostructures to increase the CNSs opacity to selected wavelengths or provide magnetic properties. This makes the CNSs a very versatile tool for a broad selection of applications as medicinal biochips, new high-performance platforms for magnetic resonance (MR), photothermal therapy, molecular imaging, tissue engineering, and neuroscience. The scope of this work is to highlight up-to-date using of the functionalized carbon materials such as graphene, carbon fibers, carbon nanotubes, fullerene and nanodiamonds in biomedical applications.

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Section: Carbon Nanotubesmentioning

confidence: 97%

Functionalization of Carbon Nanomaterials for Biomedical Applications

Liu

Speranza

2019

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“…[ 83 ] Besides, using the nanobiohybrid materials, highly sensitive electrochemical‐based bioelectronic sensing platforms, for example, based on the combination of the porous carbon nanofilms and enzymes for monitoring the glucose and the aptamer‐functionalized carbon nanomaterials for detecting the small molecules related to cancer have been reported and developed at the current moment. [ 84,85 ]…”

Section: Electrochemical‐based Bioelectronic Sensing Platforms Comprimentioning

confidence: 99%

Nanobiohybrid Material‐Based Bioelectronic Devices

Yoon

Shin

Lim

et al. 2020

Biotechnology Journal

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Biomolecules, especially proteins and nucleic acids, have been widely studied to develop biochips for various applications in scientific fields ranging from bioelectronics to stem cell research. However, restrictions exist due to the inherent characteristics of biomolecules, such as instability and the constraint of granting the functionality to the biochip. Introduction of functional nanomaterials, recently being researched and developed, to biomolecules have been widely researched to develop the nanobiohybrid materials because such materials have the potential to enhance and extend the function of biomolecules on a biochip. The potential for applying nanobiohybrid materials is especially high in the field of bioelectronics. Research in bioelectronics is aimed at realizing electronic functions using the inherent properties of biomolecules. To achieve this, various biomolecules possessing unique properties have been combined with novel nanomaterials to develop bioelectronic devices such as highly sensitive electrochemical-based bioelectronic sensing platforms, logic gates, and biocomputing systems. In this review, recently reported bioelectronic devices based on nanobiohybrid materials are discussed. The authors believe that this review will suggest innovative and creative directions to develop the next generation of multifunctional bioelectronic devices.

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“…Due to its simplicity, fast response, and easy miniaturization, an electrochemical method has been considered as the best for glucose and H 2 O 2 determination. ,− ,− Generally, the electrochemical biosensor is always working with the glucose oxidase (GOx) enzyme by virtue of its high selectivity and sensitivity. , However, the most common and serious problems for the enzymatic glucose sensor are its poor long-term stability, reproducibility, sensitivity to the environment, complicated immobilization procedure, and high cost of enzymes . Therefore, intense efforts have been devoted to the development of an economically viable and interference-free non-enzymatic sensor with high reproducibility that is free of interference and reliably fast that has been echoed by several researchers.…”

Section: Introductionmentioning

confidence: 99%

Negative Potential-Induced Growth of Surfactant-Free CuO Nanostructures on an Al–C Substrate: A Dual In-Line Sensor for Biomarkers of Diabetes and Oxidative Stress

Gowthaman

Arul

Lim

et al. 2020

ACS Sustainable Chem. Eng.

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Identifying a non-enzymatic sensor electrocatalyst for the accurate determination of biomolecules is a paramount task. The weird morphology of the nanomaterial may exhibit the remarkable activity to enhance the sensitivity of the electrode, and hence, tuning the shape of the nanomaterials is one of the important criteria for electrochemical sensors. Thus, this study sought to fabricate a non-enzymatic sensor with different CuO morphologies by an eco-friendly and facile approach. Different surfactant-free CuO nanostructures were fabricated on the highly conductive flexible aluminum-carbide substrate for the electrochemical assessment of glucose and H2O2 in human fluids. The CuO nanostructures were initially electrodeposited at −0.1, −0.3, −0.5, and −0.7 V and then calcined in air at 120 °C for 2 h. Different CuO nanostructures with a polygonal and cactus-like morphology were observed in scanning electron microscopic images. The as-fabricated electrodes were also characterized by X-ray diffraction (XRD), Xray photoelectron spectroscopy, and electrochemical impedance spectroscopy analysis.Texture coefficients (TC) of different CuO nanostructures were calculated from XRD analysis, and the CuO nanostructures grown at −0.5 V exhibited the highest TC with their texture along the (022) plane. The electrodes grown with different CuO nanostructures exhibited shapedependent electrocatalytic activity against glucose and H2O2, and the cactus-like CuO nanostructures grown at −0.5 V showed superior electrochemical behavior compared to that of the other nanostructures by showing superior sensitivities of 3892.6 and 2015.7 μA mM-1 cm-2, respectively, against glucose and H2O2. In addition, the sensor grown with a cactus-like CuO nanostructure exhibited high selectivity, storage capability, and good practicability. This sensor proved to be practical by determining glucose and H2O2 levels in human fluids. It is believed that the proposed electrochemical sensor will have a strong impact in the dual in-line sensing of biomarkers in both biological and clinical fields in the near future.

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Amperometric enzymatic sensing of glucose using porous carbon nanotube films soaked with glucose oxidase

Cited by 25 publications

References 29 publications

Functionalization of Carbon Nanomaterials for Biomedical Applications

Functionalization of Carbon Nanomaterials for Biomedical Applications

Nanobiohybrid Material‐Based Bioelectronic Devices

Negative Potential-Induced Growth of Surfactant-Free CuO Nanostructures on an Al–C Substrate: A Dual In-Line Sensor for Biomarkers of Diabetes and Oxidative Stress

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