Amphetamine-haloperidol discrimination: Effects of chronic drug treatment

Haenlein, Marianne; Caul, William F.; Barrett, Robert J.

doi:10.1016/0091-3057(85)90098-x

Cited by 24 publications

(13 citation statements)

References 11 publications

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“…Relative to choice responding that represents this midpoint on the continuum, responding on each drug-appropriate lever can either increase or decrease. This capability is ideal for determining whether a rebound can be observed and for defining the time course of drug-induced changes in cue state because both the primary effect of the drug and subsequent adaptive, rebound changes can be assessed (e.g., Haenlein et al 1985; Barrett and Smith 1988;Michaelis et al 1988; Barrett et al 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Animals were trained to discriminate between 0.25 mg/kg AM and 0.03 mg/kg HA. After replicating the results of the chronic drug treatment summarized above (Haenlein et al 1985), Barrett et al determined the time course of the effects of a single administration of 10 mg/kg AM and 1.0 mg/kg HA. They found that, following AM, the cue state changed in a biphasic fashion over time.…”

Section: Introductionmentioning

confidence: 99%

“…Haenlein et al (1985) trained animals to discriminate between the indirect dopamine agonist amphetamine (AM) and the dopamine antagonist haloperidol (HA). Twentyfour hours after treatment for 10 consecutive days with 10 mg/kg AM, animals responded predominantly on the HA-appropriate lever.…”

Section: Introductionmentioning

confidence: 99%

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Rebound responding following a single dose of drug using an amphetamine-vehicle-haloperidol drug discrimination

et al. 1996

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The purpose of this research was to characterize drug-induced rebound cue states using a three-choice, agonist-vehicle-antagonist drug-discrimination procedure. Rats were trained to discriminate among 0.50 mg/kg amphetamine (AM), distilled water (DW), and 0.03 mg/kg haloperidol (HA) in a three-lever drug discrimination task. Time-dependent changes in cue state were assessed following single doses of AM (5 and 10 mg/kg), HA (1 mg/kg), and cocaine (30 and 40 mg/kg). Consistent with expectations derived from the results of a study that used a two-lever AM-HA discrimination task, single doses of AM produced rebound responding on the HA-appropriate lever that was dose-dependent and peaked at 24 h following administration. In addition, cocaine substituted for AM at 0.5-2 h post-injection and then produced HA-like rebound responding that peaked at 24-36 h post-administration. Contrary to expectations, however, rebound AM-like responding did not occur following HA administration. Perhaps two- and three-choice discrimination tasks differ in their ability to characterize qualitative aspects of the post-haloperidol cue state. Knowledge of the time course of drug-induced adaptive processes, measured as withdrawal in the present research, is necessary for a complete description of a drug's effects and is important in understanding the effects of repeated drug administration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rebound responding following a single dose of drug using an amphetamine-vehicle-haloperidol drug discrimination

et al. 1996

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“…An alternative explanation for the behavior of the AM-treated animals is that the AM-induced withdrawal cue persisted throughout the 7 days during which the three testing sessions occurred and that the change in behavior observed reflects the effects of repeated testing without reinforcement. This possibility, however, seems unlikely given the earlier finding that HA-appropriate lever responding induced by ten administrations of a much larger dose of AM dissipated by 72 h after the final injection (Haenlein et al 1985;Barrett et al 1992).…”

Section: Discussionmentioning

confidence: 88%

Amphetamine-induced withdrawal responding: effects of repeated drug administration

1997

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The first purpose of this research was to assess withdrawal haloperidol-appropriate lever responding 24 h after a single administration of 0.35, 0.75, and 1.00 mg/kg amphetamine. Rats were trained to discriminate among 0.35 mg/kg amphetamine (AM), distilled water (DW), and 0.033 mg/kg haloperidol (HA) in a three-lever drug discrimination task. An increase in HA-appropriate lever responding occurred following the 1.00 mg/kg dose of AM but not after either of the lower doses. The second purpose was to determine the effect of repeated administration of 0.75 mg/kg AM. Two groups of animals were given five administrations of drug, one at an interdose interval (IDI) of 24 h and the other at an IDI of 48 h. Control animals were given injections of DW. Increased HA-appropriate lever responding occurred in both of the AM-treated groups. The magnitude of this effect tended to be less in the 48-h IDI group. Thus, even though HA-lever responding was not evident 24 h after a single administration of 0.75 mg/kg AM, it was produced by repeated administration of this dose, even at 48-h intervals.

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“…This procedure, previously described by Barrett (1985), Haenlein et al (1985), Holloway et al (1985), and Michaelis et al (1988), involved training animals to discriminate between two drugs representing opposite poles on a single stimulus continuum. In the Barrett (1985) and Haenlein et al (1985) studies, rats were trained to discriminate between amphetamine, an indirect dopamine agonist, and haloperidol, a dopamine antagonist. In the Holloway et al (1985) and Michaelis etal.…”

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confidence: 99%

Time dependent pentylenetetrazol-like cues subsequent to diazepam administration

Barrett

Smith

1988

Psychopharmacology

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Seventy male Sprague-Dawley rats were trained to discriminate which of two levers to press for milk reinforcement on a VI-20 schedule of reinforcement on the basis of whether they were injected subcutaneously with 0.75 mg/kg diazepam or 10.0 mg/kg pentylenetetrazol. Following discrimination acquisition, a dose-response function was generated for each drug during 5-min extinction periods. Subjects were then assigned to one of seven groups on the basis of their per cent responding during saline testing. Each group was injected with 5 mg/kg diazepam and then given a 5-min extinction test at intervals of 2, 4, 6, 8, 12, 16, 20, or 24 h subsequent to injection. The results indicated that at the shorter time intervals the animals responded on the diazepam lever. However, as the time interval between injection and testing lengthened, responding on the PTZ bar gradually increased until by 12 h following injection with diazepam the animals were responding as though they had received an injection of 5 mg/kg PTZ. Following this period of rebound, choice behavior returned to baseline by 24 h post-injection.

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Amphetamine-haloperidol discrimination: Effects of chronic drug treatment

Cited by 24 publications

References 11 publications

Rebound responding following a single dose of drug using an amphetamine-vehicle-haloperidol drug discrimination

Rebound responding following a single dose of drug using an amphetamine-vehicle-haloperidol drug discrimination

Amphetamine-induced withdrawal responding: effects of repeated drug administration

Time dependent pentylenetetrazol-like cues subsequent to diazepam administration

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