Amphetamine-Induced Place Preference in Humans

Abstract

Background-The conditioned place preference procedure is a widely used animal model of rewarding drug effects that, to date, has not been tested in humans. In this study, we sought to demonstrate that humans, like non-humans, would exhibit a preference for a place previously associated with amphetamine. Further, we investigated the relationship between conditioned place preference and the mood-altering effects of the drug.

Consumption of a highly palatable food induces a lasting place-conditioning memory in marmoset monkeys

“…Interestingly, the effect persisted for at least 15 days, an aspect that to date has only been consistently demonstrated for drug-related rewards. Considering that the CPP paradigm in now being established in non-human primates (Barros et al, 2013;Monclaro et al, 2014;Valentinuzzi et al, 2008;Wang et al, 2012) and humans (Childs and de Wit, 2009), future studies comparing different food items and evaluating possible long-term effects may play a significant role in elucidating the neural mechanisms underlying the overconsumption of highly palatable foods items (like chocolate).…”

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

“…Recently, place preference for amphetamines was demonstrated in humans (Childs and de Wit, 2009). Early research suggested an involvement of D1 dopamine receptors and NMDA-type glutamate receptors in the establishment of cocaine CPP, whereas the AMPA-type glutamate receptors seem to be involved in CPP expression as elucidated by using systemic delivery of specific AMPA and NMDA inhibitors (Cervo and Samanin, 1995).…”

Acquisition of Responses to a Methamphetamine-Associated Cue in Healthy Humans: Self-Report, Behavioral, and Psychophysiological Measures

“…Studies with laboratory animals have investigated both the acquisition and expression of drug conditioning, but in humans, most studies of drug cues investigate only the expression of drug-related responses, typically in currently or formerly dependent drug users. To date, only a few studies have examined the process of acquisition of conditioning with drugs in humans (eg, Winkler et al, 2011;Childs and de Wit, 2009;. To address this gap, we have developed a novel human drug conditioning paradigm and demonstrated that healthy volunteers acquire a behavioral preference for a stimulus paired with a single dose of a known drug of abuse (ie, methamphetamine (MA) ;Mayo et al, 2013).…”