Amphicrine (mixed adenoneuroendocrine carcinoma) of the duodenum and coexistent metastatic well differentiated neuroendocrine tumour

Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?

“…9 Analogous to this, amphicrine carcinoma represents a rare form of malignancy that is composed of neoplastic cells with dual exocrine and NE differentiation. These unique tumours are reported at various sites, [10][11][12][13][14][15][16][17][18][19][20][21][22] predominantly within the gastrointestinal tract. [10][11][12][13][14][15][16][17][18][19] Unlike mixed adenoneuroendocrine carcinoma (MANEC) (also known as mixed neuroendocrine-nonneuroendocrine neoplasm 23 ), amphicrine carcinomas comprise a single neoplastic population rather than an admixture of morphologically distinct NE and non-NE components.…”

“…These unique tumours are reported at various sites, [10][11][12][13][14][15][16][17][18][19][20][21][22] predominantly within the gastrointestinal tract. [10][11][12][13][14][15][16][17][18][19] Unlike mixed adenoneuroendocrine carcinoma (MANEC) (also known as mixed neuroendocrine-nonneuroendocrine neoplasm 23 ), amphicrine carcinomas comprise a single neoplastic population rather than an admixture of morphologically distinct NE and non-NE components. Carcinomas with this bivalent differentiation are not currently included in the classification of NE tumours of the prostate.…”