Amphioxus Tbx6/16 and Tbx20 embryonic expression patterns reveal ancestral functions in chordates

Belgacem, Mohamed R.; Escande, Marie‐Line; Escrivà, Héctor; Bertrand, Stéphanie

doi:10.1016/j.gep.2010.12.006

Cited by 19 publications

(11 citation statements)

References 33 publications

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“…Comparisons with the previous phylogenies of and Belgacem et al (2011) have indicated that the inclusion of Mga sequences in our data set had a profound influence on the performance of neighbor-joining analysis, which produced a monophyletic Tbx6/16 subfamily only in the presence of Mga sequences (data not shown). Interestingly, the same effect was not seen in maximum likelihood analysis, which produced a monophyletic Tbx6/16 subfamily irrespective of the presence of Mga sequences (data not shown).…”

Section: Analysis Of Syntenymentioning

confidence: 66%

“…Orthologous correspondences between chicken and medaka genes are and Amphi-Tbx6d2 were grouped together basal to vertebrate Tbx6/16 subfamily genes ( fig. 1), thereby substituting the Amphi-Tbx6/16 gene Belgacem et al 2011) as the closest chordate relatives of the vertebrate Tbx6/16-like genes.…”

Section: Analysis Of Syntenymentioning

confidence: 99%

“…tbx24, which was originally isolated as the gene mutated in zebrafish fused somites (fss) mutant (van Eeden et al 1996), was named as such because of the high degree of sequence divergence in its T-domain (Nikaido et al 2002). However, in later studies, it has repeatedly been shown that phylogenetically this gene is most closely related to the Tbx6 genes of tetrapods (Lardelli 2003;Yamada et al 2007;Takeuchi et al 2009;Belgacem et al 2011). This gene is also similar to the Tbx6 genes of mouse and Xenopus in terms of its expression within the early mesoderm (Chapman et al 1996;Uchiyama et al 2001) as well as its functions in defining somite boundaries during later stages (Watabe-Rudolph et al 2002;White et al 2003;Hitachi et al 2008).…”

Section: Zebrafish Tbx24 Gene Is An Ortholog Of Tetrapod Tbx6 Genesmentioning

confidence: 99%

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Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish

Ahn

You

Kim

2012

Molecular Biology and Evolution

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In any comparative studies striving to understand the similarities and differences of the living organisms at the molecular genetic level, the crucial first step is to establish the homology (orthology and paralogy) of genes between different organisms. Determination of the homology of genes becomes complicated when the genes have undergone a rapid divergence in sequence or when the involved genes are members of a gene family that has experienced a differential gain or loss of its constituents in different taxonomic groups. Organisms with duplicated genomes such as teleost fishes might have been especially prone to these problems because the functional redundancies provided by the duplicate copies of genes would have allowed a rapid divergence or loss of genes during evolution. In this study, we will demonstrate that much of the ambiguities in the determination of the homology between fish and tetrapod genes resulting from the problems like these can be eliminated by complementing the sequence-based phylogenies with nonsequence information, such as the exon-intron structure of a gene or the composition of a gene's genomic neighbors. We will use the Tbx6/16 subfamily genes of zebrafish (tbx6, tbx16, tbx24, and mga genes), which have been well known for the ambiguity of their evolutionary relationships to the Tbx6/16 subfamily genes of tetrapods, as an illustrative example. We will show that, despite the similarity of sequence and expression to the tetrapod Tbx6 genes, zebrafish tbx6 gene is actually a novel T-box gene more closely related to the tetrapod Tbx16 genes, whereas the zebrafish tbx24 gene, hitherto considered to be a novel gene due to the high level of sequence divergence, is actually an ortholog of tetrapod Tbx6 genes. We will also show that, after their initial appearance by the multiplication of a common ancestral gene at the beginning of vertebrate evolution, the Tbx6/16 subfamily of vertebrate T-box genes might have experienced differential losses of member genes in different vertebrate groups and gradual pooling of member gene's functions in surviving members, which might have prevented the revelation of the true identity of member genes by way of the comparison of sequence and function.

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Section: Analysis Of Syntenymentioning

confidence: 66%

Section: Analysis Of Syntenymentioning

confidence: 99%

Section: Zebrafish Tbx24 Gene Is An Ortholog Of Tetrapod Tbx6 Genesmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish

Ahn

You

Kim

2012

Molecular Biology and Evolution

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“…This domain includes cells that also express the vertebrate cardiac markers Hand and Tbx20 (refs 59, 104) and is thought to produce the branchial artery, a possible — but controversial — homo-logue of the heart with diffuse contractility 105 . These observations raise the possibility that the LCA of extant chordates had a CPF.…”

Section: Chordate Origins Of Branchiomeric Musclesmentioning

confidence: 99%

A new heart for a new head in vertebrate cardiopharyngeal evolution

Diogo

Kelly

Christiaen

et al. 2015

Nature

221

276

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It has been more than 30 years since the publication of the new head hypothesis, which proposed that the vertebrate head is an evolutionary novelty resulting from the emergence of neural crest and cranial placodes. Neural crest generates the skull and associated connective tissues, whereas placodes produce sensory organs. However, neither crest nor placodes produce head muscles, which are a crucial component of the complex vertebrate head. We discuss emerging evidence for a surprising link between the evolution of head muscles and chambered hearts — both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal field of vertebrate embryos. We consider the origin of this field in non-vertebrate chordates and its evolution in vertebrates.

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“…It was quickly realized that, although both As - T genes encode T-box proteins, As - T2 was more closely related to Tbx6/16 genes in vertebrates. Analyses of molecular phylogenies and gene synteny revealed that the Tbx6/16 subfamily has experienced a complex history of independent duplications and losses in different chordate lineages [3, 13]. Following two round of whole genome duplications in early vertebrates, the Tbx6/16 subfamily must have contained four distinct paralogs that were later differentially lost in teleosts and tetrapods.…”

Section: T-box 6-related Factorsmentioning

confidence: 99%

Regulation and evolution of muscle development in tunicates

Razy-Krajka

Stolfi

2019

EvoDevo

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For more than a century, studies on tunicate muscle formation have revealed many principles of cell fate specification, gene regulation, morphogenesis, and evolution. Here, we review the key studies that have probed the development of all the various muscle cell types in a wide variety of tunicate species. We seize this occasion to explore the implications and questions raised by these findings in the broader context of muscle evolution in chordates.

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Amphioxus Tbx6/16 and Tbx20 embryonic expression patterns reveal ancestral functions in chordates

Cited by 19 publications

References 33 publications

Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish

Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish

A new heart for a new head in vertebrate cardiopharyngeal evolution

Regulation and evolution of muscle development in tunicates

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