Amphiphilic Block Copolymer PCL-PEG-PCL as Stationary Phase for Capillary Gas Chromatographic Separations

Sun, Tao; Shuai, Xiaomin; Ren, Kaixin; Jiang, Xingxing; Chen, Yujie; Zhao, Xinyi; Song, Qianqian; Hu, Shaoqiang; Chi, Zhi-Qiang

doi:10.3390/molecules24173158

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…Peaks at 1.40–1.65, 2.32, and 4.06 ppm were assigned to methylene protons of −(CH 2 ) 3 –, −OCCH 2 –, and −CH 2 OOC– in the PCL units, respectively. The sharp peak at 3.65 ppm was attributed to methylene protons of −CH 2 CH 2 O– in PEG units of block copolymers . The acetal bond formation was confirmed by the characteristic peaks at 4.7–4.8 ppm assigned as methine protons of acetal groups and at 1.3 ppm from methyl protons of acetal groups.…”

Section: Resultsmentioning

confidence: 84%

“…The sharp peak at 3.65 ppm was attributed to methylene protons of −CH 2 CH 2 O− in PEG units of block copolymers. 22 The acetal bond formation was confirmed by the characteristic peaks at 4.7−4.8 ppm assigned as methine protons of acetal groups and at 1.3 ppm from methyl protons of acetal groups. The very weak peaks at 4.23 ppm were attributed to methylene protons of −O−CH 2 − in the PEG end-unit linked with the PCL blocks.…”

Section: Resultsmentioning

confidence: 92%

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Polymer-Based Dual-Responsive Self-Emulsifying Nanodroplets as Potential Carriers for Poorly Soluble Drugs

Zhang

Wang

et al. 2021

ACS Appl. Bio Mater.

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A biodegradable amphiphilic liquid polymer was designed to form self-emulsifying nanodroplets in water for delivering poorly soluble drugs. The polymer was composed of multiple short blocks of poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL) connected through acid-labile acetal linkages. With an overall average molecular weight of over 18 kDa, the polymer remained as a viscous liquid under room and physiological temperatures. Dispersing the polymer in an aqueous buffer gave rise to highly stable micelle-like nanodroplets with an average size of approximately 15−20 nm. The nanodroplet dispersions underwent reversible temperature-sensitive aggregation with cloud points ranging from 45 to 50 °C, depending on polymer concentration. Nuclear magnetic resonance (NMR) and dynamic light scattering analyses revealed that while the nanodroplets were stable at pH 7.4 for several days, hydrolysis of the acetal linkages in the polymer backbone was much accelerated under mildly acidic pH 5.0, resulting in the formation of large microdroplets. Nile red (NR), a poorly water-soluble fluorophore, can be solubilized in the nanodroplets, and efficient intracellular delivery of NR was achieved. The hydrophobic indocyanine green (ICG) was also encapsulated in the nanodroplets. Near-infrared (NIR) fluorescence imaging and in vivo biocompatibility of the ICG-loaded nanodroplets were demonstrated in mice. In summary, the self-emulsifying nanodroplets of amphiphilic liquid polymer would be a promising material system for poorly soluble drug delivery and imaging in vivo.

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Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 92%

Polymer-Based Dual-Responsive Self-Emulsifying Nanodroplets as Potential Carriers for Poorly Soluble Drugs

Zhang

Wang

et al. 2021

ACS Appl. Bio Mater.

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“…PCL-PEG-PCL stationary phase has a linear structure, which has been reported by our group. 30 As shown, the Star-PEG-PCL 2 column can separate almost all analytes except 2,6-dimethylphenol/2-ethylhexanoic acid (peaks 9/10) and dicyclohexylamine/methyl dodecanoate (peaks 11/12), showing its excellent resolving capability for the complex mixture. Regarding the retention behavior, the Star-PEG-PCL 2 column exhibited distinct elution order compared to other comparative columns.…”

Section: 1 Grob Test Mixturementioning

confidence: 80%

An Amphiphilic Star-Shaped Polymer (Star-PEG-PCL2) used as a Stationary Phase for GC

Chen

Chi

Zhang

et al. 2023

ACSi

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A star-shaped polymer (Star-PEG-PCL2) was synthesized to with PCL and PEG, and used as a stationary phase for gas chromatography. The statically coated Star-PEG-PCL2 column exhibited an efficiency of 2260 plates/m determined by naphthalene at 120 °C and moderate polarity. The Star-PEG-PCL2 column showed high resolution performance for isomers of a wide ranging polarity, including methylnaphthalenes, halogenated benzenes, nitrobenzene, phenols, and anilines, and displayed dual-nature selectivity for a mixture of 17 analytes. Also, the Star-PEG-PCL2 column exhibited good separation performance and column inertness for Grob test mixture and a series of cis-/trans-isomers. In addition, it exhibited advantageous separation performance over the commercial HP-35 and PEG-20M columns for chloroaniline and bromoaniline isomers through its unique three-dimensional framework. In conclusion, it has good potential as a new stationary phase for separating a variety of analytes because of its special structure and excellent separation performance.

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“…[23,24] In our previous works, the triblock copolymers including PCL-PDMS-PCL and PCL-PEG-PCL found that the improving chromatographic performance originated from the addition of PCL block. [25][26][27] However, as with most hydroxy terminated polymeric materials, the relatively low thermal stability of PCL necessitates its functionalization.…”

Section: Introductionmentioning

confidence: 99%

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

Chi

Chen

et al. 2023

Chemistry & Biodiversity

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This work firstly reported a new polycaprolactone based material functionalized with guanidinium ionic liquid (PCL‐GIL) as the stationary phase with high resolution performance for capillary gas chromatography (GC). It is composed of polycaprolactone (PCL) and guanidinium ionic liquid (GIL) with amphiphilic conformation. The PCL‐GIL capillary column coated by static method exhibited high column efficiency of 3942 plates/m and moderate polarity. As a result, the PCL‐GIL column exhibited high‐resolution capability. For a mixture of 27 analytes with a wide ranging polarity and outperformed the PCL‐2OH and HP‐35 columns, showing its advantageous separation capability for analytes of diverse types. Moreover, the PCL‐GIL column showed high resolving capability for various positional isomers and cis‐/trans‐isomers, including alkylbenzenes, chlorobenzenes, naphthalenes, bromonitrobenzenes, chloronitrobenzenes, benzaldehydes, phenols, alcohols, respectively. In a word, PCL derivatized by GIL units as a new type of stationary phase has a promising future in GC separations.

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Amphiphilic Block Copolymer PCL-PEG-PCL as Stationary Phase for Capillary Gas Chromatographic Separations

Cited by 14 publications

References 41 publications

Polymer-Based Dual-Responsive Self-Emulsifying Nanodroplets as Potential Carriers for Poorly Soluble Drugs

Polymer-Based Dual-Responsive Self-Emulsifying Nanodroplets as Potential Carriers for Poorly Soluble Drugs

An Amphiphilic Star-Shaped Polymer (Star-PEG-PCL2) used as a Stationary Phase for GC

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

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