Amphiphilic block copolymers for drug delivery

Adams, Monica; Lavasanifar, Afsaneh; Kwon, Glen S.

doi:10.1002/jps.10397

Cited by 991 publications

(699 citation statements)

References 79 publications

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“…Yield: 96%. 1 2.5 Synthesis of PMMA-b-PHEMA. This block copolymer was synthesized in two steps: ATRP polymerization of protected HEMA using PMMA-Cl as macroinitiator, followed by the deprotection reaction.…”

Section: Synthesis Of Hema-tbdmsmentioning

confidence: 99%

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Synthesis, Thermal Behavior, and Aggregation in Aqueous Solution of Poly(methyl Methacrylate)-B-Poly(2-Hydroxyethyl Methacrylate)

Acevedo¹,

Martínez

Olea³

2013

J. Chil. Chem. Soc.

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Amphiphilic block copolymers of poly(methyl methacrylate) PMMA and poly(2-hidroxyethyl methacrylate) PHEMA were synthesized by a two-step atom transfer radical polymerization (ATRP). Copolymers with various degrees of polymerization and different relative block sizes were obtained. The structure of the resulting polymers have been characterized and verified by FT-IR and 1 H-NMR, molecular weight were determined by size exclusion chromatography analyses. The thermal properties of these polymers were investigated by differential scanning calorimetry DSC and thermogravimetric analysis TGA. The glass transition temperature of mono halogenated PMMA increases from 116 ºC to 123 ºC with increasing molecular weight, whereas the glass transition temperature of block copolymers depends slightly on polymer structure. The derivatives of TGA curves indicate that thermal degradation occurs in one stage. The self-assembly of PMMA-b-PHEMA in aqueous solution have been investigated by fluorescence probing methods. The critical micelle concentrations are in the range 10 -6 -10 -7 M. The micropolarity sensed by pyrene is higher than in aggregates formed by block copolymers based on polystyrene.

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Section: Synthesis Of Hema-tbdmsmentioning

confidence: 99%

“…Over the last decades much attention has been devoted to amphiphilic block copolymers because of their potential applications in drug delivery [1][2][3][4][5][6] , imaging, catalysis, etc. One of the main properties of these copolymers is the ability to self-assemble in aqueous solution forming core-shell structures [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Thermal Behavior, and Aggregation in Aqueous Solution of Poly(methyl Methacrylate)-B-Poly(2-Hydroxyethyl Methacrylate)

Acevedo¹,

Martínez

Olea³

2013

J. Chil. Chem. Soc.

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“…Block copolymers have also found application in biomaterials for both mechanical [68][69][70] and biological properties. There are many biological applications for block copolymers, including micelles for drug delivery [71][72][73][74], spacing bioactive groups on a surface [54,59,60,75,76] and controlling cellular and protein adhesion [25,[51][52][53]57,[77][78][79][80][81]. Despite the wide variety of applications, there does not appear to have been a systematic exploration of the structure-property relationship between block copolymers and biological systems.…”

Section: (C) Block Copolymers As Biomaterialsmentioning

confidence: 99%

Designing nanostructured block copolymer surfaces to control protein adhesion

Schricker

Palacio

Bhushan

2012

Phil. Trans. R. Soc. A.

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The profile and conformation of proteins that are adsorbed onto a polymeric biomaterial surface have a profound effect on its in vivo performance. Cells and tissue recognize the protein layer rather than directly interact with the surface. The chemistry and morphology of a polymer surface will govern the protein behaviour. So, by controlling the polymer surface, the biocompatibility can be regulated. Nanoscale surface features are known to affect the protein behaviour, and in this overview the nanostructure of self-assembled block copolymers will be harnessed to control protein behaviour. The nanostructure of a block copolymer can be controlled by manipulating the chemistry and arrangement of the blocks. Random, A-B and A-B-A block copolymers composed of methyl methacrylate copolymerized with either acrylic acid or 2-hydroxyethyl methacrylate will be explored. Using atomic force microscopy (AFM), the surface morphology of these block copolymers will be characterized. Further, AFM tips functionalized with proteins will measure the adhesion of that particular protein to polymer surfaces. In this manner, the influence of block copolymer morphology on protein adhesion can be measured. AFM tips functionalized with antibodies to fibronectin will determine how the surfaces will affect the conformation of fibronectin, an important parameter in evaluating surface biocompatibility.

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“…Several systems such as liposomes (Fig 4), polymeric nanoparticles (Fig 2), polymeric nanogels, solid lipid nanoparticles (Fig 3) and polymeric micelles (Fig 5) have been investigated in systemic delivery [5,[11][12][13]. Up to now, liposomes and polymeric nanoparticles are most generally exploited for brain applications [14].…”

Section: Systemic Drug Delivery Systemsmentioning

confidence: 99%

Brain Drug Delivery Systems for Neurodegenerative Disorders

Garbayo

Ansorena

Blanco-Prieto

2012

CPB

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Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome. There has recently been growing interest in the development of drug delivery systems (DDS) for local or systemic brain administration. DDS are able to improve the pharmacological and therapeutic properties of conventional drugs and reduce their side effects. The present review provides a concise overview of the recent advances made in the field of brain drug delivery for treating neurodegenerative disorders. Examples include polymeric micro and nanoparticles, lipidic nanoparticles, pegylated liposomes, microemulsions and nanogels that have been tested in experimental models of Parkinson's, Alzheimer's and Hungtinton's disease. Overall, the results reviewed here show that DDS have great potential for NDs treatment.

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Amphiphilic block copolymers for drug delivery

Cited by 991 publications

References 79 publications

Synthesis, Thermal Behavior, and Aggregation in Aqueous Solution of Poly(methyl Methacrylate)-B-Poly(2-Hydroxyethyl Methacrylate)

Synthesis, Thermal Behavior, and Aggregation in Aqueous Solution of Poly(methyl Methacrylate)-B-Poly(2-Hydroxyethyl Methacrylate)

Designing nanostructured block copolymer surfaces to control protein adhesion

Brain Drug Delivery Systems for Neurodegenerative Disorders

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