Amphiphilic block copolymers: From synthesis including living polymerization methods to applications in drug delivery

Amphiphilic Polypeptides Obtained by the Post-Polymerization Modification of Poly(Glutamic Acid) and Their Evaluation as Delivery Systems for Hydrophobic Drugs

“…In this study, we aimed at the synthesis of amphiphilic (glyco)polypeptides by the post-polymerization modification of poly(glutamic acid), the formation and characterization of nanoparticles from the polymers obtained as well as their in vitro biological evaluation. Given that nanoparticles formed from the amphiphilic nanoparticles are known to be suitable for the effective encapsulation of hydrophobic drugs [ 43 ], the synthesized amphiphilic (glyco)polypeptides were examined for their potential applicability as delivery systems for paclitaxel (PTX).…”

Amphiphilic Block Copolymer Nanostructures as a Tunable Delivery Platform: Perspective and Framework for the Future Drug Product Development

“…The current status and challenges of amphiphilic block copolymer-based delivery platforms (such as micelles, polymersomes, and polymer nanoparticles) have been discussed here. Furthermore, these topics have also been extensively covered in recent review articles. ,,,,− Here, we will further focus primarily on the future of these block cocopolymers, in particular, those aspects that require further development for translating a proof-of-concept into a commercially viable platform based on polymersomes, which includes a discussion of our tunable delivery platform (called ATP) specifically the case of ACM-001 discussed in the section below.…”

“…CRP involves chain extension with the second monomer, after the first monomer has polymerized, without terminating or purifying the intermediates. CRP techniques that garnered attention in the recent past are nitroxide-mediated polymerization (NMP), atom transfer radical polymerization (ATRP), and reversible addition–fragmentation polymerization (RAFT). ,, These advanced polymerization techniques improve polymer design and synthesis diversity, yet with well-controlled molecular weight and architectures. While the NMP does not involve any metal in the polymer synthetic process, it is the least versatile due to stable dormant alkoxyamine making it difficult for many monomers to polymerize, and its slow kinetics require high temperatures (>120 °C) and bulk solutions.…”

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

“…As a result, the development of modern DDS can increase patient confidence and the effectiveness of treatment techniques. [3][4][5] DDS is the delivery of a specific drug transmitter or carrier capable of transporting medicinal chemicals to the desired tissue or organ. The pharmaceutical industry and academic research institutions devote most of their resources to the development of polymeric micelle (PM) as drug carriers.…”

“…The active components of the drug are then incorporated into the extracellular matrix and interact with diseased organs. As a result, the development of modern DDS can increase patient confidence and the effectiveness of treatment techniques [3–5] . DDS is the delivery of a specific drug transmitter or carrier capable of transporting medicinal chemicals to the desired tissue or organ.…”