Amphiphilic block poly(propylene carbonate)‐block‐allyloxypolyethyleneglycol copolymer based shell cross‐linked micelles for controlled release of drug

Abstract

Amphiphilic block poly(propylene carbonate)‐block‐allyloxypolyethyleneglycol (PPC‐b‐APEG) copolymer was synthesized by the click chemistry, and its structure were characterized. PPC‐b‐APEG can self‐assemble into micelles without emulsifier in water. Shell cross‐linked micelles were obtained by the reaction of the allyloxy groups, which were exposed on the outer of the PPC‐b‐APEG micelles, and N‐vinylpyrrolidone (NVP). The morphology and size of the micelles before and after cross‐link reactions were characterized. The research result shows that the shell cross‐linking could improve the stability of micelles. The particle size of uncross‐linked micelle was about 800 nm. The size of cross‐linked micelles increased with increasing amount of cross‐linking degree. To better evaluate the release behavior of PPC‐b‐PEG copolymer, doxorubicin (DOX)‐loaded micelles were synthesized using DOX as the model drug. Results showed that the DOX releasing rate decreased with increasing of NVP. The shell cross‐linking do decrease the burst release behaviours of DOX and reduce the DOX release rate.

Reduction-Responsive Anticancer Nanodrug Using a Full Poly(ethylene glycol) Carrier

“…To adjust the hydrophilic−hydrophobic ratio, a series of other PEG derivatives with different molar ratios of PEG 200 / PEG 10k (25:1 to 800:1) were synthesized by copolymerizing PEG 200 and PEG 10k with MSA (Table 1). It is revealed in the nuclear magnetic resonance ( 1 H and 13 C NMR, Figures S2− S9) spectroscopy that the PEG 200 /PEG 10k ratio in polymer is very close to the feed ratio, demonstrating the successful synthesis of the PEG derivatives. Moreover, as presented in the 1 H NMR spectra, the hydrogen peak of mercapto groups in the PEG derivatives was found at 2.28 ppm, suggesting that the mercapto groups of the PEG derivatives remain chemically stable during the polymerization process.…”

“…Hence, effective chemically cross-linked micelles are required to improve their stability in blood. Among the current cross-linking strategies, that is, core cross-linking, , interfacial cross-linking, , and shell cross-linking, , the core cross-linking does not alter the physicochemical properties of the micellar shell, making it the most facile yet effective way to stabilize the micelle.…”

Synthesis of CO2‐based functional poly(carbonate‐co‐lactide)

“…One‐pot/one‐step ter‐polymerization of CO 2 , EPO, and LA was also realized to form poly(aliphatic carbonate‐co‐lactide) copolymer (simplified as APCLA) with polymer‐loaded bi‐metal catalyst (PBM), 11 rare earth coordination catalyst, 12 zinc adipate, 13 and salenCo catalysts, 14 remarkable improvements either in biodegradability or thermal resistance performance of the ter‐polymer were developed relative to APC. However, due to the inherent hydrophobicity and inertness of APC block and PLA block, APCLA has poor hydrolysis and post‐polymerization modification performance, which confined its use in value‐added fields such as functional materials, 15 drug‐loading in biomedicine, 16 and nanotechnologies 17 . Introduction of pendant functional groups into aliphatic polycarbonates by the direct copolymerization of CO 2 and functional epoxides (including terminal epoxides, glycidyl ethers, 4‐substituted cyclohexene oxides, and other functional alicyclic epoxides), allowing for the tailoring of material properties, such as solubility, biodegradability, stimuli–response, and self‐healing ability, as well reviewed by Darensbourg 18 and Frey 19 .…”