Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy

Martino, Antonio Di; Sedlařík, Vladimír

doi:10.1016/j.ijpharm.2014.08.014

Cited by 66 publications

(42 citation statements)

References 37 publications

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“…The change with pH can be ascribed to the protonation/deprotonation of the remaining free amino groups of CS that change the electrostatic interaction among the chains, resulting in particles with different properties and CAC . No sign of aggregation was observed for the hydrophilic derivative (L‐CS‐GLY 40 ) even at higher concentrations.…”

Section: Resultsmentioning

confidence: 99%

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Pedro

Pereira

Goycoolea

et al. 2017

J of Applied Polymer Sci

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In this study, pH‐responsive amphiphilic chitosan (CS) nanoparticles were used to encapsulate quercetin (QCT) for sustained release in cancer therapy. The novel CS derivatives were obtained by synthesis with 2,3‐epoxy‐1‐propanol, also known as glycidol, followed by acylation with dodecyl aldehyde. Characterization was performed by spectroscopic, viscosimetric, and size‐determination methods. Critical aggregation concentration, morphology, entrapment efficiency, drug release profile, cytotoxicity, and hemocompatibility studies were also carried out. The average size distribution of the self‐assembling nanoparticles measured by dynamic light scattering ranged from 140 to 300 nm. In vitro QCT release and Korsmeyer–Peppas model indicated that pH had a major role in drug release. Cytotoxicity assessments indicated that the nanoparticles were non‐cytotoxic. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay further revealed that QCT‐loaded nanoparticles could inhibit MCF‐7 cell growth. In vitro erythrocyte‐induced hemolysis indicated the good hemocompatibility of the nanoparticles. These results suggest that the synthesized copolymers might be potential carriers for hydrophobic drugs in cancer therapy. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45678.

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Section: Resultsmentioning

confidence: 99%

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Pedro

Pereira

Goycoolea

et al. 2017

J of Applied Polymer Sci

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“…These grafted chitosans revealed good anti-coagulant activity and blood compatibility along with the absence of cell toxicity and inflammatory processes. An analogous grafting of poly(lactides) onto the chitosan macromolecule was also implemented in a medium of the mixture of DMFA/water solution of CH 3 COOH [202]. A blend of N-ethyl-N'-(dimethylaminopropyl) carbodiimide hydrochloride with N-hydroxysuccinimide was utilized as the condensing system.…”

Section: Chitosan Modification With 'Activated'mentioning

confidence: 99%

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

Farion¹,

Бурдуковский²,

Kholkhoev³

et al. 2018

Express Polym. Lett.

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“…In the "grafting to" method, pre-synthesized end-functional PLA chains are chemically bound onto CS via its amino or hydroxyl functionalities [23], whereas, in the "grafting from" method, the ring-opening polymerization of the lactide monomer is carried out from the CS functional groups [24,25]. Amphiphilic CS-g-PLLA copolymers have been used as drug carriers [26][27][28][29], however, only very few studies have employed CS-g-PLLA copolymers in tissue engineering to develop fibrous [25] or porous scaffolds [30]. Cytotoxicity experiments on electrospun CS-g-PLLA fibers using fibroblast cells showed that the graft copolymers with the higher LLA content present high cell viability, higher than CS alone, and comparable to that of pure PLLA [25], while mechanical testing of the samples showed that the CS-g-PLA fibrous scaffolds exhibit improved tensile strength and modulus, rendering them promising for tissue engineering applications [31].…”

mentioning

confidence: 99%

Biodegradable Chitosan-graft-Poly(l-lactide) Copolymers For Bone Tissue Engineering

et al. 2020

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The design and synthesis of new biomaterials with adjustable physicochemical and biological properties for tissue engineering applications have attracted great interest. In this work, chitosan-graft-poly(l-lactide) (CS-g-PLLA) copolymers were prepared by chemically binding poly(l-lactide) (PLLA) chains along chitosan (CS) via the “grafting to” approach to obtain hybrid biomaterials that present enhanced mechanical stability, due to the presence of PLLA, and high bioactivity, conferred by CS. Two graft copolymers were prepared, CS-g-PLLA(80/20) and CS-g-PLLA(50/50), containing 82 wt % and 55 wt % CS, respectively. Degradation studies of compressed discs of the copolymers showed that the degradation rate increased with the CS content of the copolymer. Nanomechanical studies in the dry state indicated that the copolymer with the higher CS content had larger Young modulus, reduced modulus and hardness values, whereas the moduli and hardness decreased rapidly following immersion of the copolymer discs in alpha-MEM cell culture medium for 24 h. Finally, the bioactivity of the hybrid copolymers was evaluated in the adhesion and growth of MC3T3-E1 pre-osteoblastic cells. In vitro studies showed that MC3T3-E1 cells exhibited strong adhesion on both CS-g-PLLA graft copolymer films from the first day in cell culture, whereas the copolymer with the higher PLLA content, CS-g-PLLA(50/50), supported higher cell growth.

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Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy

Cited by 66 publications

References 37 publications

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

Biodegradable Chitosan-graft-Poly(l-lactide) Copolymers For Bone Tissue Engineering

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