Amphiphilic conetworks: Definition, synthesis, applications

Erdődi, Gábor; Kennedy, Joseph P.

doi:10.1016/j.progpolymsci.2005.11.001

Cited by 268 publications

(109 citation statements)

References 96 publications

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“…Amphiphilic co-networks undergo massive conformational rearrangements virtually instantaneously when transferred from aqueous to organic liquids and vice versa ("smart" medium-responsive microstructures). Figure 1 helps to visualize the massive structural rearrangements that occur rapidly and reversibly upon change of the surrounding medium from tetrahydrofuran, to water, to hydrocarbon (Erdodi and Kennedy 2006). This adaptation to the milieu may explain the biocompatibility of certain of our APCNs.…”

Section: The Ideal Amphiphilic Membranementioning

confidence: 99%

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

Erdődi

Kang

Yalcin

et al. 2008

Biomed Microdevices

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This paper describes the design and preparation of the non-biological components (the "hardware") of a conceptually novel bioartificial pancreas (BAP) to correct diabetes. The key components of the hardware are (1) a thin (5-10 microm) semipermeable amphiphilic co-network (APCN) membrane [i.e., a membrane of cocontinuous poly(dimethyl acryl amide) (PDMAAm)/polydimethylsiloxane (PDMS) domains cross-linked by polymethylhydrosiloxane (PMHS)] expressly created for macroencapsulation and immunoisolation of a tissue graft; (2) an electrospun nanomat of PDMS-containing polyurethane to reinforce the water-swollen APCN membrane; and (3) a perforated hollow-ribbon nitinol scaffold to stiffen and provide geometric stability to the construct. The reinforcement of water-swollen hydrogels with an electrospun nanomat is a generally applicable new method for hydrogel reinforcement. Details of device design and preparation are discussed. The advantages and disadvantages of micro- and macro-immunoisolation are analyzed, and the requirements for the ideal immunoisolatory membrane are presented. Burst pressure, and glucose and insulin permeabilities of representative devices have been determined and the effect of device composition and wall thickness on these properties is discussed.

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Section: The Ideal Amphiphilic Membranementioning

confidence: 99%

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

Erdődi

Kang

Yalcin

et al. 2008

Biomed Microdevices

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“…Furthermore, the introduction of hydrophobic segments is known to be beneficial to reinforce the mechanical properties of the swollen networks. [23] Here, we report on the controlled synthesis of amphiphilic netP[N,N-dimethylamino-2-ethyl methacrylate-g-poly(e-caprolactone)] netP(DMAEMA-g-PCL) hydrogels through the combination of ring-opening polymerization (ROP) and atom-transfer radical polymerization (ATRP). To the best of our knowledge, such amphiphilic co-networks made of pHand temperature-sensitive water-soluble poly(aminoalkylmethacrylate) segments and biodegradable aliphatic polyester cross-linkers has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Novel Biodegradable Adaptive Hydrogels: Controlled Synthesis and Full Characterization of the Amphiphilic Co‐Networks

Mespouille

Coulembier

Paneva

et al. 2008

Chemistry A European J

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Adaptive and amphiphilic poly(N,N-dimethylamino-2-ethyl methacrylate-graft-poly[epsilon-caprolactone]) co-networks (netP(DMAEMA-g-PCL)) were synthesized from a combination of controlled polymerization techniques. Firstly, PCL cross-linkers were produced by ring-opening polymerization (ROP) of epsilon-CL initiated by 1,4-butane-diol and catalyzed by tin(II) 2-ethylhexanoate ([Sn(Oct)2]), followed by the quantitative esterification reaction of terminal hydroxyl end-groups with methacrylic anhydride. Then, PCL cross-linkers were copolymerized to DMAEMA monomers by atom-transfer radical polymerization (ATRP) in THF at 60 degrees C using CuBr complexed by 1,1,4,7,10,10-hexamethyltriethylenetetramine (HMTETA) and 2-ethyl isobutyrylbromide (EiBBr) as catalytic complex and initiator, respectively. A comprehensive study of gel formation was carried out by employing dynamic light scattering (DLS) to determine the gel point as a function of several parameters and to characterize the viscous solutions obtained before the gel point was reached. The evolution of the mean diameters was compared to a model previously developed by Fukuda and these attest to the living formation of the polymer co-network. Furthermore, we also demonstrated the reliability of ATRP for producing well-defined and homogeneous polymer co-networks by the smaller deviation from Flory's theory in terms of cross-linking density. For sake of clarity, the impact of polymerization techniques over the final structure and, therefore, properties was highlighted by comparing two samples of similar composition, but that were produced by either ATRP or thermal-initiated free-radical polymerization (FRP).

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“…Amphiphilic polymer conetworks, consisting of hydrophilic and hydrophobic chains covalently bonded to each other, represent a relatively new class of promising materials for applications such as pervaporation membranes, contact lenses, drug delivery systems, biomedical scaffolds for tissue engineering, and supports for catalysts [33]. The amphiphilic nature of these new crosslinked polymers is indicated by their swelling ability in both aqueous and organic media without losing their dimensional stability and without encountering macroscopic phase separation or polymer leaching [34,35].…”

Section: Introductionmentioning

confidence: 99%

“…The amphiphilic nature of these new crosslinked polymers is indicated by their swelling ability in both aqueous and organic media without losing their dimensional stability and without encountering macroscopic phase separation or polymer leaching [34,35]. The amphiphilic conetworks based on PDMS and some hydrophilic components have shown to at least partly provide bicontinuous or interpenetrating phase morphologies for long-term biocompatibility [33,[36][37][38]. Amphiphilic polymer conetworks have been a successful way to make the surfaces and interiors of a polysiloxane network more hydrophilic.…”

Section: Introductionmentioning

confidence: 99%

Improved Hydrophilicity from Poly(ethylene glycol) in Amphiphilic Conetworks with Poly(dimethylsiloxane)

Gui

Zhang

Kumar³

et al. 2009

Silicon

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This paper focuses on the improvement of hydrophicility and water content of poly(dimethylsiloxane) (PDMS) by bonding a hydrophilic macromer, hydroxyl-terminated linear poly(ethylene glycol) (PEG), into a highly hydrophobic macromer, hydroxyl-terminated linear PDMS to prepare amphiphilic conetworks (APCNs) with the crosslinkers, tetraethoxysilane (TEOS) and bis [(3-methyldimethoxysilyl) propyl]-polypropylene oxide (BMPPO), which also functioned as a compatibilizer. Fourier transform infrared results clearly demonstrated the occurrence of the hydrolysis reactions between the terminal hydroxyl groups on the terminal of the two polymer chains and the alkoxy groups in TEOS and BMPPO. Differential scanning calorimetry results and X-ray diffraction obviously showed the presence of the two phases in the conetworks. The contact angle (CA) indicated the wettability of the conetworks increased in the surfaces, that is, CA values decreased significantly from 105°in PDMS to 55°i n the PEG/PDMS APCN (10/1 mol ratio), and the swelling degrees of the APCNs increased from ca. 0 to 60 % when the PEG/PDMS mol ratio was larger than 4/1. The APCNs with such high hydrophilicity and the good mechanical properties should be useful as biomaterials.

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Amphiphilic conetworks: Definition, synthesis, applications

Cited by 268 publications

References 96 publications

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

Novel Biodegradable Adaptive Hydrogels: Controlled Synthesis and Full Characterization of the Amphiphilic Co‐Networks

Improved Hydrophilicity from Poly(ethylene glycol) in Amphiphilic Conetworks with Poly(dimethylsiloxane)

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