Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

Galanakou, Christina; Dhumal, Dinesh; Peng, Ling

doi:10.1039/d2bm01878k

Cited by 17 publications

(6 citation statements)

References 67 publications

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“…Due to the nanometric size with radially symmetric, mono-dispersed, and homogenous properties, dendrimers have been used in nanomedicine research. 123,124 Aside from their apparent utility as drug delivery or gene carrier systems, research has revealed that certain dendrimers have therapeutic applications of their own, primarily because of their antifungal, 125 and antibacterial, 126,127 and cytotoxic properties. 128,129 Dendrimers lie on the border between polymer and molecular chemistry.…”

Section: Redox-cleavable Star Polymersmentioning

confidence: 99%

Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications

Rahimi,

Gałęziewska,

Jerczyński

et al. 2024

Polymers for Advanced Techs

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The growing interest in functional materials has resulted in the emergence of smart polymers, demonstrating practical performance in various applications especially for biomedical purposes. The properties of functional polymers are mainly determined by the presence of functional groups that differ from those in the main chains. While some polymers are naturally active and considered functional, others require modification for enhanced impact and functionality. Many functional polymers typically have a linear backbone, but very recently the attention has been shifted towards those with specific topologies and architecture, for example, bottlebrushes, stars, dendritic polymers, and gels. Over the past few years, there has been a rising emphasis on integrating selective bonds into complex polymer structures to enhance chain scission in single macromolecules. This review captures the most recent and promising approaches to the design of non‐linear functional polymers containing selective/cleavable bonds and discusses the potential of these materials for biomedical applications.

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Section: Redox-cleavable Star Polymersmentioning

confidence: 99%

Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications

Rahimi,

Gałęziewska,

Jerczyński

et al. 2024

Polymers for Advanced Techs

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“…[208] Dendrimers can also be used to deliver antibiotics and increase the solubility of antibiotics. [209] Galanakou et al [210] systematically discussed the applications of amphiphilic dendrimers against antibiotic resistance. Due to the electrostatic interaction with anionic-charged bacterial surfaces, amphiphilic dendrimers with cationic charges can penetrate into the bacterial cell membrane, which leads to membrane destruction and then cause cell death.…”

Section: Other Applicationmentioning

confidence: 99%

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Wang,

Zhang,

et al. 2023

Small

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Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for delivering anticancer agents due to the explicit study of their characteristics of particle size, charge, and biological properties such as toxicity, blood circulation time, biodistribution, and cellular internalization. Here, the classification, preparation, and structure of dendrimer micelles are reviewed, and the specific functional groups modified on the surface of dendrimers for tumor active targeting, stimuli‐responsive drug release, reduced toxicity, and prolonged blood circulation time are discussed. In addition, their applications are summarized as various platforms for biomedical applications related to cancer therapy including drug delivery, gene transfection, nano‐contrast for imaging, and combined therapy. Other applications such as tissue engineering and biosensor are also involved. Finally, the possible challenges and perspectives of dendrimer micelles for their further applications are discussed.

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“…14,15 In the last decade, amphiphilic dendrimers, a broad series of dendrimers of asymmetric structure that includes core-shell dendrimers, Janus dendrimers, dendron-tail dendrimers as well as glycodendrimers, have attracted great attention. [16][17][18][19][20] Such structures, in addition to the inherent branched structure of dendrimers, have the ability to self-assemble to form various nanostructures, including both conventional micelles 19 and liposome-like dendrimersomes. 21 The unique chemistry of calix-and thiacalix [4]arenes, consisting of the possibility of modification of both lower and upper rims, as well as the presence of four stereoisomers, made them a convenient platform to use both as a dendrimer's core [22][23][24][25][26][27] and as dendrones.…”

Section: Introductionmentioning

confidence: 99%

Epichlorohydrin-based CuAAC dendrimers with a calix[4]arene core and polar hydroxyl/oxyethyl terminal groups: synthesis, aggregation and use in catalysis

Ocherednyuk,

Sultanova,

Makarov

et al. 2024

New J. Chem.

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Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

Abstract: The alarming and prevailing antimicrobial resistance (AMR) calls urgently for novel antibacterial agents that are effective and stable but do not induce resistance development. Amphiphilic dendrimers are emerging as a...

Cited by 17 publications

References 67 publications

Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications

Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Epichlorohydrin-based CuAAC dendrimers with a calix[4]arene core and polar hydroxyl/oxyethyl terminal groups: synthesis, aggregation and use in catalysis

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