Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes

Abstract

Newly developed an amphiphilic “turn-on” fluorescent probe (P1CS) enables to distinguish of cancer cells from normal cells through mapping of pH fluctuations in cell-surface.

A highly photostable and versatile two-photon fluorescent probe for the detection of a wide range of intracellular nitric oxide concentrations in macrophages and endothelial cells

“…The ophenylenediamine moiety reacts with NO, in the presence of oxygen, forming the electronpoor triazole derivative, DANPY-NO-T, and enhancing the fluorescence emission of the naphthalimide core. Other examples of PET-based sensors have been reported in the literature for the detection of, for example, pH [46][47][48], endogenous NADH [49] and singlet oxygen [50], among others.…”

Photoinduced electron transfer (PeT) based fluorescent probes for cellular imaging and disease therapy

“…8A). 57 In alkaline conditions, a-PeT occurs, but at acidic pH, the tertiary amine is protonated, and the a-PeT process is prevented. This results in the recovery of the 1,8-naphthalimide fluorescence intensity, as discussed above for probe 7 and probe 8 .…”

Synthesis of Naphthalimide Derivatives and Their Luminescence upon Complexation with Cucurbit[n]uril Hosts

“…Synthesis of 1. The compound 1 was synthesized according to literature procedure with same structure 23 and then obtained by anion exchange as a white solid powder (178 mg, 80%). mp > 300 °C.…”