2007
DOI: 10.1080/10717540600642431
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Amphiphilic Gels as a Potential Carrier for Topical Drug Delivery

Abstract: This study involves development of amphiphilic gels consisting solely of nonionic surfactants bearing cyclosporine and characterized for microstructure, gelation temperature, and in vitro drug release into dermis. The formulation is nonirritant and suitable for topical application. Gels consisting of cyclosporine were prepared using different methods by mixing the solid gelator (sorbitan or glyceryl fatty acid esters) and the liquid phase (liquid sorbitan esters or polysorbates) and heating them at 60• C to fo… Show more

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Cited by 15 publications
(15 citation statements)
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“…We generate the initial configuration of each new solution, which contains initiator, monomer, cross-linker, and solvent (S), by randomly placing these different beads in a box of . We equilibrate each solution for 4 10 5 simulation time steps before allowing the polymerization reaction to proceed. This process ensures that the diffusion between the current gel layer and the new solution is not influenced by the initial configuration of the solution.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…We generate the initial configuration of each new solution, which contains initiator, monomer, cross-linker, and solvent (S), by randomly placing these different beads in a box of . We equilibrate each solution for 4 10 5 simulation time steps before allowing the polymerization reaction to proceed. This process ensures that the diffusion between the current gel layer and the new solution is not influenced by the initial configuration of the solution.…”
Section: Methodsmentioning
confidence: 99%
“…Namely, the presence of both hydrophobic and hydrophilic domains enables the system to carry oil-based and waterbased components. The latter characteristics are especially important for controlled drug release applications [4,5]. Formulated as a thin film, the multi-stack gels could be applied as a dermal patch, releasing drugs through the skin.…”
Section: Introductionmentioning
confidence: 99%
“…The latter study was carried out both in vitro and in vivo , but data on therapeutic effects were absent. Amphiphilic gels made of non‐ionic surfactants can dissolve poorly water‐soluble drugs and facilitate their delivery into the skin, with surfactants acting as penetration enhancers . Amphiphilic gels composed of glyceryl monostearate (GMS) and Tween 80 were shown to promote CsA penetration into rat skin in vitro up to 40 μg/cm 2 after 12 h, while percutaneous delivery was barely detectable . Because in vivo tests showed an absence of irritancy, such gels seemed suitable for CsA delivery skin, but biological assays were not carried out. The vehicle abilities of lecithin vesicular carriers (liposomes) were studied in mice skin in vitro and in vivo .…”
Section: Introductionmentioning
confidence: 99%
“…Due to its high hydrophobicity (log p = 3.0) and low aqueous solubility (0.04 mg/ml, 25 • C) (el Tayar et al, 1993;Prasad et al, 2007), CyA cannot be formulated into the commonly aqueous formulations. Meanwhile, the intraocular penetration of CyA is very poor.…”
Section: Introductionmentioning
confidence: 98%