2014
DOI: 10.1016/j.carbpol.2013.11.003
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Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

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Cited by 73 publications
(44 citation statements)
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“…Indeed, the plot of the percentage of released DS as a function of the square root of time is basically linear for up to 5 hours (inset of figure 5). This shows that, in this time frame, drug diffusion does control the release process [40]. Afterwards, a final phase of rapid release occurs, suggesting that, at this stage of the process, a different release mechanism prevails other than ion exchange, presumably related to the partial absorption of molecules of DS inside the SMNZ that can be released only when the superficially exposed DS has been exchanged.…”
Section: In Vitro Drug Loading and Release Testsmentioning
confidence: 95%
“…Indeed, the plot of the percentage of released DS as a function of the square root of time is basically linear for up to 5 hours (inset of figure 5). This shows that, in this time frame, drug diffusion does control the release process [40]. Afterwards, a final phase of rapid release occurs, suggesting that, at this stage of the process, a different release mechanism prevails other than ion exchange, presumably related to the partial absorption of molecules of DS inside the SMNZ that can be released only when the superficially exposed DS has been exchanged.…”
Section: In Vitro Drug Loading and Release Testsmentioning
confidence: 95%
“…Hydrophobically modified HA exhibits amphiphilic characteristics in solution . The polymer backbone is hydrophilic, preferring to be associated with polar solvents through ion hydration or hydrogen bonding, while the functional groups are hydrophobic preferring to be associated with nonpolar solvents.…”
Section: Resultsmentioning
confidence: 99%
“…Similar differences can also be found among novel systems proposed as candidates for viscosupplementation. 40,[42][43][44][45] Tests performed on blends with different gel fractions have shown that an acceptable structural recovery after continuous shear application (more than 80-90 %) is attained when the gel fraction is lower than 50 %. Thus, the 6/4 CMCAp/CMCAg blend has been provisionally selected for the final investigation addressed to individuate the most suitable total polymer concentration, apt to compensate the loss in mechanical properties occurring during processing and sterilization.…”
Section: F I G 4 -Viscoelastic Responses Of 25 % Cmcap and 25 % Cmentioning
confidence: 99%