Amphiphilic-like carbon dots as antitumoral drug vehicles and phototherapeutical agents

Ortega‐Muñoz, Mariano; Vargas-Navarro, Paula; Plesselova, Simona; Girón, María D.; Iglesias, Guillermo R.; Salto, Rafael; Hernández-Matéo, Fernando; Delgado, A.V.; Lopéz-Jaramillo, Javier; Santoyo‐González, Francisco

doi:10.1039/d1qm00855b

Cited by 6 publications

(7 citation statements)

References 62 publications

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“…Supramolecular CD‐based systems for a) electron transfer, [ 182 ] b) cargo delivery, [ 180 ] c) sensing, [ 176 ] d) drug delivery of polycyclic aromatic compounds, [ 184 ] e) phototherapy, [ 185,186 ] and f) (photo)catalysis. [ 187 ] …”

Section: Overview Of Supramolecular Interactions and Their Characteri...mentioning

confidence: 99%

“…Small 2023, 19, 2300906 Figure 6. Supramolecular CD-based systems for a) electron transfer, [182] b) cargo delivery, [180] c) sensing, [176] d) drug delivery of polycyclic aromatic compounds, [184] e) phototherapy, [185,186] and f) (photo)catalysis. [187] Similar to other non-covalent interactions mentioned above, ππ stacking and hydrophobic interactions were exploited for sensing of various analytes.…”

Section: Other Non-covalent Interactionsmentioning

confidence: 99%

“…While difficult to identify these interactions, the approach of combining CDs with these hydrophobic drugs in "nanoassemblies" has shown drug delivery properties and antitumor efficacy. [186,191] To differentiate from other well-studied delivery nanosystems, the CDs-based assemblies should take advantage of nanoparticle properties for the construction of multifunctional nanotherapeutic systems. For example, the surface of CDs can be first functionalized to carry targeting ligands and peptides, and then the drugs (eg.…”

Section: Other Non-covalent Interactionsmentioning

confidence: 99%

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Supramolecular Chemistry of Carbon‐Based Dots Offers Widespread Opportunities

Arcudi

Đorđević

2023

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Carbon dots are an emerging class of nanomaterials that has recently attracted considerable attention for applications that span from biomedicine to energy. These photoluminescent carbon nanoparticles are defined by characteristic sizes of <10 nm, a carbon‐based core and various functional groups at their surface. Although the surface groups are widely used to establish non‐covalent bonds (through electrostatic interactions, coordinative bonds, and hydrogen bonds) with various other (bio)molecules and polymers, the carbonaceous core could also establish non‐covalent bonds (ππ stacking or hydrophobic interactions) with π‐extended or apolar compounds. The surface functional groups, in addition, can be modified by various post‐synthetic chemical procedures to fine‐tune the supramolecular interactions. Our contribution categorizes and analyzes the interactions that are commonly used to engineer carbon dots‐based materials and discusses how they have allowed preparation of functional assemblies and architectures used for sensing, (bio)imaging, therapeutic applications, catalysis, and devices. Using non‐covalent interactions as a bottom‐up approach to prepare carbon dots‐based assemblies and composites can exploit the unique features of supramolecular chemistry, which include adaptability, tunability, and stimuli‐responsiveness due to the dynamic nature of the non‐covalent interactions. It is expected that focusing on the various supramolecular possibilities will influence the future development of this class of nanomaterials.

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Section: Overview Of Supramolecular Interactions and Their Characteri...mentioning

confidence: 99%

Section: Other Non-covalent Interactionsmentioning

confidence: 99%

Section: Other Non-covalent Interactionsmentioning

confidence: 99%

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Supramolecular Chemistry of Carbon‐Based Dots Offers Widespread Opportunities

Arcudi

Đorđević

2023

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“…The fluorescence QY in water was calculated using as a standard the hydrosoluble sodium salts of the AA-CD obtained by treatment with NaOH and dialysis against water (QY = 0.04) [23], and applying [25]…”

Section: Fluorescence Quantum Yield (Qy) Determinationmentioning

confidence: 99%

“…In the context of nanomedicine, nanoparticles have found application [16], and carbon dots (CDs) have been recognized as therapeutic platforms [17,18], and heteroatom doping has been proven as a suitable strategy to further improve their properties [19]. Doping of CDs with Se and codoping with Se and S have been reported, and the resulting Se-doped (SeCDs) and Se-S-codoped CDs (SeSCDs) have been shown to be non-toxic, free radical scavengers and display thioredoxin reductase activity [20][21][22]. However, the chemical nature of the Se in these CDs remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

et al. 2023

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Selenium (Se) has been defined as the “Janus element”, with one face showing antioxidant activity and the other pro-oxidant activity. The biological effect of Se depends on both dose and speciation. Se nanoparticles are attracting major interest, although their large-scale preparation for biomedical applications is not trivial. We hypothesize that acid anhydride-coated carbon dots (AA-CD) are an attractive platform for preparing nanoparticles containing chemically defined Se. The reaction of AA-CD with 3-selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups (CD-SeCN) that allow for tuning the hydrosolubility. CD-SeCN has a Se content of 0.36 µmol per mg of nanoparticles, and they show the typical photoluminescence of carbon dots. The selenocyanate groups (SeCN) exhibited glutathione peroxidase-like activity and cytotoxicity. Data show that antioxidant behavior differs between normal and tumor cells, and the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose, time, and intracellular glutathione (GSH) content. The toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis, indicating that CD-SeCN is neutralized. Additionally, high levels of intracellular GSH exert a protective effect. These results support a pharmacological potential in cancers with low levels of intracellular GSH. The use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems.

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Interfacial properties, decompression, and augmented injection of amphiphilic carbon dots and surfactant mixtures

Wang,

Lu,

Wang

et al. 2023

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Amphiphilic-like carbon dots as antitumoral drug vehicles and phototherapeutical agents

Abstract: Water-insoluble carbon dots are recognized as promising materials, although their applications in nanomedicine are rarely explored, despite their lipophilic character and foreseen compatibility with biological membranes. In this article, we...

Cited by 6 publications

References 62 publications

Supramolecular Chemistry of Carbon‐Based Dots Offers Widespread Opportunities

Supramolecular Chemistry of Carbon‐Based Dots Offers Widespread Opportunities

Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

Interfacial properties, decompression, and augmented injection of amphiphilic carbon dots and surfactant mixtures

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