Amphiphilic methoxy poly(ethylene glycol)-b-poly(carbonate-selenide) with enhanced ROS responsiveness: Facile synthesis and oxidation process

Li, Siqi; Song, Fangqin; Sun, Chuanhao; Hu, Jieni; Zhang, Yan

doi:10.1016/j.eurpolymj.2021.110752

Cited by 7 publications

(5 citation statements)

References 50 publications

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“…[56] However, the excessive ROS would bring oxidative stresses, impeding the healing process. [57] Thus, various ROS-sensitive materials with responsive moieties such as sulfide, [58] selenium, [59] tellurium, [60] thioketal, [61] and aryl borate bonds [62] have been engineered to detect and scavenge the excess ROS. For instance, Sung et al [63] developed ROS-responsive ferrocene-containing copolymer-based nanofibers by electrospinning, in which the hydrophobic ferrocene tended to turn into hydrophilic Fe 3+ triggered by H 2 O 2 .…”

Section: Ros-responsive Fibersmentioning

confidence: 99%

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Dong,

Fu,

et al. 2023

Adv Funct Materials

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Smart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in wound healing and tissue reconstruction. Micro/nanofiber‐based materials are regarded as one of the most promising candidates to develop smart wound dressings owing to their remarkable features including architectural mimicry of extracellular matrix, tunability in structural assembly, and diversity in functionality. Herein, the latest progress of smart micro/nanoscale fiber‐based materials in terms of composition engineering, structural design, and applications in wound management is comprehensively reviewed. This work begins with the advances in smart fibers including stimuli‐responsive fibers, shape memory fibers, and conductive fibers. Then, the structural design of fiber‐based materials from conventional 2D fibrous membrane to emerging 3D fibrous sponge/hydrogel is thoroughly discussed. Furthermore, the applications of smart micro/nanofibrous materials as wound dressings in stimuli‐responsive drug delivery, biomechanical stimulation, electrical stimulation, and wound monitoring are highlighted. Finally, the article offers perspectives on the existing challenges and future directions of smart fibrous materials for wound management.

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Section: Ros-responsive Fibersmentioning

confidence: 99%

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Dong,

Fu,

et al. 2023

Adv Funct Materials

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“…In another novel design, a ROS-responsive polymer called mPEG45-b-poly(MSe)m was synthesized by introducing selenide groups into the polymer backbone through lipasecatalyzed ring-opening polymerization. 219 Changes in morphology, size, and turbidity were observed upon oxidation. Experimental results demonstrated that this new polymer design exhibited a more rapid and sensitive response to ROS oxidation.…”

Section: Chalcogen Ether Familymentioning

confidence: 99%

“…The researchers suggested that this nanogel holds significant potential as a polymeric nanocarrier candidate and platform for cancer treatment or ROS-sensitive drug delivery in the future. In another novel design, a ROS-responsive polymer called mPEG45- b -poly(MSe)m was synthesized by introducing selenide groups into the polymer backbone through lipase-catalyzed ring-opening polymerization . Changes in morphology, size, and turbidity were observed upon oxidation.…”

Section: Noncleavage Chemistry In Ros-responsive Materialsmentioning

confidence: 99%

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

Chi,

Sang,

Wang

et al. 2023

Bioconjugate Chem.

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The design and development of advanced drug delivery systems targeting reactive oxygen species (ROS) have gained significant interest in recent years for treating various diseases, including cancer, psychiatric diseases, cardiovascular diseases, neurological diseases, metabolic diseases, and chronic inflammations. Integrating specific chemical bonds capable of effectively responding to ROS and triggering drug release into the delivery system is crucial. In this Review, we discuss commonly used conjugation linkers (chemical bonds) and categorize them into two groups: cleavable linkers and noncleavable linkers. Our goal is to clarify their unique drug release mechanisms from a chemical perspective and provide practical organic synthesis approaches for their efficient production. We showcase numerous significant examples to demonstrate their synthesis routes and diverse applications. Ultimately, we strive to present a comprehensive overview of cleavage and noncleavage chemistry, offering insights into the development of smart drug delivery systems that respond to ROS.

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“…As ROS homeostasis in tumor tissues is imbalanced and highly susceptible to overexpression, ROS-responsive drug delivery and ROS upregulation have been discussed for enhanced cancer therapy [ 16 ]. Functional groups such as boron, chalcogen, selenium, thioether, and ferrocene are important for the development of ROS-responsive nanocarriers [ 17 , 18 ]. The H 2 O 2 -responsive drug delivery and targeted anticancer efficacy have been achieved by polymers containing thioether moieties that switch from hydrophobic to hydrophilic states via oxidation [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

ROS-responsive PEGylated ferrocene polymer nanoparticles with improved stability for tumor-selective chemotherapy and imaging

Oh,

Jeong,

Lee

et al. 2023

Materials Today Bio

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Amphiphilic methoxy poly(ethylene glycol)-b-poly(carbonate-selenide) with enhanced ROS responsiveness: Facile synthesis and oxidation process

Cited by 7 publications

References 50 publications

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

ROS-responsive PEGylated ferrocene polymer nanoparticles with improved stability for tumor-selective chemotherapy and imaging

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