Amphiphilic PEG<i>‐b‐</i>PMCL<i>‐b‐</i>PDMAEMA Triblock Copolymers: From Synthesis to Physico‐Chemistry of Self‐Assembled Structures

Matter, Yves; Enea, Ramona; Casse, Olivier; Lee, Cameron C.; Baryza, Jeremy; Meier, Wolfgang

doi:10.1002/macp.201000661

Cited by 22 publications

(30 citation statements)

References 56 publications

(100 reference statements)

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“…Lipid membranes are omnipresent in nature and serve as a role model in the design of synthetic analogues with improved stability and functionality. [30] To create polymersomes/membranes in our laboratories, we used amphiphilic block-copolymers, including (PMOXA-b-PDMS-b-PMOXA), [31] (PEG-b-PMCL), [32] (PEG-b-PMCL-b-PDMAEMA) [33] and (PB-b-PEG). [34] Initially we struggled to extend the applicable self-assembling materials to include amphiphilic peptides.…”

Section: Amphiphilic Peptides Based On a Repetitive W-l Sequencementioning

confidence: 99%

Self-assembled Structures from Amphiphilic Peptides

Sigg¹,

Schuster²,

Meier

2013

Chimia

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Nanotechnology and its applications are strongly influenced by structures self-assembled from a variety of different materials. This review covers nanostructures, including micelles, rod-like micelles, fibers and peptide beads, self-assembled from de novo designed amphiphilic peptides. The latter are promising candidates for the development of nanoscale carrier systems because they are completely composed of amino acids. In addition to designing primary sequences, secondary structure and external parameters are also discussed with respect to their impact on self-assembly. Moreover, the assembly process itself is examined. Potential applications range from gene and drug delivery devices to diagnostics, thereby highlighting the versatility of the system.

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Section: Amphiphilic Peptides Based On a Repetitive W-l Sequencementioning

confidence: 99%

Self-assembled Structures from Amphiphilic Peptides

Sigg¹,

Schuster²,

Meier

2013

Chimia

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“…Adapted from ref. (Reproduced with permission from John Wiley and Sons Publishing Group . Copyright (2011)).…”

Section: Synthesis Of Abc Triblock Copolymersmentioning

confidence: 99%

“…In addition, ABC polymers with two phase separating core‐forming blocks can self‐assemble into multicompartment ( i.e ., containing domains in the core) structures . Another advantage of ABC polymers is that different stimuli responsive blocks can be combined into one polymer …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Linear ABC Triblock Copolymers and Their Self‐Assembly in Solution

Konishcheva

Daubian

Gaitzsch

et al. 2018

Helvetica Chimica Acta

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The self‐assembly of amphiphilic block copolymers has attracted the interest of a large number of research groups in the past two decades. Many examples have been reported using AB diblock copolymers, but the self‐assembly becomes more complex and shows a greater variety if ABC triblock copolymers are used. However, the synthesis of the polymer becomes more demanding since end‐group modifications or chain extensions become necessary. Using various kinds of polymerization techniques, pure triblock copolymers have been reported and their synthesis is covered in this review. Following the synthesis, a detailed and thorough analysis of the self‐assembly behaviour is the next step. We have selected promising and well characterized examples to show the range of self‐assembled structures possible, covering novel shapes of micelles but also polymersomes with an asymmetric membrane. Our selection of current examples in literature show the challenges and chances associated with amphiphilic ABC triblock copolymers.

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“…Literature values for each constituent homopolymer were used for the RI contributions; 0.135, 0.12 and 0.03 mL g À1 for PEO, PMCL and PFPO respectively. [113][114][115] The insolubility of PFPO in THF prohibits determination of a dn/dc value for this polymer in this solvent. However, the low dn/dc value estimate (since all perfluoroethers have low dn/dc values in a range of solvents) and the small fraction of PFPO within the m-O(CF) n terpolymers (#0.26) means that the calculated dn/dc values/M n by MALS for the terpolymers is insignificantly affected by the value for PFPO.…”

Section: Synthesis Of M-o(cf) N Terpolymersmentioning

confidence: 99%

Synthesis of block polymer miktobrushes

et al. 2013

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Well defined m-A(BC) n 'miktobrush' terpolymers were synthesized utilizing the alternating radical copolymerization of two hydrophobic and incompatible macromonomer (MM) building blocks; a maleimide (MI) end functionalized poly(methyl-caprolactone) block (MI-PMCL) or 'C' and a styrene (Sty) end functionalized poly(perfluoro propylene oxide) block (Sty-PFPO) or 'F'. Polymerizations were mediated by a poly(ethylene oxide) (PEO) functionalized reversible addition-fragmentation chain transfer (RAFT) agent (PEO-CTA) or 'O' to control the chain growth of the MMs from the O block to form O(CF) n ''miktobrush'' terpolymers. The synthesis of a range of well defined m-O(CF) n terpolymers with various compositions was achieved by changing the feed of MMs. All building blocks and brush polymers were characterized by nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC) and elemental analyses. This new strategy offers a powerful route towards a block polymer architecture that can enable the formation of multi-domain hierarchical nanostructures with features on multiple length scales due to the incompatibility and unique connectivity of the building blocks incorporated.Block polymers can spontaneously self-assemble into welldefined nanostructures in block selective solvents and in the bulk, offering a powerful 'bottom up' approach towards precisely engineered materials for many diverse applications including; microelectronics, 1 tissue engineering, 2 drug delivery and water purification. 3 The increased understanding of self-assembled block polymers with varied architectures is of both fundamental and technological importance. 4 Towards this goal, AB diblock copolymers have been studied in depth. 5-7 Adding more blocks and functional groups to AB diblock copolymers increases architectural and functional complexity and can lead to more exotic self-assembled morphologies. 8,9 For instance, in a solvent selective for the A block, an ABC triblock terpolymer will form 'multicompartment micelles' whereby the two solvophobic (and incompatible) B and C blocks will produce two separate nanoscopic core domains. 10,11 If the chemistry of the microphase separated domains (B and C) is sufficiently different, multicompartment micelles can facilitate the storage of distinct small molecules within their separate core domains, thus enabling simultaneous storage and delivery of multiple incompatible payloads. 12 Linear ABC terpolymers, 13-19 linear BAC or ACB terpolymers, 20 side chain grafted ABC terpolymers or 'polysoaps', 21-23 miktoarm star m-ABC terpolymers, 24-30 and blends of block polymers 31-36 have been pursued as multicompartment micelle systems by various research groups. In each case, the connection point of the solvophobic B and C chains relative to the solvophilic corona forming block, A influences the micelle morphology to a great extent, although factors such as the solvophobicity and overall terpolymer composition play important roles. 5,11 In m-ABC terpolymers, three mutually immiscible blocks are...

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Amphiphilic PEG‐b‐PMCL‐b‐PDMAEMA Triblock Copolymers: From Synthesis to Physico‐Chemistry of Self‐Assembled Structures

Cited by 22 publications

References 56 publications

Self-assembled Structures from Amphiphilic Peptides

Self-assembled Structures from Amphiphilic Peptides

Synthesis of Linear ABC Triblock Copolymers and Their Self‐Assembly in Solution

Synthesis of block polymer miktobrushes

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