Amphiphilic phosphorous dendron micelles co-deliver microRNA inhibitor and doxorubicin for augmented triple negative breast cancer therapy

Abstract

Combined chemo/gene therapy of cancer through different action mechanisms has been emerging to enhance the therapeutic efficacy of cancer, and still remains to be a challenging task due to the...

Bioactive Phosphorus Dendrimers as a Universal Protein Delivery System for Enhanced Anti-inflammation Therapy

“…Different nanoplatforms based on phosphorus dendrimers have been created as carriers for the delivery of genes or drugs due to their biological activities. − The interaction of cationic phosphorus dendrimers with proteins has been described, while the necessity of depending on positive charge to deliver protein intracellularly needs to be reevaluated given that high densities of positive charge cause unpredictable cytotoxicity . Therefore, it is vital to develop efficient carriers based on anionic phosphorus dendrimers to effectively deliver functional proteins to exert synergistic and enhanced therapeutic effects.…”

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

“…Phosphorus dendrimers or dendrons, due to their good biocompatibility and the presence of a large number of modifiable sites on the surface and branches, have been shown to have excellent performance in drug delivery, , gene transfection ,− and drug active per se . − Their relatively convenient synthesis method also allows the development of various nanoparticulate systems to tackle a wide range of diseases. Our earlier work has shown that phosphorus dendrimers bearing pyrrolidinium or piperidinium on their surface can be used for gene delivery to treat breast cancer .…”