2010
DOI: 10.1155/2010/423460
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Amphiphilic Poly(3-hydroxy alkanoate)s: Potential Candidates for Medical Applications

Abstract: Poly(3-hydroxy alkanoate)s, PHAs, have been very attractive as biomaterials due to their biodegradability and biocompatibility. These hydrophobic natural polyesters, PHAs, need to have hydrophilic character particularly for drug delivery systems. In this manner, poly(ethylene glycol) (PEG) and hydrophilic functional groups such as amine, hydroxyl, carboxyl, and sulfonic acid have been introduced into the PHAs in order to obtain amphiphilic polymers. This review involves in the synthesis and characterization of… Show more

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Cited by 64 publications
(17 citation statements)
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“…[135][136][137][138][139][140][141] Such modifications for the pedant groups make these mcl-PHAs functional with unusual physicochemical and mechanical properties. 142,143 Chlorination switched mcl-PHAs from sticky to hard, brittle and crystalline, depending on chlorine contents. 126 Crosslinking by gamma irradiation made these mcl-PHAs with higher tensile strength.…”
Section: Biosynthesis and Modification Of Mcl-phas From Glycerolmentioning
confidence: 99%
“…[135][136][137][138][139][140][141] Such modifications for the pedant groups make these mcl-PHAs functional with unusual physicochemical and mechanical properties. 142,143 Chlorination switched mcl-PHAs from sticky to hard, brittle and crystalline, depending on chlorine contents. 126 Crosslinking by gamma irradiation made these mcl-PHAs with higher tensile strength.…”
Section: Biosynthesis and Modification Of Mcl-phas From Glycerolmentioning
confidence: 99%
“…Indeed, the choice of the hydrophobic block strongly impacts the physico-chemical properties of the resulting self-assembled systems such as the hydrodynamic radius and the critical micelle concentration (CMC) which are two key parameters. Poly(hydroxyalkanoates) (PHAs) and poly(carbonates) (PCs) have attracted considerable attention for the design of drug delivery systems due to their high biocompatibility and low toxicity (Furrer et al, 2008;Wu et al, 2009;Hazer, 2010;Hu et al, 2012;Shrivastav et al, 2013;Chen et al, 2014;Loyer and Cammas-Marion, 2014;Li and Loh, 2015;Nigmatullin et al, 2015). In this context, poly(3-hydroxybutyrate) and poly(trimethylene carbonate) have been developed to produce gels and matrices for tissue engineering (Shishatskaya et al, 2004 ;Asran et al, 2010 ;Song et al, 2011 ;Schüller-Ravoo et al, 2013 ;Rozila et al, 2016 ;Ding et al, 2016 ;Pascu et al, 2016 ;Zant et al, 2016) and NPs for drug delivery (Xiong et al, 2010 ;Jiang et al, 2013 ;Fukushima 2016 ;Pramual et al, 2016).…”
mentioning
confidence: 99%
“…In our previous study, we have already shown that PP-g-PEG patches have good soft tissue response, and the biocompatibility of the polymer is increased as more of a PEG side chain is added [14]. Many studies have reported that hydrophilic surfaces, such as PEGgrafted polymers, suppress protein adsorption and platelet adhesion [12,18,45]. These surface characteristics help this graft copolymer to reduce protein deposition that promotes pathogen adhesion and growth on device surfaces [31,35,36].…”
Section: Groups-catheter: Interaction Between Groups and Catheter Facmentioning
confidence: 97%