Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies

Pontes-Quero, Gloria María; Benito-Garzón, Lorena; Cano, Juan Pérez; Aguilar, María Rosa; Vázquez‐Lasa, Blanca

doi:10.1016/j.msec.2020.111793

Cited by 53 publications

(31 citation statements)

References 78 publications

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“…The antioxidant activity of curcumin is attributed to its unique conjugated structure, which shows typical radical-trapping ability as a chain-breaking antioxidant [ 55 ]. Numerous studies reported enhanced antioxidant properties of the curcumin encapsulated in colloidal system such as liposomes [ 56 ], polymeric microparticles [ 57 ], hydrogel beads [ 58 ], nanoparticles [ 59 ], and microemulsions [ 60 ]. Curcumin containing microemulsion and microemulsion gel was developed with grape seed oil as a lipid phase, where the synergistic antioxidant activity of the optimized microemulsion and gel microemulsions was observed due to the presence of grape seed oil which helped effectively encapsulate and preserve the antioxidant stability of curcumin [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Curcumin-Encapsulated α-Tocopherol Nanoemulsion System and Its Potential Application for Wound Healing in Diabetic Animals

Ali

Khan

Subhan

et al. 2022

BioMed Research International

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Objective This project was aimed at formulating a novel nanoemulsion system and evaluating it for open incision wound healing in diabetic animals. Methods The nanoemulsions were characterized for droplet size and surface charge, drug content, antioxidant and antimicrobial profiling, and wound healing potential in diabetic animals. The skin samples excised were also analyzed for histology, mechanical strength, and vibrational and thermal analysis. Results The optimized nanoemulsion (CR-NE-II) exhibited droplet size of26.76 ± 0.9 nm with negative surface charge (−10.86 ± 1.06 mV), was homogenously dispersed with drug content of68.05 ± 1.2%, released almost82.95 ± 2.2%of the drug within first 2 h of experiment with synergistic antioxidant (95 ± 2.1%) and synergistic antimicrobial activity against selected bacterial strains in comparison to blank nanoemulsion, and promoted significantly fast percent reepithelization (96.47%). The histological, vibrational, thermal, and strength analysis of selected skin samples depicted a uniform and even distribution of collagen fibers which translated into significant increase in strength of skin samples in comparison to the control group. Conclusions The optimized nanoemulsion system significantly downregulated the oxidative stress, enhanced collagen deposition, and precluded bacterial contamination of wound, thus accelerating the skin tissue regeneration process.

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Section: Resultsmentioning

confidence: 99%

Novel Curcumin-Encapsulated α-Tocopherol Nanoemulsion System and Its Potential Application for Wound Healing in Diabetic Animals

Ali

Khan

Subhan

et al. 2022

BioMed Research International

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“…many kinds of carriers and preparation methods of curcumin nanometer preparations, and they are often modified to obtain the desired properties. 176,177 For example, using hyaluronic acid to modify the surface of curcumin nanoparticles can maintain a high level of curcumin in the colon tissue, reduce the proinflammatory factors and reduce the inflammatory response in the colon, which is conducive to the treatment of ulcerative colitis. 178,179 In some inflammatory diseases with superficial disease sites, such as psoriasis and arthritis, nano-emulsion and nanogel can enhance the penetration and accumulation of curcumin in the skin through local administration, which can be used as a direction of preparation research.…”

Section: Pharmaceutical Strategiesmentioning

confidence: 99%

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Peng¹,

Ao²,

BaoHua³

et al. 2021

DDDT

358

157

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“…Vitamin C, Vitamin E, Curcumin, Selenium [37,106,108,109] Antiviral Selenium, Curcumin, Quercetin, Riboflavin, Vitamin C, Green Tea, Propolis, Resveratrol, Zinc [99,100,103,109,110,111,112,113] Immune response Vitamin A, Vitamin C, Vitamin D, Vitamin B12, Folate, Pyridoxine, Zinc, Nicotinamide, Selenium [38,109,113] Interferon production Vitamin C [111] Virus-ACE2 interaction reduction Quercetin, Curcumin [11]…”

Section: Antioxidantmentioning

confidence: 99%

A review of natural foods consumed during the COVID-19 pandemic life

Hurcan

İrkin

2022

Postępy Higieny I Medycyny Doświadczalnej

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Coronavirus 2019 (COVID-19) is an infectious disease that has brought life to a standstill around the world. Until a vaccine was found to combat COVID-19, the world conducted research and made recommendations for nutritional natural foods. Considering the risks incurred by contracting the disease, even though the production of various vaccines and vaccination of healthy people has started in some countries, individuals need useful foods to be ready for the COVID-19 pandemic. Recently, nutrient contents such as antioxidant compounds, vitamins, minerals, and probiotics that contribute to the immune system have been investigated. This paper attempts to determine the role of these dietary supplements in reducing the risk of COVID-19 and/or changing the course of the disease in COVID-19 patients and their effects on mortality. Supplements used and recommended for the COVID-19 pandemic life were investigated. In conclusion, more research is needed to determine the effectiveness of nutrients, vitamins, minerals, probiotics, prebiotics, and antioxidants used during the COVID-19 pandemic to inhibit the effect of SARS-CoV-2. In order to overcome the new global crisis, nutritional cures and treatments should be upgraded. However, additional research on the subject is needed.

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Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies

Cited by 53 publications

References 78 publications

Novel Curcumin-Encapsulated α-Tocopherol Nanoemulsion System and Its Potential Application for Wound Healing in Diabetic Animals

Novel Curcumin-Encapsulated α-Tocopherol Nanoemulsion System and Its Potential Application for Wound Healing in Diabetic Animals

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

A review of natural foods consumed during the COVID-19 pandemic life

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