Amphiphilic quaternized chitosan: Synthesis, characterization, and anti-cariogenic biofilm property

Phuangkaew, Tinnakorn; Booranabunyat, Nadda; Kiatkamjornwong, Suda; Thanyasrisung, Panida; Hoven, Voravee P.

doi:10.1016/j.carbpol.2021.118882

Cited by 42 publications

(20 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When Cl − was completely converted into AgCl, conductivity (k) reached its minimum. Then, with the addition of excessive AgNO 3 , conductivity (k) improved with the increase of Ag + and NO3 − , which is consistent with previous reports [ 32 ]. The curve shown in Figure 8 was plotted with the conductivity (k) as the ordinate and the volume (V) of AgNO 3 as the abscissa.…”

Section: Resultssupporting

confidence: 92%

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Liu

et al. 2021

Polymers

View full text Add to dashboard Cite

Herein, a novel chitosan derivative nanoparticle was proposed to function as a delivery carrier. First of all, an improvement was made to the way N-2-hydroxypropyl trimcthyl ammonium chloride chitosan (N-2-HACC) was synthesized. Moreover, the solution to one-step synthesis of N-2-HACC from chitosan (CS) was developed. Different from the previous report, the synthesis process was simplified, and there was a reduction in the amount of 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) used. With its excellent water solubility maintained, the relatively low degree of substitution was controlled to facilitate the cross-linking reaction. The results obtained from 1H-NMR, FTIR spectroscopy, and XRD indicated a smooth EPTAC onto CS for the formation of N-2-HACC with 59.33% the degree of substitution (DS). According to our results, N-2-HACC could be dissolved in various organic solvents, deionized water, 1% acetic acid aqueous solution, and others at room temperature. Finally, a novel chitosan nanoparticle material was prepared using the self-assembly method with β-glycerophosphate sodium (β-GC), with excellent immune properties achieved, thus providing a new strategy for chitosan self-assembled nanoparticles.

show abstract

Section: Resultssupporting

confidence: 92%

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Liu

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…Additionally, curcumin, as well as chitosan and its derivatives, has been shown to have broad-spectrum antibacterial properties. Moreover, QCS shows superior water solubility and antibacterial activity compared with chitosan …”

Section: Resultsmentioning

confidence: 99%

Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing

Huang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The surface structure and topography of biomaterials play a crucial role in directing cell behaviors and fates. Meanwhile, asymmetric dressings that mimic the natural skin structure have been identified as an effective strategy for enhancing wound healing. Inspired by the skin structure and the superhydrophobic structure of the lotus leaf, an asymmetric composite dressing was obtained by constructing an asymmetric structure and wettability surface modification on both sides of the sponge based on electrospinning. Among them, the collagen and quaternized chitosan sponge was fabricated by freeze-drying, followed by an aligned poly(ε-caprolactone) (PCL)/gelatin nanofiber hydrophilic inner layer and hierarchical micronanostructure PCL/polystyrene microsphere highly hydrophobic outer layer constructed on each side of the sponge. The proposed asymmetric composite dressing combines topological morphology with the material’s properties to effectively prevent bacterial colonization/infection and promote wound healing by directing cellular behavior. In vitro experimental results confirmed that the aligned nanofiber inner layer effectively promotes cell adhesion, proliferation, directed cell growth, and migration. Meanwhile, the sponge has good water absorption and antibacterial properties, while the biomimetic hydrophobic outer layer exhibits strong mechanical properties and resistance to bacterial adhesion. In vivo results showed that the composite dressing can reduce inflammatory response, prevent infection, accelerate angiogenesis and epithelial regeneration, and significantly accelerate the healing of severe burns. Thus, the proposed bionic asymmetric dressing is expected to be a promising candidate for severe burn wound healing.

show abstract

“…Similar to QAS, the length of hydrophobic groups can also influence the antibacterial activity. Phuangkaew et al introduced hydrophobic entities and quaternary ammonium groups to improve the antibacterial capability (Phuangkaew et al, 2022).…”

Section: Polymersmentioning

confidence: 99%

“…Phuangkaew et al. introduced hydrophobic entities and quaternary ammonium groups to improve the antibacterial capability ( Phuangkaew et al., 2022 ).…”

Section: Materials Strategiesmentioning

confidence: 99%

Dental Materials for Oral Microbiota Dysbiosis: An Update

Zhu

Chu

Luo

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The balance or dysbiosis of the microbial community is a major factor in maintaining human health or causing disease. The unique microenvironment of the oral cavity provides optimal conditions for colonization and proliferation of microbiota, regulated through complex biological signaling systems and interactions with the host. Once the oral microbiota is out of balance, microorganisms produce virulence factors and metabolites, which will cause dental caries, periodontal disease, etc. Microbial metabolism and host immune response change the local microenvironment in turn and further promote the excessive proliferation of dominant microbes in dysbiosis. As the product of interdisciplinary development of materials science, stomatology, and biomedical engineering, oral biomaterials are playing an increasingly important role in regulating the balance of the oral microbiome and treating oral diseases. In this perspective, we discuss the mechanisms underlying the pathogenesis of oral microbiota dysbiosis and introduce emerging materials focusing on oral microbiota dysbiosis in recent years, including inorganic materials, organic materials, and some biomolecules. In addition, the limitations of the current study and possible research trends are also summarized. It is hoped that this review can provide reference and enlightenment for subsequent research on effective treatment strategies for diseases related to oral microbiota dysbiosis.

show abstract

Amphiphilic quaternized chitosan: Synthesis, characterization, and anti-cariogenic biofilm property

Cited by 42 publications

References 38 publications

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing

Dental Materials for Oral Microbiota Dysbiosis: An Update

Contact Info

Product

Resources

About