Amphiphilic xylan–cholic acid conjugates: synthesis and self-assembly behaviors in aqueous solution

Design and synthesis of triphenylphosphonium-porphyrin@xylan nanoparticles for anticancer photodynamic therapy

“…SiNPS are subject to controversy due to their potential negative impact on human health [28]; this is why we decided to create nanoparticles without the silica core. It has recently been reported that conjugates consisting of hydrophilic xylan backbone and hydrophobic segments can form self-assembled nanoparticles in aqueous solution [29][30][31][32][33]. As a first step, we evaluated the self-assembly of different conjugates of xylan and 5-(4-hydroxyphenyl)-10,15,20triphenylporphyrin with DS varying from 0.3 to 1.1.…”

Acetylxylan‐pheophorbide‐a nanoparticles designed for tumor‐targeted photodynamic therapy

“…The antimigration and antiproliferative effects of chestnut xylan have been explained, in part, by a decrease in the expression of metalloproteinases MMP9 and MMP2 14 . Recently, xylan‐based nanoparticles loaded with anticancer agents have been widely studied 15,16,17,18,19 . However, the conjugation of PS with xylan for use in targeted PDT are somewhat limited 20,21 …”

“…14 Recently, xylan-based nanoparticles loaded with anticancer agents have been widely studied. 15,16,17,18,19 However, the conjugation of PS with xylan for use in targeted PDT are somewhat limited. 20,21 Herein, we report the extraction of xylan from chestnut sawdust, and the hemisynthesis of pheophorbide-a from the cyanobacterium Spirulina maxima, followed by the synthesis and characterization of a xylan-Pha conjugate.…”