Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus

Dotis, John; Simitsopoulou, Maria; Dalakiouridou, Maria; Konstantinou, T.; Panteliadis, Christos P.; Walsh, Thomas J.; Roilides, Emmanuel

doi:10.1093/jac/dkn036

Cited by 26 publications

(17 citation statements)

References 33 publications

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“…L-AmB exhibits additive activity with host phagocytic cells against a variety of medically important filamentous fungi [13,20,[85][86][87]. Unlike AmB-D, this positive interaction is more pronounced in conjunction with neutrophils than with macrophages.…”

Section: Lipid Formulations Of Amb: Immunomodulation By the Lipid Carmentioning

confidence: 96%

Immunocompromised Hosts: Immunopharmacology of Modern Antifungals

2008

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In addition to their in vitro inhibitory and fungicidal effects, modern antifungal agents interact in vivo with host immune functions involved in defense against fungal pathogens. The nature of such interactions is diverse and depends on the drug, the immunological status of the host, and the fungal pathogen. Given the prominent role of the host's immune response in controlling invasive fungal infection, immunomodulation by antifungal drugs may prove to be clinically significant. Elucidation of the immunopharmacology of these drugs may aid in designing therapeutic regimens for specific clinical scenarios associated with defined immunological dysfunction.

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Section: Lipid Formulations Of Amb: Immunomodulation By the Lipid Carmentioning

confidence: 96%

Immunocompromised Hosts: Immunopharmacology of Modern Antifungals

2008

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“…The results of preclinical studies support the use of immunotherapeutic agents in fusariosis management. Ex vivo studies have shown that amphotericin B (deoxycholate and lipid formulations) at clinically relevant concentrations enhance the antifungal activity of human phagocytes against F. solani [118]. Similar ex vivo studies have demonstrated that IL-15 plays an important role in the immunomodulation of host responses against Fusarium spp.…”

Section: Scedosporiosismentioning

confidence: 84%

Immunotherapy against Invasive Mold Infections

Antachopoulos

Katragkou

Roilides³

2011

Immunotherapy

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Invasive infections due to filamentous fungi, such as Aspergillus spp., Zygomycetes, Scedosporium and Fusarium spp., cause significant morbidity and mortality in immunocompromised patients with hematological malignancies, recipients of hematopoietic stem cell transplants and those with chronic granulomatous disease. Despite antifungal therapy, the outcome is often unfavorable in these patients; immune restoration is considered as the cornerstone of successful treatment. Important aspects of human immune response against fungi include effective innate immune response expressed as effective phagocytic functions and a balance between proinflammatory and regulatory adaptive immune responses. A number of immunomodulatory approaches, including the administration of enhancing cytokines, adoptive transfer of pathogen-specific T lymphocytes and granulocyte transfusions have been investigated as adjunctive treatments against serious mold infections. Despite encouraging in vitro and in vivo data, current clinical evidence is not sufficient to allow firm recommendations on the use of these immunomodulatory modalities in serious mold infections.

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“…Although the use of immunotherapeutic agents is not established in fusariosis management, there are preclinical data supporting their utility. Amphotericin B formulations (deoxycholate and lipid formulations) at clinically relevant concentrations have been shown in ex vivo studies to have immunomodulatory effects on human neutrophils and monocytes [68] and on rabbit pulmonary macrophages [69] in response to F. solani . Similar ex vivo studies have demonstrated that interleukin (IL)‐15 plays an important role in the immunomodulation of host responses against Fusarium spp.…”

Section: Fusariosismentioning

confidence: 99%

Immunotherapy of infections caused by rare filamentous fungi

Katragkou

Roilides

2012

Clinical Microbiology and Infection

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Invasive fungal infections caused by rare filamentous fungi constitute a significant cause of morbidity and mortality in patients with defective immune responses. Despite the advent of new antifungal agents, the problem is escalating as the number of susceptible hosts increases and virulent, more resistant fungal strains emerge. There is evidence that reconstitution of the host immune function is a major contributor to the resolution of these infections. Therapeutic modalities aimed at increasing phagocyte numbers, such as granulocyte transfusions, stimulating the immune response, such as administration of haematopoietic growth factors and other proinflammatory cytokines, or indirectly augmenting immune function have shown promising results in the preclinical setting. Because of the rarity of the infections, multicentre clinical trials are needed to demonstrate the efficacy and safety of the new immunomodulating approaches.

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Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus

Cited by 26 publications

References 33 publications

Immunocompromised Hosts: Immunopharmacology of Modern Antifungals

Immunocompromised Hosts: Immunopharmacology of Modern Antifungals

Immunotherapy against Invasive Mold Infections

Immunotherapy of infections caused by rare filamentous fungi

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