AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from <i>Siraitia grosvenorii</i> (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice

Liu, Hesheng; Xiang-yang, QI; Yu, Kejing; Lu, Anjie; Lin, Kaifeng; Zhu, Jiajing; Zhang, Min; Sun, Zhida

doi:10.1039/c8fo01486h

Cited by 64 publications

(49 citation statements)

References 52 publications

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“…Currently, MFE is used mainly for its antitussive, expectorant, antidiabetic, or sweet properties in Chinese herbal products and dietary supplements (Li et al, 2014). Oral administration of mogroside V in the treatment of STZ-induced diabetes mellitus mice has been studied (Qi et al, 2008;Liu et al, 2019). Mogroside V was used to prevent and treat diabetes mellitus, but the effect of foods fortified with MFE on type 2 diabetes has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Monk fruit extract (MFE) has been used as a non-nutritive sweetener and flavor enhancer in the United States, China, and Japan, and it is a safe and suitable low-calorie sweetener for people with type 2 diabetes (Qi et al, 2008;Zhou et al, 2009;Xu et al, 2015;Zhou et al, 2018). It also has promising pharmacological functions related to reducing blood glucose (Qi et al, 2006;Zhou et al, 2009;Shi et al, 2014;Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Effects of a synbiotic yogurt using monk fruit extract as sweetener on glucose regulation and gut microbiota in rats with type 2 diabetes mellitus

Ban

Cheng

Sun

et al. 2020

Journal of Dairy Science

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We developed a synbiotic yogurt using monk fruit extract as a sweetener and investigated the effects of feeding the yogurt to rats with type 2 diabetes induced by streptozotocin and a high-fat diet. The rats fed the synbiotic yogurt showed greater blood glucose regulation and a significant decrease in insulin resistance and glycosylated hemoglobin compared with rats fed yogurt sweetened with sucrose, and they showed a remarkable improvement in short-chain fatty acid levels and gut microbiota status. Liver and kidney damage was also ameliorated in the rats fed the synbiotic yogurt. Immunohistochemistry analysis showed that the synbiotic yogurt inhibited β-cell loss compared with the control yogurt. Consuming the synbiotic yogurt helped to restore the islets of Langerhans. Our results indicated that monk fruit extract may be a good alternative to sucrose for synbiotic yogurt products in people with type 2 diabetes to delay the progression of diabetes and associated complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of a synbiotic yogurt using monk fruit extract as sweetener on glucose regulation and gut microbiota in rats with type 2 diabetes mellitus

Ban

Cheng

Sun

et al. 2020

Journal of Dairy Science

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show abstract

“…T2DM is a chronic metabolic disorder syndrome characterized by hyperglycemia and dyslipidemia [29]. T2DM afflicts about 383 million adults, emerging as a serious health burden [30,31].…”

Section: Discussionmentioning

confidence: 99%

Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus

Wang

Liang

et al. 2019

IJMS

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Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction which can be induced by oxidative stress. Deuterohemin-βAla-His-Thr-Val-Glu-Lys (DhHP-6) is a microperoxidase mimetic that can scavenge reactive oxygen species (ROS) in vivo. In our previous studies, we demonstrated an increased stability of linear peptides upon their covalent attachment to porphyrins. In this study, we assessed the utility of DhHP-6 as an oral anti-diabetic drug in vitro and in vivo. DhHP-6 showed high resistance to proteolytic degradation in vitro and in vivo. The degraded DhHP-6 product in gastrointestinal (GI) fluid retained the enzymatic activity of DhHP-6, but displayed a higher permeability coefficient. DhHP-6 protected against the cell damage induced by H2O2 and promoted insulin secretion in INS-1 cells. In the T2DM model, DhHP-6 reduced blood glucose levels and facilitated the recovery of blood lipid disorders. DhHP-6 also mitigated both insulin resistance and glucose tolerance. Most importantly, DhHP-6 promoted the recovery of damaged pancreas islets. These findings suggest that DhHP-6 in physiological environments has high stability against enzymatic degradation and maintains enzymatic activity. As DhHP-6 lowered the fasting blood glucose levels of T2DM mice, it thus represents a promising candidate for oral administration and clinical therapy.

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“…The paraffin-embedded tissue sections were routinely stained with HE staining to conduct histologic analysis [25] . [26,27] . Primary antibodies against GLUT4 (1:1000 Detection System (Applied Biosystems).…”

Section: He Stainingmentioning

confidence: 99%

Tertiary Butylhydroquinone Ameliorates Insulin Resistance and Liver Steatosis in Type 2 Diabetes Mellitus

Zhu

Liu

et al. 2020

Preprint

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Aims: This study aimed to evaluate the effects and mechanisms of tertiary butylhydroquinone (TBHQ) on insulin resistance (IR) and diabetic liver steatosis. Methods: Male ApoE-/- mice were received streptozocin (STZ) injection and a high-sugar-high-fat diet to form type 2 diabetes mellitus (T2DM). Then, the mice were given TBHQ for six weeks. Body weight, fasting blood-glucose (FBG), postprandial blood glucose (PBG), insulin and oral glucose tolerance test (OGTT) were detected on all the mice. Hematoxylin-eosin staining and western-blot were performed to detect the morphological structure and the target proteins expression in liver tissues. In vitro, HepG2 cells were induced by HClO and insulin to develop IR. Western-blot was used to evaluate the related proteins expression. Hoechst staining was conducted to measure cell apoptosis. Results: Mice that received STZ injection and a high-sugar-high-fat diet developed T2DM. TBHQ reduced blood glucose level, improved glucose tolerance, alleviated liver steatosis in diabetic mice. Moreover, TBHQ significantly increased AMPKα2, GLUT4 and GSK3β expression, up-regulated PI3K and AKT phosphorylation level in diabetic mice liver. Notably, TBHQ down-regulated HClO and insulin-induced cell IR and inhibited cell apoptosis via AMPKα2/PI3K/AKT pathway. Conclusion: TBHQ alleviated IR and liver steatosis in T2DM mice and the mechanism may relate to AMPKα2/PI3K/AKT pathway.

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AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice

Abstract: AMPK is involved in hypoglycemic and hypolipidemic activities of mogrosides from Siraitia grosvenorii (Swingle) fruits on diabetic mice.

Cited by 64 publications

References 52 publications

Effects of a synbiotic yogurt using monk fruit extract as sweetener on glucose regulation and gut microbiota in rats with type 2 diabetes mellitus

Effects of a synbiotic yogurt using monk fruit extract as sweetener on glucose regulation and gut microbiota in rats with type 2 diabetes mellitus

Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus

Tertiary Butylhydroquinone Ameliorates Insulin Resistance and Liver Steatosis in Type 2 Diabetes Mellitus

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