AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity

Lee, Joo Won; Choe, Sung Sik; Jang, Hyejeong; Kim, Jiyeong; Jeong, Hyun Woo; Jo, Hyunsun; Jeong, Kyeong Hoon; Tadi, Surendar; Park, Myoung Gyu; Kwak, Tae Hwan; Kim, Jin Man; Hyun, Dong Hoon; Kim, Jae Bum

doi:10.1194/jlr.m022897

Cited by 88 publications

(59 citation statements)

References 60 publications

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“…Unhealthy lifestyle factor such as smoking [12], alcohol drinking [13,14], sedentary lifestyle [15], overweight and obesity [16,17] are risk factors of hypercholesterolemia. Consistent with other studies, health-related behavioral factors, such as drinking was substantially associated with hypercholesterolemia in our study.…”

Section: Discussionmentioning

confidence: 99%

Trends in Determinants of Hypercholesterolemia among Chinese Adults between 2002 and 2012: Results from the National Nutrition Survey

Song

Man

et al. 2017

Nutrients

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Hypercholesterolemia is a known risk factor for cardiovascular diseases and affects a high proportion of the population. This study aimed to assess and compare the determinants of hypercholesterolemia among Chinese adults aged 18 years and above, from 2002 to 2012. The study used a stratified multistage cluster sampling method to select participants. Sociodemographic and lifestyle information was collected during face-to-face interviews. Dietary intake was calculated by 3-day, 24-h dietary records in combination with weighted edible oil and condiments. Hypercholesterolemia was defined as total cholesterol above 6.22 mmol/L (240 mg/dL) from fasting blood samples. The study included 47,701 (mean age 43.0 years) and 39,870 (mean age 51.0 years) participants in 2002 and 2010–2012 surveys respectively. The weighted prevalence of hypercholesterolemia increased from 1.6% (2.1% urban, 1.0% rural) in 2002 to 6.0% (6.4% urban, 5.1% rural) in 2012. The intake of plant-based food decreased but the intake of pork increased over the 10 years. A high intake of protein and pork, alcohol drinking and overweight/obesity were positively associated with hypercholesterolemia. Neither education nor fruit and vegetable intake were associated with hypercholesterolemia. In conclusion, the burden of hypercholesterolemia increased substantially between 2002 and 2012 in China. Unhealthy lifestyle factors and change in traditional dietary pattern were positively associated with hypercholesterolemia. Further research on the role of diet in the development and prevention of hypercholesterolemia is needed.

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Section: Discussionmentioning

confidence: 99%

Trends in Determinants of Hypercholesterolemia among Chinese Adults between 2002 and 2012: Results from the National Nutrition Survey

Song

Man

et al. 2017

Nutrients

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“…Lee et al have studied the direct effect of Glab on AMPK activity in obese rodents models (C57BL/6J mice)[107]. They observed that Glab decreases adiposity and ameliorates lipid dysregulation as well as insulin resistance, thus, lowering body weight.…”

Section: Reported Biological Activitiesmentioning

confidence: 99%

Phytochemistry and biological properties of glabridin

Simmler¹,

Pauli²,

Chen³

2013

Fitoterapia

223

150

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Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, skin-whitening. While glabridin is one of the most studied licorice flavonoids, a comprehensive literature survey linked to its numerous bioactivities is unavailable. The present review provides a comprehensive description of glabridin as a key chemical and biological marker of G. glabra, by covering both its phytochemical characterization and reported biological activities. Both glabridin and standardized licorice extracts have significant impact on food, dietary supplements (DSs) and cosmetic markets, as evidenced by the amount of available patents and scientific articles since 1976, when glabridin was first described. Nevertheless, a thorough literature survey also reveals that information about the isolation and chemical characterization of this important marker is scattered and less detailed than expected. Accordingly, the first part of this review gathers all analytical and spectroscopic data required for the comprehensive phytochemical characterization of glabridin. The four most frequently described and most relevant bioactivities of glabridin are its anti-inflammatory, anti-atherogenic, estrogenic-like effects, and its capacity to regulate energy metabolism. While all bioactivities reported for glabridin belong to a wide array of targets, its principal biological properties are likely interconnected. To this end, the current state of the literature suggests that the biological activity of glabridin mainly results from its capacity to down-regulate intracellular reactive oxygen species, bind to antioxidant effectors, and act on estrogen receptors, potentially as a plant-based Selective Estrogen Receptor Modulator (phytoSERM).

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“…1), an isoflavan, was firstly isolated from the root of Glycyrrhiza glabra Linne in 1976 [13]. It has been extensively studied and has a variety of pharmacological activities, such as prevention of low density lipoprotein oxidation [14], anti-inflammatory properties [15], neuroprotective effects [16], estrogenic properties [17] and regulation of energy expenditure and metabolism [18]. In addition, it also has some less frequently reported biological activities like antimicrobial activity [19], anti-cancer properties [20] and inhibition of melanogenesis [21].…”

Section: Introductionmentioning

confidence: 99%