Amplification and modelling of bioaffinity detection with terahertz spectroscopy

Mickan, Samuel P.; Menikh, Abdellah; Münch, J.; Abbott, Derek; Zhang, Xicheng

doi:10.1117/12.488143

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…The DTDS output signal depends on the differences between the films on opposite ends of the slide. 348,349 For a typical T-ray spectrometer, the major source of noise is the pump laser, which is very sensitive to slow fluctuations in temperature. These fluctuations can cause larger changes in the detected T-ray signal than the thin film sample itself.…”

Section: Differentialmentioning

confidence: 99%

T-Ray Sensing and Imaging

Mickan

Zhang

2003

Int. J. Hi. Spe. Ele. Syst.

110

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Terahertz (THz) radiation occupies part of the electromagnetic spectrum between the infrared and microwave bands. Until recently, technology at THz frequencies was underdeveloped compared to the rest of the electromagnetic spectrum, leaving a gap between millimeter waves and the far-infrared (FIR). In the past decade, interest in the THz gap has been increased by the development of ultrafast laser-based T-ray systems and their demonstration of diffraction-limited spatial resolution, picosecond temporal resolution, DC-THz spectral bandwidth and signal-to-noise ratios above 10 4 . This chapter reviews the development, the state of the art and the applications of T-ray spectrometers. Continuous-wave (CW) THz-frequency sources and detectors are briefly introduced in comparison to ultrafast pulsed THz systems. An emphasis is placed on experimental applications of T-rays to sensing and imaging, with a view to the continuing advance of technologies and applications in the THz band.

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Section: Differentialmentioning

confidence: 99%

T-Ray Sensing and Imaging

Mickan

Zhang

2003

Int. J. Hi. Spe. Ele. Syst.

110

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“…By taking the reference and sample measurements, required in T-ray spectroscopy, at a higher speed, the fluctuation in laser power between measurements is reduced. Rapid thickness modulation, dubbed T-ray differential time-domain spectroscopy (DTDS), has previously been used on thin films [9][10][11], biosensor slides [5,12], but not on liquids or gases.…”

Section: Introductionmentioning

confidence: 99%

Low noise laser-based T-ray spectroscopy of liquids using double-modulated differential time-domain spectroscopy

Mickan

Shvartsman

Münch

et al. 2004

J. Opt. B: Quantum Semiclass. Opt.

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Liquid transmission studies at terahertz frequencies (0.1-10 THz) are valuable for understanding solvation dynamics of salts, exploring long-range structure in mixtures and probing biomolecules in suspension. Tray (or THz) time-domain spectroscopy, based on terahertz pulse generation from ultrafast lasers, is a sensitive technique for measuring material parameters in this frequency range. This paper proposes and demonstrates a novel technique for increasing the sensitivity and repeatability of liquid studies with Tray time-domain spectroscopy (TDS), reducing relative parameter measurement errors below 0.0001. The proposed technique combines dual-thickness liquid measurement with rapid modulation (double-modulated differential TDS) to reduce the effect of both thickness-measurement errors and Tray noise errors below 0.0001. The possible reduction in error is calculated and a liquid differential TDS (DTDS) prototype is demonstrated, incorporating amplitude and mean detection for near-simultaneous measurement of two Tray waveforms.

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“…By taking the reference and sample measurements, required in T-ray spectroscopy, at a higher speed, the fluctuation in laser power between measurements is reduced. Rapid sample modulation, dubbed T-ray Differential Time-Domain Spectroscopy (DTDS), has previously been used on thin films, [7][8][9] biosensor slides, 10,11 but not on liquid or gas samples.…”

Section: Introductionmentioning

confidence: 99%

Noise reduction in dual-thickness laser-based T-ray material characterization

et al. 2003

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Pulsed THz (T-ray) spectroscopy is an increasingly common tool for studying materials from physics to biology. Liquid transmission T-ray studies are valuable for understanding solvation dynamics of salts, exploring longrange structure in mixtures and probing biomolecules in suspension. In this paper the uncertainty in parameter estimation of liquid samples is shown to be dependent on the thickness change of the sample, and on the noise of the T-ray spectrometer. For many important liquids, such as water, with high THz absorption, we show that measurement uncertainty can be greatly decreased using a dynamically-modulated liquid sample, using differential T-ray time-domain spectroscopy (DTDS). Preliminary experiments with a novel sample holder, based on a loud speaker, support these calculations. Amplitude and mean detection is used to simultaneously measure two waveforms in DTDS, potentially decreasing the noise by 10 2 .

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Amplification and modelling of bioaffinity detection with terahertz spectroscopy

Cited by 3 publications

References 12 publications

T-Ray Sensing and Imaging

T-Ray Sensing and Imaging

Low noise laser-based T-ray spectroscopy of liquids using double-modulated differential time-domain spectroscopy

Noise reduction in dual-thickness laser-based T-ray material characterization

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