Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Noorlag, Rob; Boeve, Koos; Witjes, Max J. H.; Koole, R.; Peeters, Ton; Schuuring, Ed; Willems, Stefan M.

doi:10.1002/hed.24584

Cited by 23 publications

(20 citation statements)

References 33 publications

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“…After elimination of duplicate records, the title and abstract of 133 potentially eligible studies were screened, leading to the selection of 52 studies for evaluation of their full text. Among these articles, 18 met all eligibility criteria for inclusion in the qualitative study and quantitative meta‐analysis …”

Section: Resultsmentioning

confidence: 99%

“…Among these articles, 18 met all eligibility criteria for inclusion in the qualitative study and quantitative meta-analysis. [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Table 1 summarizes the characteristics of the 18 selected studies, which include 1633 patients with HNSCC. The sample size of these studies ranges between 13 and 222 patients.…”

Section: Results Of the Search Of The Literaturementioning

confidence: 99%

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Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2018

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Background To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC). Material and methods We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta‐analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables. Results Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small‐study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas. Conclusions CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Results Of the Search Of The Literaturementioning

confidence: 99%

Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2018

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“…Furthermore, cyclin D1 targeted to the mammary gland was sufficient for the induction of mammary tumorigenesis 10,11 . Clinical studies have shown a correlation between cyclin D1 expression and tumorigenesis and increased cyclin D1 expression is associated with tumor invasion and metastasis [12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

The membrane-associated form of cyclin D1 enhances cellular invasion

et al. 2020

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The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1NL), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1MEM) induced transwell migration and the velocity of cellular migration. The cyclin D1MEM was sufficient to induce G1–S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.

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“…Cyclin D1 overexpression has been related with amplification of the CCND1 gene in several tumours including OSCC [ 22 , 27 , 28 ]. The activation of the pathways involved in cyclin D1 expression appears to be essential in the development of human cancers, including oral cancer [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas

Monteiro

Diniz‐Freitas

Warnakulasuriya

et al. 2018

Analytical Cellular Pathology

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We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in CCND1 gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC). Cyclin A2 expression was observed in 54 (83.1%) tumours, cyclin D1 in 58 (89.2%), cyclin B1 in 39 (60%), and cyclin E in 21 (32.8%). CCND1 region analysis revealed 26 (43.3%) tumours with the presence of numerical aberrations which were correlated with cyclin D1 high expression (Rho = 0.48; p < 0.001). Twenty-nine (45.3%) tumours were classified as high proliferative tumours assessed by Ki-67 protein expression and correlated with tumours with high expression of cyclin A2 (Rho = 0.30; p = 0.016) and cyclin B1 (Rho = 0.37; p = 0.003). In multivariate analysis for an overall five-year survival (OS), we found an adverse independent prognostic value for cyclin A2 high expression (p = 0.031) and for advanced tumour stage (p < 0.001). Our results confirm that several cyclins are commonly expressed in OSCC. CCND1 gene is abnormal in more than one-third of the cases and is frequently associated with cyclin D1 high expression. Moreover, cyclin A2 high expression is an independent indicator of worse OS suggesting that this protein may serve as a reliable biological marker to identify high-risk subgroups with poor prognosis.

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Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Abstract: Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. © 2016 Wiley Periodicals, Inc. Head Neck 39: 326-333, 2017.

Cited by 23 publications

References 33 publications

Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

The membrane-associated form of cyclin D1 enhances cellular invasion

Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas

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