Amplification of graded potentials in horizontal cells of the retina

Byzov, A. L.; Trifonov, Yu. A.; Chailahian, L.M.; Golubtzov, K.W.

doi:10.1016/0042-6989(77)90090-6

Cited by 45 publications

(21 citation statements)

References 18 publications

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“…Although the origin of response enhancement was not directly revealed by the present experiment, there is a possibility that the membrane properties of horizontal cells are involved (in the process). As mentioned above, the voltage-dependence of nonsynaptic membrane is able to enhance the response (BYzov et al, 1977). Furthermore, TACHIBANA (1985) demonstrated that membrane conductance of horizontal cells produced by glutamate, a putative transmitter of cones (see Fig.…”

Section: Discussionmentioning

confidence: 99%

“…MAKSIMOVA et al (1966) were the first to show that the responses of horizontal cells in the perch retina to green light were amplified by red background light. BYzov et al (1977) attributed this response amplification to the resistance increase of a nonsynaptic membrane of horizontal cells. YANG et al (1983) suggested the involvement of the feedback from horizontal cells to cones based on experimental results using two successive light flashes of NEGIsHI (1971) andNEGIsHI (1978) reported that a combination of central spot and annulus illumination resulted in enhanced response.…”

Section: Discussionmentioning

confidence: 99%

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Neural mechanisms of chromatic adaptation in L-type cone horizontal cells of the carp retina.

1989

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When a background light is delivered, the responsiveness of horizontal cells to light stimulus initially lowers but subsequently recovers gradually as shown by the increase in response amplitude to test light. These changes of responsiveness are observed when white or close wavelengths are used for both the background and test lights. However, the response amplitude to blue-green test light was initially enhanced but decreased and reached a steady state after the onset of red background illumination. The mechanism causing such a change of test responses was studied in the luminosity-type cone horizontal cells. The initial response enhancement was accompanied by an increase of the slope of hyperpolarizing phase, while the subsequent decrease of response amplitude was caused by the advancement of the recovery phase. The advancement of the recovery phase was eliminated by y-aminobutyric acid (GABA) or Cot + (50 µM), which blocks GABA-induced currents in cone terminals. Dopamine, which inhibits GABA release from horizontal cells, stimulated the advancement of the recovery phase. The time course of the hyperpolarizing phase was not affected by these agents. The enhancement and the subsequent decrease of test responses were also observed in 6-hydroxydopamine-treated retinae.The results suggest that the GABAergic feedback pathway from horizontal cells to cones advances the recovery phase of response to test light. It appears, therefore, that the feedback modifies the responsiveness of horizontal cells to light stimulus under a red background illumination. The mechanism enhancing response amplitude will be also discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neural mechanisms of chromatic adaptation in L-type cone horizontal cells of the carp retina.

1989

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“…The only essential assumption is a nonlinearity in the HCs. It is, however, highly likely that such nonlinearity exists [81]. Since the retina performs highly specialized transformations on the incoming signals, it would be interesting to analyse how these transformations would affect polarization-guided behaviour.…”

Section: Retinal Model For Polarization Visionmentioning

confidence: 99%

Teleost polarization vision: how it might work and what it might be good for

Kamermans

Hawryshyn

2011

Phil. Trans. R. Soc. B

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In this review, we will discuss the recent literature on fish polarization vision and we will present a model on how the retina processes polarization signals. The model is based on a general retinalprocessing scheme and will be compared with the available electrophysiological data on polarization processing in the retina. The results of this model will help illustrate the functional significance of polarization vision for both feeding behaviour and navigation. First, we examine the linkage between structure and function in polarization vision in general.

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“…Of the three voltage-gated K ÷ currents, only the anomalous rectifier may be activated within the physiological membrane potential range. If this rectifier had been included in the model, the responses of the HCs would have been enhanced (Byzov et al, 1977), possibly resulting in some quantitative differences to very intense stimuli.…”

Section: Voltage-gated Channelsmentioning

confidence: 99%

Color opponency in cone-driven horizontal cells in carp retina. Aspecific pathways between cones and horizontal cells.

Kamermans

Dijk

Spekreijse

1991

The Journal of General Physiology

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A B S T R A C T The spectral and dynamic properties of cone-driven horizontal cells in carp retina were evaluated with silent substitution stimuli and/or saturating background illumination. The aim of this study was to describe the wiring underlying the spectral sensitivity of these cells. We will present electrophysiological data that indicate that all cone-driven horizontal cell types receive input from all spectral cone types, and we will present evidence that all cone-driven horizontal cell types feed back to all spectral cone types. These two findings are the basis for a model for the spectral and dynamic behavior of all cone-driven horizontal cells in carp retina. The model can account for the spectral as well as the dynamic behavior of the horizontal cells. It will be shown that the strength of the feedforward and feedback pathways between a horizontal cell and a particular spectral cone type are roughly proportional. This model is in sharp contrast to the Stell model, where the spectral behavior of the three horizontal cell types is explained by a cascade of feedforward and feedback pathways between cones and horizontal cells. The Stell model accounts for the spectral but not for the dynamic behavior of the horizontal cells. INTRODUCTIONIn carp and goldfish retina three types of cone-driven horizontal cells exist. They are called the mono-, bi-, and triphasic horizontal cells (MHC, BHC, and THC) depending on their spectral sensitivity characteristics (MacNichol and Svaetichin, 1958;Norton et al., 1968). Stell and co-workers (SteU et al., 1975(SteU et al., , 1982Stell, 1976) proposed a cascade model, which relates the spectral response properties of the horizontal cells (HC) to the structure of the ribbon synapse in the cone synaptic terminal. Stell's model is based on a morphological study of Golgi impregnated material from goldfish retina. In that study it was shown VOLUME 97" 1991 that the H 1 cells make central as well as lateral contacts with the synaptic ribbons of the long wavelength sensitive cones (R-cones) and make lateral contacts only with the middle and short wavelength sensitive cones (G-cones, B-cones). The H2 cells, however, make central as well as lateral contacts in the G-cones and make lateral contacts only with the B-cones. Finally, the H3 cells make central as well as lateral contacts only with the B-cones.Assuming that the central HC processes are the forward pathway from the cones to the HCs, that the lateral HC processes are a sign-inverting feedback pathway from HCs to the cones, and that the HI cells correspond to MHCs, H2 cells to BHCs, and H3 cells to THCs, the color coding of the HCs could be explained simply.However, three major problems exist with the Stell model: (a) The dynamics of the responses of all three cone horizontal cell types in carp retina to red light are equal except for latency differences (Spekreijse and Norton, 1970). According to the model of Stell, these responses are generated through different pathways, and hence should show latency as well as dynam...

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Amplification of graded potentials in horizontal cells of the retina

Cited by 45 publications

References 18 publications

Neural mechanisms of chromatic adaptation in L-type cone horizontal cells of the carp retina.

Neural mechanisms of chromatic adaptation in L-type cone horizontal cells of the carp retina.

Teleost polarization vision: how it might work and what it might be good for

Color opponency in cone-driven horizontal cells in carp retina. Aspecific pathways between cones and horizontal cells.

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