Amplification of Nocturnal Melatonin Secretion in Women With Functional Hypothalamic Amenorrhea

Berga, Sarah L.; Mortola, Joseph F.; Yen, S. S. C.

doi:10.1210/jcem-66-1-242

Cited by 187 publications

(75 citation statements)

References 26 publications

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“…When first assessed, this patient's plasma melatonin concentrations were much higher than those reported for hypothalamic amenorrhea, and they declined gradually to the normal range over the course of several years. Interestingly, this patient achieved fertility spontaneously while the melatonin concentrations were still elevated at levels comparable to those reported for hypothalamic amenorrhea [Berga et al, 1988;Brzezinski et al, 19881. To explain fertility despite hypermelatoninemia, the authors of that case report proposed that the important feature of melatonin secretion in relation to the function of the hypothalamic-pituitary-gonadal axis is the change in amplitude or duration of the nocturnal melatonin rise, rather than the absolute values of melatonin concentrations [Puig-Doming0 et al, 19921.…”

Section: Melatonin Secretory Profile In Adultssupporting

confidence: 69%

“…Applying careful methods to characterize the phases of the menstrual cycle and taking frequent blood samples to determine the melatonin secretory profile, Brzezinski et al [ 19881 and Berga and Yen [1990] have demonstrated that the plasma melatonin profile is stable during the various phases of ovarian cycles. Augmented nocturnal melatonin secretion, however, has been reported in hypothalamic amenorrhea [Berga et al, 1988;Brzezinski et al, 19881. Recently Puig-Doming0 et al…”

Section: Melatonin Secretory Profile In Adultsmentioning

confidence: 99%

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Melatonin and human puberty: Current perspectives

Cavallo

1993

Journal of Pineal Research

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Melatonin and human puberty: Current perspectives Cavallo A. Melatonin and human puberty: Current perspectives. J. Pineal Res. 1993: 15: 115-121.Abstract: Many studies of melatonin in human puberty are difficult to interpret in light of methodological considerations such as the use of single blood samples collected either during the day or at night; a small number of observations; the failure to include the temporal characteristics of melatonin secretion; the definition of puberty by the use of broad clinical features without use of hormonal markers of puberty; the lack of control for the actual duration and intensity of light exposure during the days preceding the study; and the cross sectional nature of most studies. The few studies that have examined the plasma melatonin rhythm in humans by multiple blood sampling overnight or over 24 hr suggest that normal pubertal development (as well as normal ovarian function) are not linked to alterations in the plasma melatonin profile. There is, however, some evidence to suggest that disorders of the hypothalamic-pituitary-gonadal axis (delayed puberty, precocious puberty, hypothalamic amenorrhea) may be linked to altered plasma melatonin profile, at least in some cases. These findings, taken together with strong evidence for the role of the pineal gland in the reproductive function of other vertebrate species, render unlikely the inference that the pineal gland has no role in the development and function of the human reproductive axis. Thus, one may speculate that a pineal-puberty relation does exist in humans and that the research techniques applied to date have been inadequate to uncover this relation. Greater knowledge might be gained from studies of melatonin metabolism during growth and pubertal maturation, from longitudinal studies of the melatonin 1 rhythm under rigorously controlled conditions of light exposure, and, perhaps, from the development of research strategies to explore the I human melatonin receptor in vivo.

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Section: Melatonin Secretory Profile In Adultssupporting

confidence: 69%

Section: Melatonin Secretory Profile In Adultsmentioning

confidence: 99%

Melatonin and human puberty: Current perspectives

Cavallo

1993

Journal of Pineal Research

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“…Bu verilerle, pineal melatonin salgılanmasının yeme bozukluğu olan kadınlarda (depresyon faktörü söz konusu değilken) değişme-diği ve bu grupta amenorenin sıklıkla görülmesine melatoninin yol açmadığı vurgulanmıştır. Fonksiyonel hipotalamik amenoreli kadınlar ile normal adet gören foliküler fazın başında olan kadınların 24 saatlik serum melatonin düzeylerinin karşılaştı-rıldığı bir çalışmada hipotalamik amenoreli kadın-larda nokturnal melatonin salgısı normal kadınla-ra göre daha erken başlamış, daha geç bitmiş ve melatonin düzeyi 3 kat fazla çıkmıştır (28). Siklustaki kadınlarda günlük yüksek dozlarda melatoninin kronik uygulaması plazma LH'sını belirgin olarak baskılamış ama 4 aylık tedaviden sonra bile estradiolü inhibe edememiştir.…”

Section: T Ta Ar Ri Ih Hç çE Eunclassified

Melatonin

Akın;ERDOĞAN¹

2003

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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“…Melatonin is thought to be involved in the precocious puberty process (20). Melatonin levels were found to be low in precocious puberty (20,21) and high in women with stress-induced, exercise-induced, or functional hypothalamic hypogonadism (22)(23)(24). It has been postulated that, before puberty, the decline of serum melatonin represents the activating signal for the hypothalamic pulsatile secretion of gonadotropinreleasing hormone, which is necessary for the activation of the gonadotropic axis and, thereafter, the onset of pubertal changes (25).…”

Section: Introductionmentioning

confidence: 99%

Leptin regulation of pubertal maturation in intact and pinealectomized female rats

Kacar¹,

Dinc²,

Yılmaz³

et al. 2013

Turk J Med Sci

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Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone defect, the 2nd experimental group received 1 mL of bisphosphonate as a 10-day fractionated dose, and the control group comprised rats who did not receive any bisphosphonate. At 12 weeks after the injection, new bone tissue was collected and a histological examination was performed. At 12 weeks after the bisphosphonate administration, bone repair processes were found in both the experimental and control groups. The bone continuity in the intervention area was ensured by a continuous layer of bone tissue. Compared with the control, the repair processes were significantly more advanced in the experimental groups, the layer of bone tissue covering the bone defect being thicker and more consolidated and the trabeculae from the Haversian canal being thicker and denser. External and internal consolidation structures were present in animals from all of the groups. Bisphosphonate had a positive influence on bone formation. The stimulatory effect of the bisphosphonate increased with the number of administered doses.

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Amplification of Nocturnal Melatonin Secretion in Women With Functional Hypothalamic Amenorrhea

Cited by 187 publications

References 26 publications

Melatonin and human puberty: Current perspectives

Melatonin and human puberty: Current perspectives

Melatonin

Leptin regulation of pubertal maturation in intact and pinealectomized female rats

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