Amplifications of multiple regions of the HTLV-I genome from DNA of an Italian spastic paraparesis patient but not from DNA of multiple sclerosis patients

French, Deborah; Mammarella, Sandra; Curia, Maria Cristina; Porrini, A.M.; Giampietro, Antonella; Macor, S.; Lombardi, Valter; Agliano, AnnaM.; Manzari, Vittorio; Battista, Pasquale; Frati, Luigi; Gambi, D.; Mariani-Costantini, Renato

doi:10.1016/0022-510x(91)90288-i

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…When initial hypotheses have been refined to test specific viruses as antecedents to putative autoimmune sequelae, results have often disappointed. In Japan, where HTLV-I infection is relatively common, none of 34 multiple sclerosis patients had HTLV-I provirus genome detectable in genomic DNA by polymerase chain reaction (Nishimura et al, 1990;Kaneko et al, 1991); similar results were obtained in studies from Italy (French et al, 1991) and Denmark (Lisby, 1993). Also, none of 23 English multiple sclerosis patients had herpes simplex DNA detectable in their brains by polymerase chain reaction (Nicoll et al, 1992).…”

Section: Viruses and Diseases Of Uncertain Aetiologymentioning

confidence: 83%

1 Viruses, virulence and pathogenicity

Hibbs¹,

Young²

1995

Baillière's Clinical Haematology

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Pathogenicity is a complex process with stringent requirements of both the host cell and the infecting virion. Among these requirements are a port of entry into host cells, a means of replication for the virus, and a means by which infection damages host cells. Damage to the host can result from multiple mechanisms including transformation, suppression of cellular metabolism, apoptosis, autoimmune responses directed against infected or uninfected tissues, or by molecular mimicry. In the attempt to identify new associations between viral infection and disease, investigators should be mindful that variable host factors as well as viral infection may be required for pathogenesis. Efforts to associate specific viral infections with specific diseases may be obscured by final common pathways through which multiple agents damage host cells in similar ways.

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Section: Viruses and Diseases Of Uncertain Aetiologymentioning

confidence: 83%

1 Viruses, virulence and pathogenicity

Hibbs¹,

Young²

1995

Baillière's Clinical Haematology

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Retroviruses and Their Roles in Chronic Inflammatory Diseases and Autoimmunity

et al. 1995

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Isolation from Human Brain of Six Previously Unreported cDNAs Related to the Reverse Transcriptase of Human Endogenous Retroviruses

Lefebvre¹,

Hubert²,

Tekaia³

et al. 1995

AIDS Research and Human Retroviruses

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cDNAs prepared from total RNA extracted from plaques of multiple sclerosis were amplified by the polymerase chain reaction. The 11-bp degenerate primers used were derived from conserved sequences of reverse transcriptase. Amplified cDNAs were fractionated according to size by electrophoresis in polyacrylamide gels under denaturing conditions. cDNAs of the proper size were cloned, grouped according to the sequence of their insert by differential hybridization, and sequenced. Six cDNAs were isolated and found to belong to new members of two groups of human endogenous retroviruses: the group related to ERV9 and that related to HERVK10 and HUMMTV. These sequences were expressed in all human organs tested, including normal white matter of brain. The approach described in this article is a powerful tool with which to isolate new members of the reverse transcriptase gene family.

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Amplifications of multiple regions of the HTLV-I genome from DNA of an Italian spastic paraparesis patient but not from DNA of multiple sclerosis patients

Cited by 5 publications

References 54 publications

1 Viruses, virulence and pathogenicity

1 Viruses, virulence and pathogenicity

Retroviruses and Their Roles in Chronic Inflammatory Diseases and Autoimmunity

Isolation from Human Brain of Six Previously Unreported cDNAs Related to the Reverse Transcriptase of Human Endogenous Retroviruses

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