Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML

Tan, Li; Wei, Xiao-Ping; Zheng, Lianfang; Zeng, Jincai; Liu, Haibo; Yang, Shaojiang; H, Tan

doi:10.1007/s00432-015-2036-9

Cited by 53 publications

(61 citation statements)

References 27 publications

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“…The association between HMGA2 and cancer proliferation has been reported previously . In general, HMGA2 knockdown could inhibit cell growth in several types of cancer, which was similar to our findings in LAC.…”

Section: Discussionsupporting

confidence: 92%

“…Apart from working as a transcription co‐regulator, HMGA2 could also directly regulate gene transcription activation . HMGA2 could function as a regulator of cell proliferation and its expression is increased in many types of human tumor tissues . HMGA2 is also suggested to be involved in EMT regulation in many epithelial carcinomas .…”

Section: Introductionmentioning

confidence: 99%

“…15,16 HMGA2 could function as a regulator of cell proliferation and its expression is increased in many types of human tumor tissues. [17][18][19] HMGA2 is also suggested to be involved in EMT regulation in many epithelial carcinomas. [9][10][11][12]20,21 Intense HMGA2 expression is strongly associated with metastases and poor prognosis in lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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HMGA2 regulates lung cancer proliferation and metastasis

Gao

Dai

et al. 2017

Thoracic Cancer

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BackgroundThis study aimed to explore the effects of HMGA2 on cell proliferation and metastases in lung cancer and its underlying mechanism.Methods HMGA2 expression in lung cancer tissues and its association with overall survival were analyzed based on data from a public database. The roles of HMGA2 were validated via loss‐of‐function and gain‐of‐function experiments in vitro. HMGA2 regulation by microRNA‐195 (miR‐195) was validated by real time‐PCR, Western blotting, and luciferase reporter assays.Results HMGA2 was upregulated and associated with reduced overall survival in patients with lung adenocarcinoma. HMGA2 knockdown suppressed the proliferation and motility of H1299 cells, while HMGA2 ectopic expression in A549 cells increased cell proliferation and migration. HMGA2 affected cell apoptosis through caspase 3/9 and Bcl‐2, and regulated epithelial‐to‐mesenchymal transition by targeting Twist 1. Moreover, miR‐195 was found to directly target the 3′ untranslated region of HMGA2 messenger RNA and suppress its expression in lung cancer.ConclusionThis study demonstrated that HMGA2, regulated by miR‐195, played important roles in proliferation, metastases, and epithelial‐to‐mesenchymal transition in lung cancer. HMGA2 might serve as a biomarker and potential therapeutic target for lung cancer treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HMGA2 regulates lung cancer proliferation and metastasis

Gao

Dai

et al. 2017

Thoracic Cancer

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“…Interestingly, we found that there was a negative correlation between miR-211 and HMGA2 expression in GBM tissues. HMGA2 is able to activate the AKT signaling pathway [27]. AKT could lead to phosphorylation of β-catenin and promotes Wnt pathway signaling.…”

Section: Discussionmentioning

confidence: 99%

Methylation-mediated silencing of microRNA-211 promotes cell growth and epithelial to mesenchymal transition through activation of the AKT/β-catenin pathway in GBM

Miao

Liu

et al. 2017

Oncotarget

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Aberrant expression of miR-211 has frequently been reported in cancer studies; however, its role in glioblastoma multiforme (GBM) has not been examined in detail. We investigated the function and the underlying mechanism of miR-211 in GBM. We revealed that miR-211 was downregulated in GBM tissues and cell lines. Restoration of miR-211 inhibited GBM cell growth and invasion both in vitro and in vivo. The epithelial to mesenchymal transition (EMT) phenotype was reversed when miR-211 expression was restored. HMGA2 was identified as a down-stream target of miR-211. MiR-211 had an inhibitory effect on AKT/β-catenin signaling, which was reversed by HMGA2 overexpression or miR-211 restoration. In addition, miR-211 was transcriptionally repressed by EZH2-induced H3K27 trimethylation and promoter methylation. Overall, our findings revealed miR-211 as a tumor suppressor in GBM and mir-211 may be a potential therapeutic target for GBM patients.

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“…In these cancers, the overexpression of HMGA2 is reported to enhance tumour progression involving the PI3K/Akt/mTOR, HMGA2-TET1-HOX signalling pathways [13,14] and tumour invasiveness by inducing transforming growth factor-β receptor II (TGFβRII) and SMAD transducers in the TGFβ signalling pathway [15,16]. …”

Section: Introductionmentioning

confidence: 99%

Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

et al. 2016

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High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cells (MIO-M1) were optimised. Aptamer induced dose-dependent cytotoxicity in RB cancer cells (0.25-1.5 µM). Increased expression of TGFβ, SMAD4, CDH1, BAX, CASP 3, PARP mRNA and decreased SNAI1, Bcl2 mRNA levels in aptamer-treated RB cells suggests the activation of TGFβ-SMAD4-mediated apoptotic pathway. Synergistic effect with etoposide was observed in aptamer treated RB cells (p value ≤0.05). No significant toxicity was observed in non-neoplastic retinal cells.

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Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML

Abstract: HMGA2 is predominantly amplified and expressed in AML cells, and that aberrant expression of HMGA2 induces AML cell proliferation through the PI3K/Akt/mTOR signaling pathway. Inhibition of HMGA2 expression represents an attractive target for AML therapy.

Cited by 53 publications

References 27 publications

HMGA2 regulates lung cancer proliferation and metastasis

HMGA2 regulates lung cancer proliferation and metastasis

Methylation-mediated silencing of microRNA-211 promotes cell growth and epithelial to mesenchymal transition through activation of the AKT/β-catenin pathway in GBM

Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

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