Amplitude of low-frequency fluctuation (ALFF) alterations in adults with subthreshold depression after physical exercise: A resting-state fMRI study

Huang, Lina; Huang, Guofeng; Ding, Qingguo; Liang, Pei; Hu, Chunhong; Zhang, Hongqiang; Zhan, Linlin; Wang, Qianqian; Cao, Yikang; Zhang, Jun; Shen, Wenbin; Jia, Xize; Xing, Wei

doi:10.1016/j.jad.2021.08.094

Cited by 30 publications

(20 citation statements)

References 63 publications

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“…Moreover, individual analysis revealed that change in peak VO 2 was positively correlated with increases in cognitive composite score and cortical thickness in the right inferior parietal lobule. In support of our findings, the right inferior parietal lobule has shown altered neural activity and functional connectivity after physical exercise training [67,68]. Thus, our results suggest a potential benefit of CRF gain for improving neurocognitive function, regardless of aerobic exercise or stretching.…”

Section: Discussionsupporting

confidence: 88%

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial

et al. 2022

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Background. Current evidence is inconsistent on the benefits of aerobic exercise training for preventing or attenuating age-related cognitive decline in older adults.Objective. To investigate the effects of a 1-year progressive, moderate-to-high intensity aerobic exercise intervention on cognitive function, brain volume, and cortical thickness in sedentary but otherwise healthy older adults.Methods. We randomized 73 older adults to a 1-year aerobic exercise or stretching-and-toning (active control) program. The primary outcome was a cognitive composite score calculated from eight neuropsychological tests encompassing inductive reasoning, long-term and working memory, executive function, and processing speed. Secondary outcomes were brain volume and cortical thickness assessed by MRI, and cardiorespiratory fitness measured by peak oxygen uptake (VO 2 ).Results. One-year aerobic exercise increased peak VO 2 by ∼10% (p < 0.001) while it did not change with stretching (p = 0.241). Cognitive composite scores increased in both the aerobic and stretching groups (p < 0.001 for time effect), although no group difference was observed. Total brain volume (p < 0.001) and mean cortical thickness (p = 0.001) decreased in both groups over time, while the reduction in hippocampal volume was smaller in the stretching group compared with the aerobic group (p = 0.040 for interaction). Across all participants, improvement in peak VO 2 was positively correlated with increases in cognitive composite score (r = 0.282, p = 0.042) and regional cortical thickness at the inferior parietal lobe (p = 0.016). Conclusions.One-year aerobic exercise and stretching interventions improved cognitive performance but did not prevent age-related brain volume loss in sedentary healthy older adults. Cardiorespiratory fitness gain was positively correlated with cognitive performance and regional cortical thickness.

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Section: Discussionsupporting

confidence: 88%

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial

et al. 2022

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“…Resting-state functional magnetic resonance imaging (rs-fMRI) is an oxygen-dependent brain functional imaging method, which can give more accurate structural and functional relationships ( 14 ). As a reliable measure of rs-fMRI techniques, the amplitude of low-frequency fluctuations (ALFF) has been widely applied to assess spontaneous neural activity related to brain metabolism and brain function ( 15 ). Therefore, using rs-fMRI techniques such as ALFF measurement to conduct in-depth research on OSA patients and explore their brain changes has profound significance.…”

Section: Introductionmentioning

confidence: 99%

Aberrant amplitude of low-frequency fluctuations in different frequency bands and changes after one-night positive airway pressure treatment in severe obstructive sleep apnea

et al. 2022

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ObjectiveThis study was aimed to investigate the characteristics of the amplitude of low-frequency fluctuation (ALFF) at specific frequencies in severe obstructive sleep apnea (OSA) patients. A comparison was made between pre-CPAP treatment and one night after continuous positive airway pressure (CPAP) treatment.Methods30 severe OSA patients and 19 healthy controls (HC) were recruited. The ALFF method was used to assess the local features of spontaneous brain activity and calculated at different bands (slow-5 and slow-4). A correlation analysis was performed to evaluate the relationship between the changes of the ALFF and polysomnography data.ResultsCompared with HC, in slow-5 frequency band, OSA patients showed significantly decreased ALFF in the left inferior temporal gyrus, and significantly increased ALFF in the left middle frontal gyrus, left inferior frontal gyrus, triangular part, right superior frontal gyrus, dorsolateral and right middle temporal gyrus. In slow-4 frequency, there was significantly decreased ALFF in the right inferior temporal gyrus, and significantly increased ALFF in the left precuneus, right posterior cingulate gyrus and right median cingulate besides the slow-5 difference band showed. Compared with pre-CPAP, we found that after CPAP treatment, ALFF signals in the left insula in slow-5 and left caudate in slow-4 increased, but the calcarine in slow-4 significantly reduced. Correlation analysis showed that the left angular slow-4 band change was positively correlated with the slow wave sleep change (r = 0.4933, p = 0.0056). The left cerebellum 6 slow-5 band change was positively correlated with the duration of the REM sleep change (r = 0.4563, p = 0.0113), and the left cerebellum 6 slow-4 band change was also positively correlated with the mean blood oxygen change in the REM (r = 0.4591, p = 0.0107) and NREM sleep (r = 0.4492, p = 0.0128).ConclusionWe found that the use of slow-4 was more specific in OSA studies. These results suggested that the severe OSA patients have frequency-related abnormal spontaneous neural activity, which may contribute to a better understanding of the pathological basis of OSA-related diseases and provide a potential therapeutic target for OSA patients.

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“…Students who major in physical education are active, enthusiastic, and energetic. Regular physical exercise can e ectively reduce the risk of depression [22]. Physical exercise and suicide behavior were negatively correlated, and the frequency of physical exercise had the greatest e ect, followed by the duration and intensity of physical exercise [23].…”

Section: Introductionmentioning

confidence: 99%

Investigation on Depression of College Students Majoring in Physical Education and Nonphysical Education: A StudyBased on the Age Region and Gender of 374 Students

Ding

Tang

2022

Evidence-Based Complementary and Alternative Medicine

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In the research on the relationship between depression and college students’ major, there are some differences in the degree of depression between sports major and nonsports major students. Based on these results, we assume that there is the possibility of emotional differences between professional and nonprofessional sports. A total of 374 samples of students majoring in physical education and nonphysical education at the same university were analyzed by using the methods of literature review and data analysis. A total of 188 subjects, including 121 males and 253 females (186 majoring in sports and nonsports), were asked to fill in the SDS (Self-Rating Depression Scale). SDS is widely used in rough screening, emotional state evaluation, investigation, and scientific research of outpatients in clinical psychology departments. The research obtained the difference in depression degree in the whole sample and further compared the depression degree of students of different ages and native places. Statistical analysis was performed on all data using SPSS 23.0 software. Basic data description, paired chi-square analysis, and covariance analysis were used. The results show that in this sample, the maximum value (minimum/maximum value) of one item of the total depression score of nonphysical education students exceeds the average value by 3 standard deviations, and this shows that the general level of depression scores of non-PE majors is high; most non-PE majors are in mild depression, which is equal to the number of PE majors who are in a normal mood; and nonsports majors in cities are more likely to have mild depression.

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Amplitude of low-frequency fluctuation (ALFF) alterations in adults with subthreshold depression after physical exercise: A resting-state fMRI study

Cited by 30 publications

References 63 publications

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial

Aberrant amplitude of low-frequency fluctuations in different frequency bands and changes after one-night positive airway pressure treatment in severe obstructive sleep apnea

Investigation on Depression of College Students Majoring in Physical Education and Nonphysical Education: A StudyBased on the Age Region and Gender of 374 Students

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